{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T09:12:27Z","timestamp":1769850747795,"version":"3.49.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":1935,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Universit\u00e9 de Montr\u00e9al Beaulieu-Saucier Chair in Pharmacogenomics"},{"DOI":"10.13039\/501100012651","name":"Montreal Heart Institute Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012651","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012651","name":"Fondation Institut de Cardiologie de Montr\u00e9al","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012651","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Few investigations have been conducted to identify genetic determinants of common, polygenetic forms of heart failure (HF), and only a limited number of these genetic associations have been validated by multiple groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We performed a case\u2013control study to further investigate the potential impact of 14 previously reported candidate genes on the risk of HF and specific HF sub-types. We also performed an exploratory genome-wide study. We included 799 patients with HF and 1529 controls. After adjusting for age, sex, and genetic ancestry, we found that the C allele of rs2234962 in BAG3 was associated with a decreased risk of idiopathic dilated cardiomyopathy (odds ratio 0.42, 95% confidence interval 0.25\u20130.68, P = 0.0005), consistent with a previous report. No association for the other primary variants or exploratory genome-wide study was found.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings provide independent replication for the association between a common coding variant (rs2234962) in BAG3 and the risk of idiopathic dilated cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12934","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T06:18:51Z","timestamp":1598941131000},"page":"4384-4389","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A Genetic Association Study of Heart Failure: More Evidence for the Role of BAG3 in Idiopathic Dilated Cardiomyopathy"],"prefix":"10.1093","volume":"7","author":[{"given":"Simon","family":"de Denus","sequence":"first","affiliation":[{"name":"Montreal Heart Institute , 5000 B\u00e9langer, Montreal, QC, H1T 1C8 ,","place":["Canada"]},{"name":"Faculty of Pharmacy, Universit\u00e9 de Montr\u00e9al , Montreal, QC ,","place":["Canada"]},{"name":"Universit\u00e9 de Montreal Beaulieu-Saucier Pharmacogenomics Center , Montreal, QC ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fannie","family":"Mottet","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute , 5000 B\u00e9langer, Montreal, QC, H1T 1C8 ,","place":["Canada"]},{"name":"Faculty of Pharmacy, Universit\u00e9 de Montr\u00e9al , Montreal, QC ,","place":["Canada"]},{"name":"Faculty of Medicine, Universit\u00e9 de Montr\u00e9al , Montreal, QC ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Korol","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute , 5000 B\u00e9langer, Montreal, QC, H1T 1C8 ,","place":["Canada"]},{"name":"Faculty of Pharmacy, Universit\u00e9 de Montr\u00e9al , Montreal, QC ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yassamin","family":"Feroz Zada","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute , 5000 B\u00e9langer, Montreal, QC, H1T 1C8 ,","place":["Canada"]},{"name":"Universit\u00e9 de Montreal Beaulieu-Saucier Pharmacogenomics Center , Montreal, QC ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"Provost","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute , 5000 B\u00e9langer, Montreal, QC, H1T 1C8 ,","place":["Canada"]},{"name":"Universit\u00e9 de Montreal Beaulieu-Saucier Pharmacogenomics Center , Montreal, QC ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Mongrain","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute , 5000 B\u00e9langer, Montreal, QC, H1T 1C8 ,","place":["Canada"]},{"name":"Universit\u00e9 de Montreal Beaulieu-Saucier Pharmacogenomics Center , Montreal, QC ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e9raldine","family":"Asselin","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute , 5000 B\u00e9langer, Montreal, QC, H1T 1C8 ,","place":["Canada"]},{"name":"Universit\u00e9 de Montreal Beaulieu-Saucier Pharmacogenomics Center , Montreal, QC ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Essa\u00efd","family":"Oussa\u00efd","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Universit\u00e9 de Montr\u00e9al , Montreal, QC ,","place":["Canada"]},{"name":"Universit\u00e9 de Montreal Beaulieu-Saucier Pharmacogenomics Center , Montreal, QC ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Busseuil","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute , 5000 B\u00e9langer, Montreal, QC, H1T 1C8 ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Lettre","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute , 5000 B\u00e9langer, Montreal, QC, H1T 1C8 ,","place":["Canada"]},{"name":"Faculty of Medicine, Universit\u00e9 de Montr\u00e9al , Montreal, QC ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Rioux","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute , 5000 B\u00e9langer, Montreal, QC, H1T 1C8 ,","place":["Canada"]},{"name":"Faculty of Medicine, Universit\u00e9 de Montr\u00e9al , Montreal, QC ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Normand","family":"Racine","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute , 5000 B\u00e9langer, Montreal, QC, H1T 1C8 ,","place":["Canada"]},{"name":"Faculty of Medicine, Universit\u00e9 de Montr\u00e9al , Montreal, QC ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen","family":"O'Meara","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute , 5000 B\u00e9langer, Montreal, QC, H1T 1C8 ,","place":["Canada"]},{"name":"Faculty of Medicine, Universit\u00e9 de Montr\u00e9al , Montreal, QC ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"White","sequence":"additional","affiliation":[{"name":"Montreal Heart Institute , 5000 B\u00e9langer, Montreal, QC, H1T 1C8 ,","place":["Canada"]},{"name":"Faculty of Medicine, Universit\u00e9 de Montr\u00e9al , Montreal, QC 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