{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:25:54Z","timestamp":1769084754574,"version":"3.49.0"},"reference-count":83,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":1677,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Heart failure (HF) does not occur in a vacuum and is commonly defined and exacerbated by its co-morbid conditions. Neurohormonal imbalance and systemic inflammation are some of the key pathomechanisms of HF but also commonly encountered co-morbidities such as arterial hypertension, diabetes mellitus, cachexia, obesity and sleep-disordered breathing. A cornerstone of HF management is neurohormonal blockade, which in HF with reduced ejection fraction has been tied to a reduction in morbidity and mortality. Pharmacological treatment effective in patients with HF with reduced ejection fraction did not show substantial effects in HF with preserved ejection fraction. Here, we review novel device-based therapies using neuromodulation of extra-cardiac targets to treat cardiometabolic disease.<\/jats:p>","DOI":"10.1002\/ehf2.13361","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T06:44:00Z","timestamp":1621320240000},"page":"3327-3338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Extra-Cardiac Targets in the Management of Cardiometabolic Disease: Device-Based Therapies"],"prefix":"10.1093","volume":"8","author":[{"given":"Ana","family":"Jorbenadze","sequence":"first","affiliation":[{"name":"Tbilisi Heart and Vascular Clinic , Tbilisi ,","place":["Georgia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marat","family":"Fudim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Duke University Medical Center , Durham, NC ,","place":["USA"]},{"name":"Duke Clinical Research Institute , Durham, NC ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Mahfoud","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Cardiology, Angiology, and Intensive Care Medicine, Saarland University , Saarbr\u00fccken ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip B.","family":"Adamson","sequence":"additional","affiliation":[{"name":"Abbott , Los Angeles, CA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek","family":"Bekfani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Division of Cardiology, Angiology and Intensive Medical Care, University Hospital Magdeburg, Otto von Guericke University , Magdeburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf","family":"Wachter","sequence":"additional","affiliation":[{"name":"Clinic and Polyclinic for Cardiology, University Hospital Leipzig , Leipzig ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horst","family":"Sievert","sequence":"additional","affiliation":[{"name":"CardioVascular Center Frankfurt , Frankfurt ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr P.","family":"Ponikowski","sequence":"additional","affiliation":[{"name":"Centre for Heart Diseases, University Hospital , Wroclaw ,","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John G. 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