{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:39:40Z","timestamp":1769085580375,"version":"3.49.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":1694,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Ratchadapisek Sompoch Endowment Fund (2018), Chulalongkorn University","award":["RA 61\/117"],"award-info":[{"award-number":["RA 61\/117"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We sought to examine clinical characteristics and outcomes in patients hospitalized for acute heart failure (HF) and thyrotoxicosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with thyrotoxic HF were compared with age and gender-matched patients hospitalized for acute HF (controls). Thyr-HF was defined by the Framingham criteria for HF and clinical hyperthyroidism. Thyrotoxic cardiomyopathy was defined as left ventricular ejection fraction (LVEF) &amp;lt; 55%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 11 109 consecutive patients hospitalized for acute HF between 1 January 2002 and 1 January 2017, 92 patients (0.8%) had thyrotoxic HF. Clinical and echocardiographic data were available in 87 patients (age 51 \u00b1 16 years; 74% female), representing the study population. Compared with controls, patients with Thyr-HF had a smaller body surface area (BSA), a higher LVEF, a lower LV end-diastolic diameter, a higher tricuspid annular plane systolic excursion (TAPSE), higher blood pressure, higher heart rate, and were more likely to have right-sided HF at presentation (P &amp;lt; 0.01 for all). The survival rate among patients with thyrotoxic HF was higher than the control group (HR: 4.3; 95% CI: 2.1\u20139.5). Fifty-eight percent of patients with thyrotoxic HF had thyrotoxic cardiomyopathy. In multivariate analysis, TAPSE (OR = 46; 95% CI: 1.04\u20132008.20; P = 0.047) and leukocytosis (OR = 16; 95% CI 1.01\u2013259.39; P = 0.049) correlated with thyrotoxic cardiomyopathy. LV recovery was observed in 69% of these patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Thyrotoxic HF was uncommon among patients hospitalized for acute HF. However, after definitive therapy, these patients had a more favourable prognosis than those hospitalized for acute HF without thyrotoxic HF. Clinical phenotypes of thyrotoxic HF include small BSA, middle-aged female, HF-pEF, and right-sided HF. Thyrotoxic cardiomyopathy affected over half of the patients with thyrotoxic HF with a two-third recovery rate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13347","type":"journal-article","created":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T05:39:44Z","timestamp":1619847584000},"page":"2776-2783","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical Phenotypes and Prognosis of Thyrotoxic Heart Failure and Cardiomyopathy in Patients Hospitalized for Acute Heart Failure"],"prefix":"10.1093","volume":"8","author":[{"given":"Weerapat","family":"Kositanurit","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University , Bhumisiri Mangkhalanusorn Building, M Floor, Zone C, 1873 Rama IV Rd, Bangkok, Pathumwan, 10330 ,","place":["Thailand"]},{"name":"Cardiac Center, King Chulalongkorn Memorial Hospital, Thai Red Cross Society , Bangkok ,","place":["Thailand"]},{"name":"Department of Physiology, Faculty of Medicine, Chulalongkorn University , Bangkok ,","place":["Thailand"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veraprapas","family":"Kittipibul","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University , Bhumisiri Mangkhalanusorn Building, M Floor, Zone C, 1873 Rama IV Rd, Bangkok, Pathumwan, 10330 ,","place":["Thailand"]},{"name":"Cardiac Center, King Chulalongkorn Memorial Hospital, Thai Red Cross Society , Bangkok ,","place":["Thailand"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panudda","family":"Srichomkwun","sequence":"additional","affiliation":[{"name":"Cardiac Center, King Chulalongkorn Memorial Hospital, Thai Red Cross Society , Bangkok ,","place":["Thailand"]},{"name":"Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Chulalongkorn University , Bangkok ,","place":["Thailand"]},{"name":"Excellent Center in Diabetes, Hormones and Metabolism, King Chulalongkorn Memorial Hospital, Thai Red Cross Society , Bangkok ,","place":["Thailand"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smonporn","family":"Boonyaratavej","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University , Bhumisiri Mangkhalanusorn Building, M Floor, Zone C, 1873 Rama IV Rd, Bangkok, Pathumwan, 10330 ,","place":["Thailand"]},{"name":"Cardiac Center, King Chulalongkorn Memorial Hospital, Thai Red Cross Society , Bangkok ,","place":["Thailand"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7090-9947","authenticated-orcid":false,"given":"Sarinya","family":"Puwanant","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University , Bhumisiri Mangkhalanusorn Building, M Floor, Zone C, 1873 Rama IV Rd, Bangkok, Pathumwan, 10330 ,","place":["Thailand"]},{"name":"Cardiac Center, King Chulalongkorn Memorial Hospital, Thai Red Cross Society , Bangkok ,","place":["Thailand"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,5,1]]},"reference":[{"key":"2026012114214895100_ehf213347-bib-0001","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1161\/CIRCULATIONAHA.106.678326","article-title":"Thyroid disease and the heart","volume":"116","author":"Klein","year":"2007","journal-title":"Circulation"},{"key":"2026012114214895100_ehf213347-bib-0002","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1056\/NEJM200102153440707","article-title":"Thyroid hormone and the cardiovascular system","volume":"344","author":"Klein","year":"2001","journal-title":"N Engl J Med"},{"key":"2026012114214895100_ehf213347-bib-0003","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s11897-008-0026-9","article-title":"Thyrotoxic cardiac disease","volume":"5","author":"Dahl","year":"2008","journal-title":"Curr Heart Fail Rep"},{"key":"2026012114214895100_ehf213347-bib-0004","doi-asserted-by":"crossref","first-page":"68","DOI":"10.14740\/cr1034","article-title":"Thyroid and Cardiovascular Disease: A Focused Review on the Impact of Hyperthyroidism in Heart Failure","volume":"11","author":"Khan","year":"2020","journal-title":"Cardiol Res"},{"key":"2026012114214895100_ehf213347-bib-0005","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.jacc.2016.05.043","article-title":"High-Output Heart Failure: A 15-Year Experience","volume":"68","author":"Reddy","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"2026012114214895100_ehf213347-bib-0006","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.118.005266","article-title":"Thyroid Dysfunction in Heart Failure and Cardiovascular Outcomes","volume":"11","author":"Kannan","year":"2018","journal-title":"Circ Heart Fail"},{"key":"2026012114214895100_ehf213347-bib-0007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.hfc.2019.08.002","article-title":"Thyroid abnormalities in heart failure","volume":"16","author":"Danzi","year":"2020","journal-title":"Heart Fail Clin"},{"key":"2026012114214895100_ehf213347-bib-0008","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1046\/j.1365-2125.1998.00804.x","article-title":"Heart failure in thyrotoxicosis, an approach to management","volume":"46","author":"Choudhury","year":"1998","journal-title":"Br J Clin Pharmacol"},{"key":"2026012114214895100_ehf213347-bib-0009","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1136\/hrt.81.4.444","article-title":"Dilated cardiomyopathy in thyrotoxicosis","volume":"81","author":"Goland","year":"1999","journal-title":"Heart"},{"key":"2026012114214895100_ehf213347-bib-0010","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0002-9629(15)41663-5","article-title":"Case report: reversible mitral regurgitation and congestive heart failure complicating thyrotoxicosis","volume":"311","author":"Cavros","year":"1996","journal-title":"Am J Med Sci"},{"key":"2026012114214895100_ehf213347-bib-0011","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1089\/thy.2006.16.813","article-title":"Reversible severe tricuspid regurgitation with right heart failure associated with thyrotoxicosis","volume":"16","author":"Park","year":"2006","journal-title":"Thyroid"},{"key":"2026012114214895100_ehf213347-bib-0012","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.resuscitation.2005.09.002","article-title":"Pulmonary hypertension and predominant right heart failure in thyrotoxicosis","volume":"69","author":"Paran","year":"2006","journal-title":"Resuscitation"},{"key":"2026012114214895100_ehf213347-bib-0013","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1056\/NEJM197112232852601","article-title":"The natural history of congestive heart failure: the Framingham study","volume":"285","author":"McKee","year":"1971","journal-title":"N Engl J Med"},{"key":"2026012114214895100_ehf213347-bib-0014","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S0140-6736(16)00278-6","article-title":"Hyperthyroidism","volume":"388","author":"De Leo","year":"2016","journal-title":"Lancet"},{"key":"2026012114214895100_ehf213347-bib-0015","volume-title":"Manual of Diagnostic Laboratories","author":"Center for Medical Diagnostic Laboratories Faculty of Medicine Chulalongkorn University","year":"2020"},{"key":"2026012114214895100_ehf213347-bib-0016","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1111\/cen.12371","article-title":"Reference ranges of serum TSH, FT4 and thyroid autoantibodies in the Thai population: the national health examination survey","volume":"80","author":"Sriphrapradang","year":"2014","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2026012114214895100_ehf213347-bib-0017","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1089\/thy.2016.0229","article-title":"2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis","volume":"26","author":"Ross","year":"2016","journal-title":"Thyroid"},{"key":"2026012114214895100_ehf213347-bib-0018","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1089\/thy.2011.0334","article-title":"Diagnostic criteria, clinical features, and incidence of thyroid storm based on nationwide surveys","volume":"22","author":"Akamizu","year":"2012","journal-title":"Thyroid"},{"key":"2026012114214895100_ehf213347-bib-0019","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1089\/thy.2017.0243","article-title":"Thyroid storm: a Japanese perspective","volume":"28","author":"Akamizu","year":"2018","journal-title":"TThyroid"},{"key":"2026012114214895100_ehf213347-bib-0020","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1177\/0885066613498053","article-title":"Thyroid storm: an updated review","volume":"30","author":"Chiha","year":"2015","journal-title":"J Intensive Care Med"},{"key":"2026012114214895100_ehf213347-bib-0021","doi-asserted-by":"crossref","first-page":"e578","DOI":"10.1161\/CIR.0000000000000560","article-title":"Evaluation and Management of Right-Sided Heart Failure: A Scientific Statement From the American Heart Association","volume":"137","author":"Konstam","year":"2018","journal-title":"Circulation"},{"key":"2026012114214895100_ehf213347-bib-0022","volume-title":"Cardiomyopathies - From Basic Research to Clinical Management Cardiomyopathies - From Basic Research to Clinical Management","author":"Babenko","year":"2012"},{"key":"2026012114214895100_ehf213347-bib-0023","doi-asserted-by":"crossref","first-page":"452709","DOI":"10.1155\/2013\/452709","article-title":"Determinants of thyrotoxic cardiomyopathy recovery","volume":"2013","author":"Oliveros-Ruiz","year":"2013","journal-title":"Biomed Res Int"},{"key":"2026012114214895100_ehf213347-bib-0024","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","article-title":"2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC","volume":"37","author":"Ponikowski","year":"2016","journal-title":"Eur Heart J"},{"key":"2026012114214895100_ehf213347-bib-0025","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.echo.2010.05.010","article-title":"Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography","volume":"23","author":"Rudski","year":"2010","journal-title":"J Am Soc Echocardiogr"},{"key":"2026012114214895100_ehf213347-bib-0026","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1016\/j.jacc.2009.04.011","article-title":"Diagnosis and assessment of pulmonary arterial hypertension","volume":"54","author":"Badesch","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"2026012114214895100_ehf213347-bib-0027","first-page":"347","article-title":"The nature and prognosis of heart disease in thyrotoxicosis. A review of 150 patients treated with 131 I","volume":"28","author":"Sandler","year":"1959","journal-title":"Q J Med"},{"key":"2026012114214895100_ehf213347-bib-0028","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/j.0954-6820.1961.tb07877.x","article-title":"Thyrotoxicosis and Heart Disease","volume":"169","author":"Summers","year":"1961","journal-title":"Acta Med Scand"},{"key":"2026012114214895100_ehf213347-bib-0029","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1046\/j.1365-2796.1997.00191.x","article-title":"Hyperthyroidism and pulmonary hypertension","volume":"242","author":"Thurnheer","year":"1997","journal-title":"J Intern Med"},{"key":"2026012114214895100_ehf213347-bib-0030","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ejim.2005.11.023","article-title":"Pulmonary hypertension is frequent in hyperthyroidism and normalizes after therapy","volume":"17","author":"Marvisi","year":"2006","journal-title":"Eur J Intern Med"},{"key":"2026012114214895100_ehf213347-bib-0031","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.jacc.2016.05.036","article-title":"High-output heart failure revisited","volume":"68","author":"Anand","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"2026012114214895100_ehf213347-bib-0032","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1136\/hrt.2006.100628","article-title":"Incidence, clinical characteristics and outcome of congestive heart failure as the initial presentation in patients with primary hyperthyroidism","volume":"93","author":"Siu","year":"2007","journal-title":"Heart"},{"key":"2026012114214895100_ehf213347-bib-0033","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/01.RES.44.1.1","article-title":"Stimulation of cardiac myosin adenosine triphosphatase in thyrotoxicosis","volume":"44","author":"Morkin","year":"1979","journal-title":"Circ Res"},{"key":"2026012114214895100_ehf213347-bib-0034","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.ecl.2006.09.008","article-title":"Thyrotoxicosis and thyroid storm","volume":"35","author":"Nayak","year":"2006","journal-title":"Endocrinol Metab Clin North Am"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ehf2.13347","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ehf2.13347","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/8\/4\/2776\/65569816\/eschf_8_4_2776.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/8\/4\/2776\/65569816\/eschf_8_4_2776.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T19:26:48Z","timestamp":1769023608000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/8\/4\/2776\/8344476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,1]]},"references-count":34,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,5,1]]},"published-print":{"date-parts":[[2021,8,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ehf2.13347","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,8]]},"published":{"date-parts":[[2021,5,1]]},"assertion":[{"value":"2020-12-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}