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In addition, it is unknown whether they add any prognostic value to other well-known biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>In 969 stable coronary patients, we determined plasma levels of all the aforementioned components of mineral metabolism with a complete set of clinical and biochemical variables, including N-terminal pro-brain natriuretic peptide (NT-proBNP), high-sensitivity troponin I (hs-TnI), and high-sensitivity C-reactive protein. Secondary outcomes were ischaemic events (any acute coronary syndrome, stroke, or transient ischaemic attack) and heart failure or death. The primary outcome was a composite of the secondary outcomes. Median follow-up was 5.39 years. Age was 60 (52\u201372) years. Median glomerular filtration rate was 80.4 (65.3\u201393.1) mL\/min\/1.73 m2. One-hundred and eighty-five patients developed the primary outcome. FGF23, PTH, hs-TnI, and NT-proBNP were directly related with the primary outcome on univariate Cox analysis, while Klotho and calcidiol were inversely related. On multivariate analysis, only PTH (HR 1.058 [CI 1.021\u20131.097]; P = 0.002) and NT-proBNP (HR 1.020 [CI 1.012\u20131.028]; P &amp;lt; 0.001) were independent predictors of the primary outcome but also for the secondary outcome of heart failure or death (HR 1.066 [CI 1.016\u20131.119]; P = 0.009 and HR 1.024 [CI 1.014\u20131.034]; P &amp;lt; 0.001, respectively). PTH was the only biomarker that predicted ischaemic events (HR 1.052 [1.010\u20131.096]; P = 0.016). Patients were divided in two subgroups according to FGF23 plasma levels. PTH retained its prognostic value only in patients with FGF23 levels above the median (&amp;gt;85.5 RU\/mL) (P &amp;lt; 0.001) but not in patients with low FGF23 levels (P = 0.551). There was a significant interaction between FGF23 and PTH (P = 0.002). However, there was no significant interaction between PTH and both klotho and calcidiol levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Parathormone is an independent predictor of cardiovascular events in coronary patients, adding complimentary prognostic information to NT-proBNP plasma levels. This predictive value is restricted to patients with high FGF23 plasma levels. This should be considered in the design of future studies in this field.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13331","type":"journal-article","created":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T05:44:12Z","timestamp":1619847852000},"page":"2713-2722","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Parathormone Levels Add Prognostic Ability to N-Terminal Pro-Brain Natriuretic Peptide in Stable Coronary Patients"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5807-0894","authenticated-orcid":false,"given":"Carlos","family":"Guti\u00e9rrez-Landaluce","sequence":"first","affiliation":[{"name":"Department of Cardiology, Hospital Universitario de Fuenlabrada , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1lvaro","family":"Ace\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Cardiology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz , Avda. Reyes Cat\u00f3licos 2, Madrid, 28040 ,","place":["Spain"]},{"name":"Aut\u00f3noma University , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Pello","sequence":"additional","affiliation":[{"name":"Department of Cardiology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz , Avda. Reyes Cat\u00f3licos 2, Madrid, 28040 ,","place":["Spain"]},{"name":"Aut\u00f3noma University , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Mart\u00ednez-Milla","sequence":"additional","affiliation":[{"name":"Department of Cardiology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz , Avda. Reyes Cat\u00f3licos 2, Madrid, 28040 ,","place":["Spain"]},{"name":"Aut\u00f3noma University , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d3scar","family":"Gonz\u00e1lez-Lorenzo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz , Avda. Reyes Cat\u00f3licos 2, Madrid, 28040 ,","place":["Spain"]},{"name":"Aut\u00f3noma University , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nieves","family":"Tar\u00edn","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario de M\u00f3stoles , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Crist\u00f3bal","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario de Fuenlabrada , Madrid ,","place":["Spain"]},{"name":"Rey Juan Carlos University , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis M.","family":"Blanco-Colio","sequence":"additional","affiliation":[{"name":"Laboratory of Vascular Pathology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz , Madrid ,","place":["Spain"]},{"name":"CIBERCV , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Luis","family":"Mart\u00edn-Ventura","sequence":"additional","affiliation":[{"name":"Aut\u00f3noma University , Madrid ,","place":["Spain"]},{"name":"Laboratory of Vascular Pathology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz , Madrid ,","place":["Spain"]},{"name":"CIBERCV , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Huelmos","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario Fundaci\u00f3n Alcorc\u00f3n , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"L\u00f3pez-Castillo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz , Avda. Reyes Cat\u00f3licos 2, Madrid, 28040 ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaqu\u00edn","family":"Alonso","sequence":"additional","affiliation":[{"name":"Rey Juan Carlos University , Madrid ,","place":["Spain"]},{"name":"Department of Cardiology, Hospital de Getafe , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"L\u00f3pez Besc\u00f3s","sequence":"additional","affiliation":[{"name":"Rey Juan Carlos University , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Alonso-Pulp\u00f3n","sequence":"additional","affiliation":[{"name":"Aut\u00f3noma University , Madrid ,","place":["Spain"]},{"name":"Department of Cardiology, Hospital Puerta de Hierro , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Gonz\u00e1lez-Parra","sequence":"additional","affiliation":[{"name":"Aut\u00f3noma University , Madrid ,","place":["Spain"]},{"name":"Department of Nephrology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Egido","sequence":"additional","affiliation":[{"name":"Aut\u00f3noma University , Madrid ,","place":["Spain"]},{"name":"Laboratory of Vascular Pathology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz , Madrid ,","place":["Spain"]},{"name":"Department of Nephrology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz , Madrid ,","place":["Spain"]},{"name":"CIBERDEM , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Mah\u00edllo-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Research Unit, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d3scar","family":"Lorenzo","sequence":"additional","affiliation":[{"name":"Aut\u00f3noma University , Madrid ,","place":["Spain"]},{"name":"Laboratory of Vascular Pathology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz , Madrid ,","place":["Spain"]},{"name":"CIBERDEM , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Luisa","family":"Gonz\u00e1lez-Casaus","sequence":"additional","affiliation":[{"name":"Laboratory of Nephrology and Mineral Metabolism, Hospital G\u00f3mez-Ulla , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Tu\u00f1\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Cardiology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz , Avda. Reyes Cat\u00f3licos 2, Madrid, 28040 ,","place":["Spain"]},{"name":"Aut\u00f3noma University , Madrid ,","place":["Spain"]},{"name":"Laboratory of Vascular Pathology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz , Madrid ,","place":["Spain"]},{"name":"CIBERCV , Madrid ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,5,1]]},"reference":[{"key":"2026012114212572300_ehf213331-bib-0001","doi-asserted-by":"crossref","DOI":"10.1093\/ndt\/gfs534","article-title":"Vitamin D receptor activation and cardiovascular disease","volume":"27","author":"Gonzalez-Parra","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"2026012114212572300_ehf213331-bib-0002","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1161\/ATVBAHA.112.248039","article-title":"25-hydroxyvitamin d levels and risk of ischemic heart disease, myocardial infarction, and early death: population-based study and meta-analyses of 18 and 17 studies","volume":"32","author":"Br\u00f8ndum-Jacobsen","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026012114212572300_ehf213331-bib-0003","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1042\/BJ20041799","article-title":"Role of the vitamin D receptor in FGF23 action on phosphate metabolism","volume":"390","author":"Inoue","year":"2005","journal-title":"Biochem J"},{"key":"2026012114212572300_ehf213331-bib-0004","doi-asserted-by":"crossref","first-page":"640","DOI":"10.7326\/0003-4819-152-10-201005180-00004","article-title":"The associations of fibroblast growth factor 23 and uncarboxylated matrix Gla protein with mortality in coronary artery disease: the Heart and Soul Study","volume":"152","author":"Parker","year":"2010","journal-title":"Ann Intern Med"},{"key":"2026012114212572300_ehf213331-bib-0005","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1172\/JCI46122","article-title":"FGF23 induces left ventricular hypertrophy","volume":"121","author":"Faul","year":"2011","journal-title":"J Clin Invest"},{"key":"2026012114212572300_ehf213331-bib-0006","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/j.jacc.2011.03.069","article-title":"Vitamin D, parathyroid hormone, and cardiovascular events among older adults","volume":"58","author":"Kestenbaum","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"2026012114212572300_ehf213331-bib-0007","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ahj.2011.05.005","article-title":"Parathyroid hormone, vitamin D, renal dysfunction, and cardiovascular disease: dependent or independent risk factors?","volume":"162","author":"Anderson","year":"2011","journal-title":"Am Heart J"},{"key":"2026012114212572300_ehf213331-bib-0008","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s12603-015-0649-y","article-title":"Parathormone levels are independently associated with the presence of left ventricular hypertrophy in patients with coronary artery disease","volume":"20","author":"Ace\u00f1a","year":"2016","journal-title":"J Nutr Health Aging"},{"key":"2026012114212572300_ehf213331-bib-0009","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1097\/HJH.0b013e3282ffb43b","article-title":"Parathyroid hormone and the risk of incident hypertension","volume":"26","author":"Taylor","year":"2008","journal-title":"J Hypertens"},{"key":"2026012114212572300_ehf213331-bib-0010","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/36285","article-title":"Mutation of the mouse klotho gene leads to a syndrome resembling ageing","volume":"390","author":"Kuro-o","year":"1997","journal-title":"Nature"},{"key":"2026012114212572300_ehf213331-bib-0011","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1681\/ASN.2007080854","article-title":"Mechanisms of vascular calcification in chronic kidney disease","volume":"19","author":"Moe","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"2026012114212572300_ehf213331-bib-0012","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.amjcard.2013.10.012","article-title":"Usefulness of a combination of monocyte chemoattractant protein-1, galectin-3, and N-terminal probrain natriuretic peptide to predict cardiovascular events in patients with coronary artery disease","volume":"113","author":"Tu\u00f1\u00f3n","year":"2014","journal-title":"Am J Cardiol"},{"key":"2026012114212572300_ehf213331-bib-0013","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/ejhf.592","article-title":"ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). 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