{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T13:30:58Z","timestamp":1769088658005,"version":"3.49.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":1810,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005646","name":"Actelion Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005646","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Avtal om L\u00e4karutbildning och Forskning"},{"DOI":"10.13039\/501100018846","name":"Swedish Society of Pulmonary Hypertension","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018846","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005646","name":"Actelion Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Right ventricular dysfunction may arise because of pulmonary arterial hypertension (PAH). Development of new diagnostic methods able to identify PAH and allow for earlier treatment initiation, before the development of vascular remodelling and manifest right heart failure (HF), could potentially improve prognosis. Proteoglycans and inflammatory proteins are involved in vascular remodelling. We aimed to investigate their potential as biomarkers to differentiate PAH in a dyspnoeic population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Plasma from 152 patients with PAH (n = 48), chronic thrombo-embolic pulmonary hypertension (n = 20), pulmonary hypertension due to HF with reduced (n = 36) or preserved (n = 33) ejection fraction, and HF without pulmonary hypertension (n = 15) and 20 healthy controls were analysed with proximity extension assays. Haemodynamics were assessed in the patients with right heart catheterization. Plasma prolargin levels in PAH were lower compared with all the other studied disease groups (P &amp;lt; 0.001) but higher than the controls' levels (P = 0.003). Receiver operating characteristic curve of prolargin as a PAH-differentiating marker in a pooled population, encompassing all the other studied disease groups, had a sensitivity of 74% and a specificity of 83.3% (area under the curve = 0.84, P &amp;lt; 0.001). Prolargin correlated with the mean right atrial pressure (rs = 0.65, P &amp;lt; 0.001), N-terminal pro-brain natriuretic peptide (rs = 0.64, P &amp;lt; 0.001), cardiac index (rs = \u22120.31, P = 0.029), stroke volume index (rs = \u22120.41, P = 0.004), right ventricular stroke work index (rs = \u22120.31, P = 0.032), six-minute walking distance (rs = \u22120.41, P = 0.005), and mixed venous blood oxygen saturation (rs = \u22120.42, P = 0.003).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Plasma prolargin levels differentiate PAH patients from controls and the other investigated dyspnoea groups including HF. Its potential in PAH differentiation may be enhanced by inclusion in a multi-marker panel. Larger studies are needed to evaluate its discriminative ability of PAH in relation to other dyspnoea aetiologies and its potential role in PAH risk stratification and pathobiology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13184","type":"journal-article","created":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T21:15:01Z","timestamp":1609967701000},"page":"1230-1243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Plasma Proteoglycan Prolargin in Diagnosis and Differentiation of Pulmonary Arterial Hypertension"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5315-7819","authenticated-orcid":false,"given":"Mattias","family":"Arvidsson","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Lund, Cardiology, Faculty of Medicine, Lund University , Lund ,","place":["Sweden"]},{"name":"The Hemodynamic Lab, The Section for Heart Failure and Valvular Disease, VO Heart and Lung Medicine, Sk\u00e5ne University Hospital , Lund ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6005-5300","authenticated-orcid":false,"given":"Abdulla","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Cardiology, Faculty of Medicine, Lund University , Lund ,","place":["Sweden"]},{"name":"The Hemodynamic Lab, The Section for Heart Failure and Valvular Disease, VO Heart and Lung Medicine, Sk\u00e5ne University Hospital , Lund ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9956-7060","authenticated-orcid":false,"given":"Habib","family":"Bouzina","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Cardiology, Faculty of Medicine, Lund University , Lund ,","place":["Sweden"]},{"name":"The Hemodynamic Lab, The Section for Heart Failure and Valvular Disease, VO Heart and Lung Medicine, Sk\u00e5ne University Hospital , Lund ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4919-2771","authenticated-orcid":false,"given":"G\u00f6ran","family":"R\u00e5degran","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Cardiology, Faculty of Medicine, Lund University , Lund ,","place":["Sweden"]},{"name":"The Hemodynamic Lab, The Section for Heart Failure and Valvular Disease, VO Heart and Lung Medicine, Sk\u00e5ne University Hospital , Lund ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,1,5]]},"reference":[{"key":"2026012115080536300_ehf213184-bib-0001","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1016\/j.jacc.2004.02.029","article-title":"Cellular and molecular pathobiology of pulmonary arterial hypertension","volume":"43","author":"Humbert","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"2026012115080536300_ehf213184-bib-0002","first-page":"e578","article-title":"Evaluation and management of right-sided heart failure: a scientific statement from the American Heart Association","volume":"137","author":"Konstam Marvin","year":"2018","journal-title":"Circulation"},{"key":"2026012115080536300_ehf213184-bib-0003","doi-asserted-by":"crossref","first-page":"343","DOI":"10.7326\/0003-4819-115-5-343","article-title":"Survival in patients with primary pulmonary hypertension: results from a national prospective registry","volume":"115","author":"D'Alonzo","year":"1991","journal-title":"Ann Intern Med"},{"key":"2026012115080536300_ehf213184-bib-0004","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/eurheartj\/ehv317","article-title":"2015 ESC\/ERS guidelines for the diagnosis and treatment of pulmonary hypertension: the Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT)","volume":"37","author":"Gali\u00e8","year":"2016","journal-title":"Eur Heart J"},{"key":"2026012115080536300_ehf213184-bib-0005","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1183\/09059180.00005112","article-title":"Early detection and management of pulmonary arterial hypertension","volume":"21","author":"Humbert","year":"2012","journal-title":"Eur Respir Rev"},{"key":"2026012115080536300_ehf213184-bib-0006","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01904-2018","article-title":"Diagnosis of pulmonary hypertension","volume":"53","author":"Frost","year":"2019","journal-title":"Eur Respir J"},{"key":"2026012115080536300_ehf213184-bib-0007","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1016\/j.bbadis.2014.07.008","article-title":"Vascular wall extracellular matrix proteins and vascular diseases","volume":"1842","author":"Xu","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"2026012115080536300_ehf213184-bib-0008","first-page":"121","article-title":"Active collagen synthesis by pulmonary arteries in human primary pulmonary hypertension","volume":"143","author":"Botney","year":"1993","journal-title":"Am J Pathol"},{"key":"2026012115080536300_ehf213184-bib-0009","doi-asserted-by":"crossref","first-page":"H1322","DOI":"10.1152\/ajpheart.00136.2018","article-title":"Role of extracellular matrix in the pathogenesis of pulmonary arterial hypertension","volume":"315","author":"Thenappan","year":"2018","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026012115080536300_ehf213184-bib-0010","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01887-2018","article-title":"Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives","volume":"53","author":"Humbert","year":"2019","journal-title":"Eur Respir J"},{"key":"2026012115080536300_ehf213184-bib-0011","doi-asserted-by":"crossref","DOI":"10.1177\/2045894019895414","article-title":"Matrix metalloproteinase 7 in diagnosis and differentiation of pulmonary arterial hypertension","volume":"9","author":"Arvidsson","year":"2019","journal-title":"Pulm Circ"},{"key":"2026012115080536300_ehf213184-bib-0012","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nrm3902","article-title":"Extracellular matrix assembly: a multiscale deconstruction","volume":"15","author":"Mouw","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026012115080536300_ehf213184-bib-0013","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.matbio.2014.05.001","article-title":"Proteoglycans, key regulators of cell\u2013matrix dynamics","volume":"35","author":"Schaefer","year":"2014","journal-title":"Matrix Biol"},{"key":"2026012115080536300_ehf213184-bib-0014","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.matbio.2018.01.001","article-title":"Sweet, yet underappreciated: proteoglycans and extracellular matrix remodeling in heart disease","volume":"75-76","author":"Christensen","year":"2019","journal-title":"Matrix Biol"},{"key":"2026012115080536300_ehf213184-bib-0015","doi-asserted-by":"crossref","first-page":"L1327","DOI":"10.1152\/ajplung.2001.280.6.L1327","article-title":"Proteoglycans decorin and biglycan differentially modulate TGF-\u03b2-mediated fibrotic responses in the lung","volume":"280","author":"Kolb","year":"2001","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2026012115080536300_ehf213184-bib-0016","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1039\/C3IB40199E","article-title":"Shear-induced endothelial NOS activation and remodeling via heparan sulfate, glypican-1, and syndecan-1","volume":"6","author":"Ebong","year":"2014","journal-title":"Integr Biol"},{"key":"2026012115080536300_ehf213184-bib-0017","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/jlb.67.2.149","article-title":"Extracellular matrix moieties, cytokines, and enzymes: dynamic effects on immune cell behavior and inflammation","volume":"67","author":"Vaday","year":"2000","journal-title":"J Leukoc Biol"},{"key":"2026012115080536300_ehf213184-bib-0018","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095192","article-title":"Homogenous 96-plex PEA immunoassay exhibiting high sensitivity, specificity, and excellent scalability","volume":"9","author":"Assarsson","year":"2014","journal-title":"PLoS ONE"},{"key":"2026012115080536300_ehf213184-bib-0019","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc B Methodol"},{"key":"2026012115080536300_ehf213184-bib-0020","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1214\/aos\/1013699998","article-title":"The control of the false discovery rate in multiple testing under dependency","volume":"29","author":"Benjamini","year":"2001","journal-title":"Ann Stat"},{"key":"2026012115080536300_ehf213184-bib-0021","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/j.2040-4603.2015.tb00624.x","article-title":"Extracellular matrix communication and turnover in cardiac physiology and pathology","volume":"5","author":"Takawale","year":"2015","journal-title":"Compr Physiol"},{"key":"2026012115080536300_ehf213184-bib-0022","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/joim.12400","article-title":"The small leucine-rich repeat proteoglycans in tissue repair and atherosclerosis","volume":"278","author":"Hultgardh-Nilsson","year":"2015","journal-title":"J Intern Med"},{"key":"2026012115080536300_ehf213184-bib-0023","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1042\/BCJ20160095","article-title":"The leucine-rich repeat protein PRELP binds fibroblast cell-surface proteoglycans and enhances focal adhesion formation","volume":"473","author":"Bengtsson","year":"2016","journal-title":"Biochem J"},{"key":"2026012115080536300_ehf213184-bib-0024","doi-asserted-by":"crossref","first-page":"8092","DOI":"10.1074\/jbc.M111.291476","article-title":"PRELP protein inhibits the formation of the complement membrane attack complex","volume":"287","author":"Happonen","year":"2012","journal-title":"J Biol Chem"},{"key":"2026012115080536300_ehf213184-bib-0025","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s11897-017-0337-9","article-title":"Inflammation\u2014cause or consequence of heart failure or both?","volume":"14","author":"Van Linthout","year":"2017","journal-title":"Curr Heart Fail Rep"},{"key":"2026012115080536300_ehf213184-bib-0026","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0028578","article-title":"Complement C3 deficiency attenuates chronic hypoxia-induced pulmonary hypertension in mice","volume":"6","author":"Bauer","year":"2011","journal-title":"PLoS ONE"},{"key":"2026012115080536300_ehf213184-bib-0027","doi-asserted-by":"crossref","DOI":"10.1038\/srep42532","article-title":"The alternative complement pathway is dysregulated in patients with chronic heart failure","volume":"7","author":"Shahini","year":"2017","journal-title":"Sci Rep"},{"key":"2026012115080536300_ehf213184-bib-0028","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.molimm.2014.06.036","article-title":"A vital role for complement in heart disease","volume":"61","author":"Lappeg\u00e5rd","year":"2014","journal-title":"Mol Immunol"},{"key":"2026012115080536300_ehf213184-bib-0029","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1751-7133.2011.00248.x","article-title":"Transthoracic impedance accurately estimates pulmonary wedge pressure in patients with decompensated chronic heart failure","volume":"18","author":"Malfatto","year":"2012","journal-title":"Congest Heart Fail"},{"key":"2026012115080536300_ehf213184-bib-0030","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.immuni.2004.08.018","article-title":"Interleukin-17 family members and inflammation","volume":"21","author":"Kolls","year":"2004","journal-title":"Immunity"},{"key":"2026012115080536300_ehf213184-bib-0031","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1159\/000508255","article-title":"IL-17D: a less studied cytokine of IL-17 family","volume":"181","author":"Liu","year":"2020","journal-title":"Int Arch Allergy Immunol"},{"key":"2026012115080536300_ehf213184-bib-0032","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00314-2020","article-title":"IL-6 in pulmonary hypertension: why novel is not always best","volume":"55","author":"Toshner","year":"2020","journal-title":"Eur Respir J"},{"key":"2026012115080536300_ehf213184-bib-0033","article-title":"Clinical trial protocol for TRANSFORM-UK: a therapeutic open-label study of tocilizumab in the treatment of pulmonary arterial hypertension","volume":"8","author":"Hern\u00e1ndez-S\u00e1nchez","year":"2017","journal-title":"Pulm Circ"},{"key":"2026012115080536300_ehf213184-bib-0034","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01761-2019","article-title":"Cellular sources of interleukin-6 and associations with clinical phenotypes and outcomes in pulmonary arterial hypertension","volume":"55","author":"Simpson","year":"2020","journal-title":"Eur Respir J"},{"key":"2026012115080536300_ehf213184-bib-0035","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N Engl J Med"},{"key":"2026012115080536300_ehf213184-bib-0036","doi-asserted-by":"crossref","first-page":"24242","DOI":"10.1074\/jbc.M110.189365","article-title":"Decorin interacts with connective tissue growth factor (CTGF)\/CCN2 by LRR12 inhibiting its biological activity","volume":"286","author":"Vial","year":"2011","journal-title":"J Biol Chem"},{"key":"2026012115080536300_ehf213184-bib-0037","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2001868","article-title":"Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21","volume":"4","author":"Merline","year":"2011","journal-title":"Sci Signal"},{"key":"2026012115080536300_ehf213184-bib-0038","doi-asserted-by":"crossref","first-page":"6108","DOI":"10.4049\/jimmunol.1100373","article-title":"The role for decorin in delayed-type hypersensitivity","volume":"187","author":"Seidler","year":"2011","journal-title":"J Immunol"},{"key":"2026012115080536300_ehf213184-bib-0039","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S1734-1140(09)70004-0","article-title":"ICAM-1 signaling in endothelial cells","volume":"61","author":"Lawson","year":"2009","journal-title":"Pharmacol Rep"},{"key":"2026012115080536300_ehf213184-bib-0040","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1093\/eurheartj\/ehv512","article-title":"Left ventricular heart failure and pulmonary hypertension","volume":"37","author":"Rosenkranz","year":"2016","journal-title":"Eur Heart J"},{"key":"2026012115080536300_ehf213184-bib-0041","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1161\/CIRCHEARTFAILURE.113.000846","article-title":"Fibrosis marker syndecan-1 and outcome in patients with heart failure with reduced and preserved ejection fraction","volume":"7","author":"Tromp","year":"2014","journal-title":"Circ Heart Fail"},{"key":"2026012115080536300_ehf213184-bib-0042","doi-asserted-by":"crossref","DOI":"10.1111\/micc.12432","article-title":"Endovascular shedding markers in patients with heart failure with reduced ejection fraction: results from a single-center exploratory study","volume":"25","author":"Nijst","year":"2018","journal-title":"Microcirculation"},{"key":"2026012115080536300_ehf213184-bib-0043","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/ehf2.12560","article-title":"Prolargin and matrix metalloproteinase-2 in heart failure after heart transplantation and their association with haemodynamics","volume":"7","author":"Ahmed","year":"2020","journal-title":"ESC heart failure"},{"key":"2026012115080536300_ehf213184-bib-0044","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/14017431.2016.1185532","article-title":"Characteristics and survival of adult Swedish PAH and CTEPH patients 2000\u20132014","volume":"50","author":"R\u00e5degran","year":"2016","journal-title":"Scand Cardiovasc J"},{"key":"2026012115080536300_ehf213184-bib-0045","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.ijcard.2012.10.026","article-title":"Elderly patients diagnosed with idiopathic pulmonary arterial hypertension: results from the COMPERA registry","volume":"168","author":"Hoeper","year":"2013","journal-title":"Int J Cardiol"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ehf2.13184","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ehf2.13184","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/8\/2\/1230\/65926768\/eschf_8_2_1230.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/8\/2\/1230\/65926768\/eschf_8_2_1230.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T20:10:07Z","timestamp":1769026207000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/8\/2\/1230\/8381912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,5]]},"references-count":45,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,1,5]]},"published-print":{"date-parts":[[2021,4,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ehf2.13184","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,4]]},"published":{"date-parts":[[2021,1,5]]},"assertion":[{"value":"2020-08-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}