{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:01:38Z","timestamp":1790024498209,"version":"4.0.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":1591,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:00:00Z","timestamp":1628726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aims to establish the feasibility, safety, and efficacy of outpatient intravenous (IV) diuretic treatment for the management of decompensated heart failure (HF) for patients enrolled in the HeartFailure@Home service.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We retrospectively analysed the clinical episodes of decompensated HF for patients enrolled in the HeartFailure@Home service, managed by ambulatory IV diuretic treatment either at home or on a day-case unit. A control group consisting of HF patients admitted to hospital for IV diuretics (standard-of-care) was also evaluated. In total, 203 episodes of decompensated HF (n = 154 patients) were evaluated. One hundred and fourteen episodes in 79 patients were managed exclusively by the ambulatory IV diuretic service\u201478 (68.4%) on a day-case unit and 36 (31.6%) domiciliary; 84.1% of patient episodes under the HF@Home service were successfully managed entirely in an out-patient setting without hospitalization. Eleven patients required admission in order to administer higher doses of IV diuretics than could be provided in the ambulatory setting. During follow-up, there were 20 (17.5%) 30 day re-admissions with HF or death in the ambulatory IV group and 29 (32.6%) in the standard-of-care arm (P = 0.02). There was no difference in 30 day HF readmissions between the two groups (14.9% ambulatory vs. 13.5% inpatients, P = 0.8), but 30 day mortality was significantly lower in the ambulatory group (3.5% vs. 21.3% inpatients, P &amp;lt; 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Outpatient ambulatory management of decompensated HF with IV diuretics given either on a day case unit or in a domiciliary setting is feasible, safe, and effective in selected patients with decompensated HF. This should be explored further as a model in delivering HF services in the outpatient setting during COVID-19.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13368","type":"journal-article","created":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T04:11:24Z","timestamp":1628741484000},"page":"3906-3916","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Ambulatory Intravenous Furosemide for Decompensated Heart Failure: Safe, Feasible, and Effective"],"prefix":"10.1093","volume":"8","author":[{"given":"Fozia Z.","family":"Ahmed","sequence":"first","affiliation":[{"name":"Manchester Heart Centre, Manchester Royal Infirmary, Manchester University NHS Foundation Trust , Oxford Road, Manchester ,","place":["UK"]},{"name":"Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester , Manchester ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne K.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Manchester Heart Centre, Manchester Royal Infirmary, Manchester University NHS Foundation Trust , Oxford Road, Manchester ,","place":["UK"]},{"name":"Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester , Manchester ,","place":["UK"]},{"name":"Division of Informatics, Imaging and Data Sciences, University of Manchester , Manchester ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anju V.","family":"John","sequence":"additional","affiliation":[{"name":"Manchester Heart Centre, Manchester Royal Infirmary, Manchester University NHS Foundation Trust , Oxford Road, Manchester ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad A.","family":"Khan","sequence":"additional","affiliation":[{"name":"Manchester Heart Centre, Manchester Royal Infirmary, Manchester University NHS Foundation Trust , Oxford Road, Manchester ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir M.","family":"Zaidi","sequence":"additional","affiliation":[{"name":"Manchester Heart Centre, Manchester Royal Infirmary, Manchester University NHS Foundation Trust , Oxford Road, Manchester ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamas A.","family":"Mamas","sequence":"additional","affiliation":[{"name":"Keele Cardiovascular Research Group, Centre for Prognosis Research, Institute for Primary Care and Health Sciences, Keele University , Stoke-on-Trent ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Motwani","sequence":"additional","affiliation":[{"name":"Manchester Heart Centre, Manchester Royal Infirmary, Manchester 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