{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:30:45Z","timestamp":1787668245132,"version":"build-2736575974"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":1690,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Cordio Medical Ltd."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to assess the ability of a voice analysis application to discriminate between wet and dry states in chronic heart failure (CHF) patients undergoing regular scheduled haemodialysis treatment due to volume overload as a result of their chronic renal failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>In this single-centre, observational study, five patients with CHF, peripheral oedema of \u22652, and pulmonary congestion-related dyspnoea, undergoing haemodialysis three times per week, recorded five sentences into a standard smartphone\/tablet before and after haemodialysis. Recordings were provided that same noon\/early evening and the next morning and evening. Patient weight was measured at the hospital before and after each haemodialysis session. Recordings were analysed by a smartphone application (app) algorithm, to compare speech measures (SMs) of utterances collected over time. On average, patients provided recordings throughout 25.8 \u00b1 3.9 dialysis treatment cycles, resulting in a total of 472 recordings. Weight changes of 1.95 \u00b1 0.64 kg were documented during cycles. Median baseline SM prior to dialysis was 0.87 \u00b1 0.17, and rose to 1.07 \u00b1 0.15 following the end of the dialysis session, at noon (P = 0.0355), and remained at a similar level until the following morning (P = 0.007). By the evening of the day following dialysis, SMs returned to baseline levels (0.88 \u00b1 0.19). Changes in patient weight immediately after dialysis positively correlated with SM changes, with the strongest correlation measured the evening of the dialysis day [slope: \u22120.40 \u00b1 0.15 (95% confidence interval: \u22120.71 to \u22120.10), P = 0.0096].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The fluid-controlled haemodialysis model demonstrated the ability of the app algorithm to identify cyclic changes in SMs, which reflected bodily fluid levels. The voice analysis platform bears considerable potential as a harbinger of impending fluid overload in a range of clinical scenarios, which will enhance monitoring and triage efforts, ultimately optimizing remote CHF management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13367","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T15:43:04Z","timestamp":1620315784000},"page":"2467-2472","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Feasibility of Remote Speech Analysis in Evaluation of Dynamic Fluid Overload in Heart Failure Patients Undergoing Haemodialysis Treatment"],"prefix":"10.1093","volume":"8","author":[{"given":"Offer","family":"Amir","sequence":"first","affiliation":[{"name":"Department of Cardiology, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem , Jerusalem ,","place":["Israel"]},{"name":"Azrieli Faculty of Medicine, 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