{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T22:31:40Z","timestamp":1769121100188,"version":"3.49.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":1954,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T00:00:00Z","timestamp":1597276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We sought to evaluate the effectiveness of cardiac resynchronization therapy (CRT) in far-advanced heart failure (FA-HF) patients with New York Heart Association (NYHA) class-IV status and dependency on intravenous drugs (IVDs) and\/or invasive supportive treatments (ISTs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Among 305 patients who underwent CRT implantation between October 2005 to December 2019, we identified 17 FA-HF patients with NYHA class-IV status and dependency on IVDs (inotropes, diuretics, vasopressors, or vasodilators) and\/or ISTs (extracorporeal membranous oxygenator or continuous renal replacement therapy). All patients (median age = 68.7 years, non-ischaemic cardiomyopathy = 15) remained dependent on several IVDs (2.2 \u00b1 1.3 per patient) and\/or ISTs for 11.3 \u00b1 7.8 days due to multiple tapering failure (4.3 \u00b1 3.2 per patient) before CRT implantation. However, 14 (82%) patients were successfully weaned from IVDs\/ISTs within 5.2 \u00b1 5.3 days following CRT, and 12 (71%) stayed alive for more than 1 year free of ventricular assist device or heart transplantation with symptom improvement (\u22651 NYHA class) and a reduced annual HF hospitalization rate (P = 0.002). Considerable improvements in ventricular systolic function (P = 0.004) and volumetric reverse remodelling (P = 0.007) were noticed during the long-term follow-up period (35 \u00b1 15 months post-CRT). The ventricular assist device\/heart transplantation\/death-free survival rate post-CRT was 71% and 65% at 1 and 3 years, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cardiac resynchronization therapy implantation may be a feasible treatment that can offer short-term and long-term clinical benefits for NYHA class-IV FA-HF patients who are dependent on IVDs\/ISTs. When considering treatment options, CRT should not be prematurely excluded solely based on a patient's dependency on IVDs\/ISTs without first attempting to identify favourable CRT response factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12940","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T09:49:27Z","timestamp":1597312167000},"page":"3109-3118","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cardiac Resynchronization Therapy in New York Heart Association Class-IV Patients Dependent on Intravenous Drugs or Invasive Supportive Treatments"],"prefix":"10.1093","volume":"7","author":[{"given":"Seong Soo","family":"Lee","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine , 81, Irwon-ro, Gangnam-gu, Seoul, 06351 ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee-Jin","family":"Kwon","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine , 81, Irwon-ro, Gangnam-gu, Seoul, 06351 ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoung-Min","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine , 81, Irwon-ro, Gangnam-gu, Seoul, 06351 ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Keun","family":"On","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine , 81, Irwon-ro, Gangnam-gu, Seoul, 06351 ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"June Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine , 81, Irwon-ro, Gangnam-gu, Seoul, 06351 ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Jung","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine , 81, Irwon-ro, Gangnam-gu, Seoul, 06351 ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,8,13]]},"reference":[{"key":"2026012114051700500_ehf212940-bib-0001","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1056\/NEJMoa032423","article-title":"Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure","volume":"350","author":"Bristow","year":"2004","journal-title":"N Engl J Med"},{"key":"2026012114051700500_ehf212940-bib-0002","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1093\/eurheartj\/ehl099","article-title":"Longer-term effects of cardiac resynchronization therapy on mortality in heart failure [the CArdiac REsynchronization-Heart Failure (CARE-HF) trial extension phase]","volume":"27","author":"Cleland","year":"2006","journal-title":"Eur Heart J"},{"key":"2026012114051700500_ehf212940-bib-0003","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.1093\/eurheartj\/eht290","article-title":"An individual patient meta-analysis of five randomized trials assessing the effects of cardiac resynchronization therapy on morbidity and mortality in patients with symptomatic heart failure","volume":"34","author":"Cleland","year":"2013","journal-title":"Eur Heart J"},{"key":"2026012114051700500_ehf212940-bib-0004","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1093\/eurheartj\/eht150","article-title":"ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: the Task Force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). 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