{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:09:35Z","timestamp":1769083775328,"version":"3.49.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":1719,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T00:00:00Z","timestamp":1617667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The objective of this study was to investigate the prognostic value of urinary N-terminal pro-brain natriuretic peptide (NT-proBNP) compared with plasma NT-proBNP in patients presenting with acute chest pain in the emergency department.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We measured simultaneously plasma and urinary NT-proBNP at admission in 301 patients with acute chest pain. In our cohort, 174 patients suffered from acute coronary syndrome (ACS). A follow-up (median of 55 months) was performed regarding the endpoints all-cause mortality and major adverse cardiac events (mortality, congestive heart failure, ACS with the necessity of a coronary intervention, and stroke). Fifty-four patients died during follow-up; 98 suffered from the combined endpoint. A significant and positive correlation of urinary and plasma NT-proBNP was found (r = 0.87, P &amp;lt; 0.05). Patients with troponin positive ACS had significantly elevated levels of plasma and urinary NT-proBNP compared with those with unstable angina pectoris or chest wall syndrome (each P &amp;lt; 0.05). The highest levels of both biomarkers were found in patients with congestive heart failure (each P &amp;lt; 0.05). According to Kaplan\u2013Meier analysis, plasma and urinary NT-proBNP were significant predictors for mortality and the combined endpoint in the whole study cohort and in the subgroup of patients with ACS (each P &amp;lt; 0.05). Regarding Cox regression analysis, plasma and urinary NT-proBNP were independent predictors for mortality and the combined endpoint (each P &amp;lt; 0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Urinary NT-proBNP seems to provide a significant predictive value regarding the endpoints all-cause mortality and major adverse cardiac events in patients with acute chest pain and those with ACS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13332","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T08:04:22Z","timestamp":1617696262000},"page":"2293-2305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Urinary N-Terminal Pro-Brain Natriuretic Peptide: Prognostic Value in Patients with Acute Chest Pain"],"prefix":"10.1093","volume":"8","author":[{"given":"Stefanie","family":"Reynen","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II (Cardiology), University Hospital Regensburg , Franz-Josef-Strauss-Allee 11, Regensburg, 93053 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Schlossbauer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II (Cardiology), University Hospital Regensburg , Franz-Josef-Strauss-Allee 11, Regensburg, 93053 ,","place":["Germany"]},{"name":"Department of Anesthesiology, Hospital Barmherzige Br\u00fcder Regensburg , Regensburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ute","family":"Hubauer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II (Cardiology), University Hospital Regensburg , Franz-Josef-Strauss-Allee 11, Regensburg, 93053 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Hupf","sequence":"additional","affiliation":[{"name":"Emergency Department, University Hospital Regensburg , Regensburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arno","family":"Mohr","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II (Cardiology), University Hospital Regensburg , Franz-Josef-Strauss-Allee 11, Regensburg, 93053 ,","place":["Germany"]},{"name":"Department of Pneumology, Donaustauf Hospital , Donaustauf ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyn","family":"Orso","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg , Regensburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Emergency Department, University Hospital Regensburg , Regensburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Luchner","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Barmherzige Br\u00fcder Regensburg , Regensburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars S.","family":"Maier","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II (Cardiology), University Hospital Regensburg , Franz-Josef-Strauss-Allee 11, Regensburg, 93053 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Wallner","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg , Regensburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten G.","family":"Jungbauer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II (Cardiology), University Hospital Regensburg , Franz-Josef-Strauss-Allee 11, Regensburg, 93053 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,4,6]]},"reference":[{"key":"2026012114032827500_ehf213332-bib-0001","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ejheart.2003.10.003","article-title":"N-terminal pro-brain natriuretic peptide for discriminating between cardiac and non-cardiac dyspnoea","volume":"6","author":"Nielsen","year":"2004","journal-title":"Eur J Heart Fail"},{"key":"2026012114032827500_ehf213332-bib-0002","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1046\/j.1365-2265.1997.2361058.x","article-title":"Immunoreactive 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