{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T19:04:53Z","timestamp":1769108693716,"version":"3.49.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":1925,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T00:00:00Z","timestamp":1599782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research","doi-asserted-by":"publisher","award":["BMBF 01EO1503"],"award-info":[{"award-number":["BMBF 01EO1503"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"name":"German Federal Ministry of Education and Research"},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["BMBF 01EO1503"],"award-info":[{"award-number":["BMBF 01EO1503"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Several approaches for transcatheter mitral valve repair for functional mitral valve regurgitation are established. Interventional direct annuloplasty is a novel trans-venous, trans-septal approach. While feasibility was proven recently, knowledge on its influence on cardiac dimensions, pressures, biomarkers, and clinical outcomes is sparse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Patients consecutively treated with direct annuloplasty-only procedures between December 2015 and April 2018 were included in this monocentric analysis. Echocardiographic measurements, biomarker levels, clinical status [New York Heart Association (NYHA) class and 6 min walk test] were assessed at baseline, at discharge, and at a 30 day follow-up. Overall, 18 patients (in mean 77.0 \u00b1 7.4 years, 44.4% women) with initially all high-grade mitral valve regurgitation (MR) were included in this study. Procedural success rate was high (94.4%) without severe complications. Direct annuloplasty resulted in MR-reduction (post-procedural-MR mild or no\/trace: 72.2%) and the proportion of patients with severe dyspnoea (NYHA III\/IV) was reduced (88.9% vs. 50%, P = 0.008). Clinical results were associated with a relevant diminution of left atrial volumes (\u221216.5%, P &amp;lt; 0.001) and cardiac pressures [left atrial pressure (\u221232.3%, P = 0.019) and systolic pulmonary arterial pressure (PAP, \u221215.8%, P = 0.025)]. Patients with lower baseline levels of PAP (P = 0.022) as well as elevated highly sensitive troponin (P = 0.034) were more likely to archive clinical benefit (improvement in NYHA class \u22651 grade) after 1 month, which could not be correlated with the grade of MR-reduction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Transcatheter mitral valve repair by direct annuloplasty results in a relevant reduction of intracardiac pressures, left atrial volumes, dyspnoea, and MR. Lower PAP and higher troponin values at baseline could be associated to dyspnoea reduction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.12957","type":"journal-article","created":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T07:54:23Z","timestamp":1601193263000},"page":"3336-3344","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association of Transcatheter Direct Mitral Annuloplasty with Acute Anatomic, Haemodynamic, and Clinical Outcomes in Severe Mitral Valve Regurgitation"],"prefix":"10.1093","volume":"7","author":[{"given":"Martin","family":"Geyer","sequence":"first","affiliation":[{"name":"Center for Cardiology, Cardiology I, University Medical Center Mainz (Johannes Gutenberg-University Mainz) , Langenbeckstr. 1, Mainz, 55131 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karsten","family":"Keller","sequence":"additional","affiliation":[{"name":"Center for Cardiology, Cardiology I, University Medical Center Mainz (Johannes Gutenberg-University Mainz) , Langenbeckstr. 1, Mainz, 55131 ,","place":["Germany"]},{"name":"Center for Thrombosis and Hemostasis, University Medical Center Mainz (Johannes Gutenberg-University Mainz) , Mainz ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efthymios","family":"Sotiriou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Klinikum Mutterhaus Mitte , Trier ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander R.","family":"Tamm","sequence":"additional","affiliation":[{"name":"Center for Cardiology, Cardiology I, University Medical Center Mainz (Johannes Gutenberg-University Mainz) , Langenbeckstr. 1, Mainz, 55131 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias F.","family":"Ruf","sequence":"additional","affiliation":[{"name":"Center for Cardiology, Cardiology I, University Medical Center Mainz (Johannes Gutenberg-University Mainz) , Langenbeckstr. 1, Mainz, 55131 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Kreidel","sequence":"additional","affiliation":[{"name":"Center for Cardiology, Cardiology I, University Medical Center Mainz (Johannes Gutenberg-University Mainz) , Langenbeckstr. 1, Mainz, 55131 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andres","family":"Beiras-Fernandez","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery, University Medical Center Mainz (Johannes Gutenberg-University Mainz) , Mainz 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Mainz (Johannes Gutenberg-University Mainz) , Langenbeckstr. 1, Mainz, 55131 ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Rhine Main , Mainz ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph Stephan","family":"von Bardeleben","sequence":"additional","affiliation":[{"name":"Center for Cardiology, Cardiology I, University Medical Center Mainz (Johannes Gutenberg-University Mainz) , Langenbeckstr. 1, Mainz, 55131 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,9,11]]},"reference":[{"key":"2026012114073779200_ehf212957-bib-0001","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S0002-9149(00)01362-X","article-title":"Prevalence and correlates of mitral regurgitation in a population-based sample (the Strong Heart Study)","volume":"87","author":"Jones","year":"2001","journal-title":"Am J 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