{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:22:50Z","timestamp":1785892970188,"version":"3.56.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":1772,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T00:00:00Z","timestamp":1613088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to evaluate the changes in left ventricular remodelling with time in patients with hypertrophic cardiomyopathy (HCM) using thallium-201 myocardial scintigraphy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Forty-eight patients with HCM participated in the study. The extent score (ES) and a newly devised index termed the \u2018mean count change\u2019 (MCC) were used to evaluate the myocardial perfusion defects. Using the amount of thallium-201 uptake (TU), MCC (%) was calculated using the following formula: (last TU \u2212 initial TU)\u2215initial TU \u00d7 100. To confirm the site of the lesion, the left ventricle was divided into five segments: anterior, septal, inferior, lateral, and apex. Cardiovascular complications and deaths were recorded. The mean follow-up period was 8.6 \u00b1 2.0 years. ES increased from 17.4 \u00b1 13.7% to 44.0 \u00b1 22.3% (P &amp;lt; 0.0001). MCC increased from 0% to 12.0 \u00b1 9.0% (P &amp;lt; 0.0001). The apex was the most frequent site of lesion. Twenty-seven patients (56.3%) had experienced left ventricular heart failure (LVHF). Both ES and MCC were greater in patients with LVHF than in those without LVHF. An overlap between the two groups was greater in ES than in MCC. Patients with LVHF had a higher incidence of atrial fibrillation and apoplexy. Nineteen patients (39.6%) died during the study period; 14 died from LVHF, 3 from sudden cardiac death, and 2 from cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Thallium-201 myocardial scintigraphy is useful for detecting the severity of myocardial damage and for confirming the lesion site in patients with HCM. MCC may be superior to ES in the evaluation of these changes with time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13218","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T09:10:30Z","timestamp":1613293830000},"page":"1378-1387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Predicting the Clinical Course in Hypertrophic Cardiomyopathy Using Thallium-201 Myocardial Scintigraphy"],"prefix":"10.1093","volume":"8","author":[{"given":"Mareomi","family":"Hamada","sequence":"first","affiliation":[{"name":"Division of Cardiology, Uwajima City Hospital , 1-1 Goten-machi, Uwajima, Ehime, 798-8510 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Shigematsu","sequence":"additional","affiliation":[{"name":"Department of Fundamental and Clinical Nursing, Ehime University Graduate School of Medicine , Toon ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Nakata","sequence":"additional","affiliation":[{"name":"Division of Radiology, Ehime University Graduate School of Medicine , Toon ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taishi","family":"Kuwahara","sequence":"additional","affiliation":[{"name":"Tokyo Heart Rhythm Clinic , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuntaro","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Integrated Medicine and Informatics, Ehime University Graduate School of Medicine , Toon ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyotaka","family":"Ohshima","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Uwajima City Hospital , 1-1 Goten-machi, Uwajima, Ehime, 798-8510 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiyoshi","family":"Ogimoto","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Uwajima City Hospital , 1-1 Goten-machi, Uwajima, Ehime, 798-8510 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,2,12]]},"reference":[{"key":"2026012115081614400_ehf213218-bib-0001","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1161\/01.CIR.50.3.436","article-title":"Differences in distribution of myocardial abnormalities in patients with obstructive and nonobstructive asymmetric septal hypertrophy (ASH). 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