{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:04:41Z","timestamp":1790777081438,"version":"4.1.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":1646,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T00:00:00Z","timestamp":1623974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly being used in circulatory failure. The main indications are cardiogenic shock, post-cardiotomy cardiac failure, and refractory cardiac arrest. However, VA-ECMO weaning is particularly challenging, and weaning failure is reported to be as high as 50%, with increased related mortality. Levosimendan is a novel long acting effect inodilator used in cardiogenic shock and terminal heart failure decompensation. Levosimendan use in VA-ECMO patients seems to reduce weaning failure regardless of the initial aetiology and to reduce mortality when administrated early after VA-ECMO initiation. However, studies are limited to retrospective analyses and reported case series. The aim of the WEANILEVO trial is to evaluate whether administration of levosimendan before VA-ECMO weaning is associated with a reduced rates of weaning failure and recourse to other temporary circulatory support.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>WEANILEVO is a randomized, prospective, multicentre, double-blind, parallel-group, controlled trial. One hundred eighty patients will be enrolled if they had acute circulatory heart failure treated with VA-ECMO and for whom weaning is expected within 48 h. The study drugs are either levosimendan (0.2 \u03bcg\/kg\/min for 24 h) or a placebo. The primary endpoint of the trial is the absence of VA-ECMO weaning, recourse to another VA-ECMO, or other temporary circulatory assistance or death within 7 days of VA-ECMO weaning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Levosimendan use in VA-ECMO appears to be beneficial for reducing weaning failure and mortality. The results of WEANILEVO should significantly influence decisions regarding the use of levosimendan for VA-ECMO weaning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13427","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T06:43:03Z","timestamp":1623998583000},"page":"3339-3347","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Levosimendan in Venoarterial ECMO Weaning. Rational and Design of a Randomized Double Blind Multicentre Trial"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8003-5697","authenticated-orcid":false,"given":"Omar","family":"Ellouze","sequence":"first","affiliation":[{"name":"Department of Anesthesia and Critical Care, University Hospital of Dijon , Dijon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Soudry Faure","sequence":"additional","affiliation":[{"name":"Direction of Clinical Research, University Hospital of Dijon , Dijon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Radhouani","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Critical Care, University Hospital of Dijon , Dijon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama","family":"Abou-Arab","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Critical Care, University Hospital of Amiens , Amiens ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Besnier","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Critical Care, University Hospital of Rouen , Rouen ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouhamed","family":"Moussa","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Critical Care, University Hospital of Lille , Lille ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Cransac","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University Hospital of Dijon , Dijon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elea","family":"Ksiazek","sequence":"additional","affiliation":[{"name":"Direction of Clinical Research, University Hospital of Dijon , Dijon ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc-Olivier","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Critical Care, University Hospital of Caen , Caen ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Michel","family":"Mertes","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Critical Care, University Hospital of Strasbourg , Strasbourg ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belaid","family":"Bouhemad","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Critical Care, University Hospital of Dijon , Dijon 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