{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:37:04Z","timestamp":1791247024867,"version":"4.1.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":1654,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T00:00:00Z","timestamp":1623283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004504","name":"Lietuvos Mokslo Taryba","doi-asserted-by":"publisher","award":["MIP-049\/2015"],"award-info":[{"award-number":["MIP-049\/2015"]}],"id":[{"id":"10.13039\/501100004504","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004504","name":"Lietuvos Mokslo Taryba","doi-asserted-by":"publisher","award":["MIP\u2010049\/2015"],"award-info":[{"award-number":["MIP\u2010049\/2015"]}],"id":[{"id":"10.13039\/501100004504","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Readmission and mortality are the most common and often combined endpoints in acute heart failure (AHF) trials, but an association between these two outcomes is poorly investigated. The aim of this study was to determine whether unplanned readmission is associated with a greater subsequent risk of death in patients with acute dyspnoea due to cardiac and non-cardiac causes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Derivation cohort (1371 patients from the LEDA study) and validation cohort (1986 patients from the BASEL V study) included acute dyspnoea patients admitted to the emergency department. Cox regression analysis was used to determine the association of 6 month readmission and the risk of 1 year all-cause mortality in AHF and non-AHF patients and those readmitted due to cardiovascular and non-cardiovascular causes. In the derivation cohort, 666 (49%) of patients were readmitted at 6 months and 282 (21%) died within 1 year. Six month readmission was associated with an increased 1 year mortality risk in both the derivation cohort [adjusted hazard ratio (aHR) 3.0 (95% confidence interval, CI 2.2\u20134.0), P &amp;lt; 0.001] and the validation cohort (aHR 1.8, 95% CI 1.4\u20132.2, P &amp;lt; 0.001). The significant association was similarly observed in AHF (aHR 3.2, 95% CI 2.1\u20134.9, P &amp;lt; 0.001) and other causes of acute dyspnoea (aHR 2.9, 95% CI 1.9\u20134.5, P &amp;lt; 0.001), and it did not depend on the aetiology [aHR 2.2, 95% CI 1.6\u20133.1 for cardiovascular readmissions; aHR 4.1, 95% CI 2.9\u20135.7 for non-cardiovascular readmissions (P &amp;lt; 0.001 for both)] or timing of readmission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion\u200bs<\/jats:title>\n                    <jats:p>Our study demonstrated a long-lasting detrimental association between readmission and death in AHF and non-AHF patients with acute dyspnoea. These patients should be considered \u2018vulnerable patients\u2019 that require personalized follow-up for an extended period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13369","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T19:07:33Z","timestamp":1623352053000},"page":"2473-2484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Readmission Following Both Cardiac and Non-Cardiac Acute Dyspnoea is Associated with a Striking Risk of Death"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6753-9356","authenticated-orcid":false,"given":"Kamil\u0117","family":"\u010cerlinskait\u0117","sequence":"first","affiliation":[{"name":"Clinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University , Vilnius ,","place":["Lithuania"]},{"name":"Inserm UMR-S 942, Cardiovascular Markers in Stress Conditions (MASCOT) , Paris ,","place":["France"]},{"name":"Department of Anesthesiology and Critical Care, H\u00f4pitaux Universitaires Saint Louis-Lariboisi\u00e8re, Assistance Publique des Hopitaux de Paris , 2 Rue Ambroise Par\u00e9, Paris, 75010 ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Mebazaa","sequence":"additional","affiliation":[{"name":"Inserm UMR-S 942, Cardiovascular Markers in Stress Conditions (MASCOT) , Paris ,","place":["France"]},{"name":"Department of Anesthesiology and Critical Care, H\u00f4pitaux Universitaires Saint Louis-Lariboisi\u00e8re, Assistance Publique des Hopitaux de Paris , 2 Rue Ambroise Par\u00e9, Paris, 75010 ,","place":["France"]},{"name":"Universit\u00e9 de Paris , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Cinotti","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Critical Care, 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