{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T07:00:21Z","timestamp":1774854021882,"version":"3.50.1"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":1726,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T00:00:00Z","timestamp":1617062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministry of Health of Czech Republic","doi-asserted-by":"publisher","award":["15-27109A"],"award-info":[{"award-number":["15-27109A"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["15\u201027109A"],"award-info":[{"award-number":["15\u201027109A"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Analysis of microvascular parameters in the retinal circulation\u2014known to reflect those in the systemic circulation\u2014allows us to differentiate between eutrophic and hypertrophic remodelling of small arteries. This study aimed to examine microvascular changes in patients with congestive heart failure (CHF) and reduced as well as mid-range ejection fraction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Forty subjects with CHF underwent measurement of retinal capillary flow (RCF), wall-to-lumen ratio (WLR), vessel and lumen diameter, wall thickness, and wall cross-sectional area (WCSA) of retinal arterioles of the right eye by scanning laser Doppler flowmetry (SLDF). Applying a matched pair approach, we compared this group with reference values of age-matched controls from a random sample in the population of Pilsen, Czech Republic. There was no significant difference in RCF and WLR between the groups (RCF: P = 0.513; WLR: P = 0.106). In contrast, wall thickness and WCSA, indicators of hypertrophic remodelling, were higher in CHF subjects (WT: 15.0 \u00b1 4.2 vs. 12.7 \u00b1 4.2 \u03bcm, P = 0.021; WCSA: 4437.6 \u00b1 1314.5 vs. 3615.9 \u00b1 1567.8 \u03bcm2, P = 0.014). Similarly, vessel (109.4 \u00b1 11.1 vs. 100.5 \u00b1 14.4 \u03bcm, P = 0.002) and lumen diameter (79.0 \u00b1 7.9 vs. 75.2 \u00b1 8.5 \u03bcm, P = 0.009) were increased in CHF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In CHF subjects, we observed hypertrophic remodelling of retinal arterioles indicative of similar changes of small resistance arteries in the systemic circulation. Microvascular structure and function assessed by SLDF may thereby represent a useful, non-invasive method for monitoring of microvascular damage in patients with CHF and may offer innovative treatment targets for new CHF therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13334","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T21:45:25Z","timestamp":1617140725000},"page":"1892-1900","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hypertrophic Remodelling of Retinal Arterioles in Patients with Congestive Heart Failure"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4031-6304","authenticated-orcid":false,"given":"Susanne","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Nephrology and Hypertension, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) , Ulmenweg 18, Erlangen, 91054 ,","place":["Germany"]},{"name":"Department of Cardiology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) , Erlangen ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Kolwelter","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) , Ulmenweg 18, Erlangen, 91054 ,","place":["Germany"]},{"name":"Department of Cardiology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) , Erlangen ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnes","family":"Bosch","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) , Ulmenweg 18, Erlangen, 91054 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"C\u00edfkov\u00e1","sequence":"additional","affiliation":[{"name":"Center for Cardiovascular Prevention of the First Faculty of Medicine, Charles University and Thomayer Hospital , Prague ,","place":["Czech Republic"]},{"name":"Department of Medicine II, Charles University in Prague, First Faculty of Medicine , Prague ,","place":["Czech Republic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna M.","family":"Harazny","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) , Ulmenweg 18, Erlangen, 91054 ,","place":["Germany"]},{"name":"Department of Human Physiology and Pathophysiology, University of Warmia and Mazury , Olsztyn ,","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Ott","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) , Ulmenweg 18, Erlangen, 91054 ,","place":["Germany"]},{"name":"Department of Nephrology and Hypertension, Paracelsus Medical School , Nuremberg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Achenbach","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) , Erlangen ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland E.","family":"Schmieder","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension, University Hospital Erlangen, Friedrich-Alexander-University 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