{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:38:08Z","timestamp":1790836688016,"version":"4.1.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":1865,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T00:00:00Z","timestamp":1605052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Dilated cardiomyopathy (DCM) is a complex disease where genetics interplay with extrinsic factors. This study aims to compare the phenotype, management, and outcome of familial DCM (FDCM) and non-familial (sporadic) DCM (SDCM) across Europe.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Patients with DCM that were enrolled in the prospective ESC EORP Cardiomyopathy &amp; Myocarditis Registry were included. Baseline characteristics, genetic testing, genetic yield, and outcome were analysed comparing FDCM and SDCM; 1260 adult patients were studied (238 FDCM, 707 SDCM, and 315 not disclosed). Patients with FDCM were younger (P &amp;lt; 0.01), had less severe disease phenotype at presentation (P &amp;lt; 0.02), more favourable baseline cardiovascular risk profiles (P \u2264 0.007), and less medication use (P \u2264 0.042). Outcome at 1 year was similar and predicted by NYHA class (HR 0.45; 95% CI [0.25\u20130.81]) and LVEF per % decrease (HR 1.05; 95% CI [1.02\u20131.08]. Throughout Europe, patients with FDCM received more genetic testing (47% vs. 8%, P &amp;lt; 0.01) and had higher genetic yield (55% vs. 22%, P &amp;lt; 0.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We observed that FDCM and SDCM have significant differences at baseline but similar short-term prognosis. Whether modification of associated cardiovascular risk factors provide opportunities for treatment remains to be investigated. Our results also show a prevalent role of genetics in FDCM and a non-marginal yield in SDCM although genetic testing is largely neglected in SDCM. Limited genetic testing and heterogeneity in panels provides a scaffold for improvement of guideline adherence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13100","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T02:42:40Z","timestamp":1605148960000},"page":"95-105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Differences Between Familial and Sporadic Dilated Cardiomyopathy: ESC EORP Cardiomyopathy &amp; Myocarditis Registry"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1692-8669","authenticated-orcid":false,"given":"Folkert W.","family":"Asselbergs","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Medical Centre Utrecht, University of Utrecht , Heidelberglaan 100, Utrecht, 3584CX ,","place":["The Netherlands"]},{"name":"Institute of Cardiovascular Science and Institute of Health Informatics, Faculty of Population Health Sciences, University College London , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5557-9342","authenticated-orcid":false,"given":"Arjan","family":"Sammani","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Centre Utrecht, University of Utrecht , Heidelberglaan 100, Utrecht, 3584CX ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3383-3984","authenticated-orcid":false,"given":"Perry","family":"Elliott","sequence":"additional","affiliation":[{"name":"Barts Heart Centre, St Bartholomew's Hospital, University College London and Inherited Cardiac Diseases Unit , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5818-1754","authenticated-orcid":false,"given":"Juan R.","family":"Gimeno","sequence":"additional","affiliation":[{"name":"Cardiac Department, Hospital Universitario Virgen de la Arrixaca , Murcia ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Tavazzi","sequence":"additional","affiliation":[{"name":"GVM Care & Research, Maria Cecilia Hospital , Cotignola ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Tendera","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Structural Heart Diseases, School of Medicine in Katowice, Medical University of Silesia , Katowice ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0014-9927","authenticated-orcid":false,"given":"Juan Pablo","family":"Kaski","sequence":"additional","affiliation":[{"name":"Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital, UK and University College London Institute of Cardiovascular Science , London ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2764-6779","authenticated-orcid":false,"given":"Aldo P.","family":"Maggioni","sequence":"additional","affiliation":[{"name":"GVM Care & Research, Maria Cecilia Hospital , Cotignola ,","place":["Italy"]},{"name":"EUR Observational Research Programme, European Society of Cardiology , Sophia-Antipolis ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6979-3411","authenticated-orcid":false,"given":"Pawel P.","family":"Rubis","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Vascular Diseases, Jagiellonian University Medical College, John Paul II Hospital , Krakow ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruxandra","family":"Jurcut","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Emergency Institute of Cardiovascular Diseases C.C. Iliescu , Bucharest ,","place":["Romania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9640-9040","authenticated-orcid":false,"given":"Tiina","family":"Heli\u00f6","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Helsinki University Central Hospital Meilahti , Helsinki ,","place":["Finland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Cal\u00f2","sequence":"additional","affiliation":[{"name":"U.O. 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