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Institute","doi-asserted-by":"publisher","award":["K12\u2010CA133250"],"award-info":[{"award-number":["K12\u2010CA133250"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Improved cancer survivorship has led to a higher number of anthracycline-induced cardiomyopathy patients with end-stage heart failure. We hypothesize that outcomes following continuous-flow LVAD (CF-LVAD) implantation in those with anthracycline-induced cardiomyopathy are comparable with other aetiologies of cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Using the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) from 2008 to 2017, we identified patients with anthracycline-induced cardiomyopathy who received a CF-LVAD and compared them with those with idiopathic dilated (IDM) and ischaemic cardiomyopathies (ICM). Mortality was studied using the Cox proportional hazards model. Other adverse events were evaluated using competing risk models. Overall, 248 anthracycline-induced cardiomyopathy patients underwent CF-LVAD implantation, with a median survival of 48 months, an improvement compared with those before 2012 [adjusted hazards ratio (aHR): 0.53; confidence interval (CI): 0.33\u20130.86]. At 12 months, 85.1% of anthracycline-induced cardiomyopathy, 86.0% of IDM, and 80.2% of ICM patients were alive (anthracycline-induced cardiomyopathy vs. IDM: aHR: 1.12; CI: 0.88\u20131.43 and anthracycline-induced cardiomyopathy vs. ICM: aHR: 0.98; CI: 0.76\u20131.28). Anthracycline-induced cardiomyopathy patients had a higher major bleeding risk compared with IDM patients (aHR: 1.23; CI: 1.01\u20131.50), and a lower risk of stroke and prolonged respiratory support compared to ICM patients (aHR: 0.31 and 0.67 respectively; both P &amp;lt; 0.05). There was no difference in the risk of major infection, acute kidney injury, and venous thromboembolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>After receiving a CF-LVAD, survival in patients with anthracycline-induced cardiomyopathy is similar to those with ICM or IDM. Further research into differential secondary endpoints-related disparities is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13362","type":"journal-article","created":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T06:40:31Z","timestamp":1620888031000},"page":"2866-2875","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Outcomes in Patients with Anthracycline-Induced Cardiomyopathy Undergoing Left Ventricular Assist Devices Implantation"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0253-1174","authenticated-orcid":false,"given":"Avirup","family":"Guha","sequence":"first","affiliation":[{"name":"Harrington Heart and Vascular Institute, Case Western Reserve University , Cleveland, OH ,","place":["USA"]},{"name":"Cardio-Oncology Program, Division of Cardiology, The Ohio State University Medical Center , Columbus, OH ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar","family":"Caraballo","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Yale School of Medicine , New Haven, CT ,","place":["USA"]},{"name":"Center for Outcomes Research and Evaluation , New Haven, CT ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prantesh","family":"Jain","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology, University Hospitals Cleveland Medical Center, Seidman Cancer Center at Case Comprehensive Cancer Center, Case Western Reserve University , Cleveland, OH ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Elliott","family":"Miller","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Yale School of Medicine , New Haven, CT ,","place":["USA"]},{"name":"Yale National Clinician Scholars Program , New Haven, CT ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn","family":"Owusu-Guha","sequence":"additional","affiliation":[{"name":"Pharmacy Department, OhioHealth Riverside Methodist Hospital , Columbus, OH ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A.A.","family":"Clark","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Yale School of Medicine , New Haven, CT ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Velazquez","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Yale School of Medicine , New Haven, CT ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Yale School of Medicine , New Haven, CT ,","place":["USA"]},{"name":"Center for Outcomes Research and Evaluation , New Haven, CT ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren A.","family":"Baldassarre","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Yale School of Medicine , New Haven, CT ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Addison","sequence":"additional","affiliation":[{"name":"Cardio-Oncology Program, Division of Cardiology, The Ohio State University Medical Center , Columbus, OH ,","place":["USA"]},{"name":"Cancer Control Program, Department of Medicine, Ohio State University Comprehensive Cancer Center , Columbus, OH ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal L.","family":"Weintraub","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, and Vascular Biology Center, Medical College of Georgia at Augusta University , Augusta, GA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihar R.","family":"Desai","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine, Yale School of Medicine , New Haven, CT ,","place":["USA"]},{"name":"Center for Outcomes Research and Evaluation , New Haven, CT ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,5,13]]},"reference":[{"key":"2026012114205636500_ehf213362-bib-0001","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1056\/NEJM197902083000603","article-title":"Serial assessment of doxorubicin cardiotoxicity with quantitative radionuclide angiocardiography","volume":"300","author":"Alexander","year":"1979","journal-title":"N Engl J Med"},{"key":"2026012114205636500_ehf213362-bib-0002","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.jacc.2009.02.050","article-title":"Cardiovascular complications of cancer therapy: incidence, pathogenesis, diagnosis, and management","volume":"53","author":"Yeh","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"2026012114205636500_ehf213362-bib-0003","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1056\/NEJM200004133421502","article-title":"Underlying causes and long-term survival in patients with initially unexplained cardiomyopathy","volume":"342","author":"Felker","year":"2000","journal-title":"N Engl J Med"},{"key":"2026012114205636500_ehf213362-bib-0004","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1002\/ejhf.1049","article-title":"Comparison of long-term outcome in anthracycline-related versus idiopathic dilated cardiomyopathy: a single centre experience","volume":"20","author":"Fornaro","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"2026012114205636500_ehf213362-bib-0005","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.jacc.2017.04.025","article-title":"2017 ACC\/AHA\/HFSA Focused Update of the 2013 ACCF\/AHA Guideline for the Management of Heart Failure. 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