{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T04:41:44Z","timestamp":1774154504096,"version":"3.50.1"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":1926,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to assess the value of the hepatocyte growth factor (HGF) as an independent predictor of a Fontan circulation failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This retrospective case\u2013control study included 34 consecutive patients (19 men and 15 women) who underwent a post-operative cardiac catheterization after a Fontan operation at the Saitama Medical University International Medical Center between April 2017 and December 2019. We divided the patients into two groups according to the HGF level: HGF &amp;lt; 0.4 ng\/mL (n = 20, normal HGF group) and HGF \u2265 0.4 ng\/mL (n = 14, elevated HGF group). The age at the time of the cardiac catheterization was 59.3 \u00b1 7.9 months. The range of the duration between the Fontan operation and the cardiac catheterization was 37.5 \u00b1 7.9 months. The age (P = 0.417), gender (P = 0.08), morphology of the functional ventricle (P = 0.99), presence or closure of the Fontan fenestration (P = 0.704), and rate of medication use (angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers) (P = 0.99) were equivalent between the two groups. Laboratory parameters including the brain natriuretic peptide level (P = 0.085), serum creatinine level (P = 0.27), and aspartate aminotransferase level (P = 0.235) were similar between the two groups. The elevated HGF group had a higher C-reactive protein level than the normal HGF group (0.42 \u00b1 0.14 and 0.05 \u00b1 0.01 mg\/dL, P = 0.005). The elevated HGF group had a higher central venous pressure (CVP) level than the normal HGF group (13.4 \u00b1 0.7 and 9.7 \u00b1 0.4 mmHg, P &amp;lt; 0.0001), and the HGF was positively correlated with the CVP (P = 0.0004, r2 = 0.33). The SvO2 level was significantly lower in the elevated HGF group than in the normal HGF group (61.9 \u00b1 2.3% and 75.0 \u00b1 1.2%, P &amp;lt; 0.0001), and the HGF was negatively correlated with the SvO2 (P &amp;lt; 0.0001, r2 = 0.65). Of the 34 patients, six underwent catheter interventions. Patients who underwent catheter interventions had a higher HGF level than those who did not (0.44 \u00b1 0.03 and 0.37 \u00b1 0.01 ng\/mL, P = 0.032). The receiver operating characteristic curve created for the discrimination of a catheter intervention revealed that an HGF value of &amp;gt;0.405 ng\/mL could detect the need for a catheter intervention with 75.0% sensitivity and 83.3% specificity. A multivariable regression analysis showed that an elevated HGF was an independent predictor of an elevated CVP (\u03b2-coefficient 21.2, SE 5.5, P = 0.0005) and decreased SvO2 (\u03b2-coefficient \u221292.9, SE 12.4, P &amp;lt; 0.0001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The HGF is an independent predictor of a failure of a Fontan circulation. The HGF is an indicator for an additional catheter intervention after a Fontan operation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12943","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T12:39:08Z","timestamp":1601037548000},"page":"3738-3744","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hepatocyte Growth Factor Predicts Failure of Fontan Circulation"],"prefix":"10.1093","volume":"7","author":[{"given":"Takuro","family":"Kojima","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology, Saitama Medical University International Medical Center , 1397-1 Yamane, Hidaka, Saitama, 350-1298 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moe","family":"Taki","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Saitama Medical University International Medical Center , 1397-1 Yamane, Hidaka, Saitama, 350-1298 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Toda","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Saitama Medical University International Medical Center , 1397-1 Yamane, Hidaka, Saitama, 350-1298 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shota","family":"Muraji","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Saitama Medical University International Medical Center , 1397-1 Yamane, Hidaka, Saitama, 350-1298 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeki","family":"Yoshiba","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Saitama Medical University International Medical Center , 1397-1 Yamane, Hidaka, Saitama, 350-1298 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Kobayshi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Saitama Medical University International Medical Center , 1397-1 Yamane, Hidaka, Saitama, 350-1298 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7094-6772","authenticated-orcid":false,"given":"Naokata","family":"Sumitomo","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Saitama Medical University International Medical Center , 1397-1 Yamane, Hidaka, Saitama, 350-1298 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,9,10]]},"reference":[{"key":"2026012114075482300_ehf212943-bib-0001","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1136\/thx.26.3.240","article-title":"Surgical repair of tricuspid 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