{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:19:10Z","timestamp":1785449950536,"version":"3.56.0"},"reference-count":87,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":1676,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T00:00:00Z","timestamp":1621382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81173451"],"award-info":[{"award-number":["81173451"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873267"],"award-info":[{"award-number":["81873267"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81173451"],"award-info":[{"award-number":["81173451"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873267"],"award-info":[{"award-number":["81873267"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hyperglycaemia is a major aetiological factor in the development of diabetic cardiomyopathy. Excessive hyperglycaemia increases the levels of reactive carbonyl species (RCS), reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the heart and causes derangements in calcium homeostasis, inflammation and immune-system disorders. Ryanodine receptor 2 (RyR2) plays a key role in excitation\u2013contraction coupling during heart contractions, including rhythmic contraction and relaxation of the heart. Cardiac inflammation has been indicated in part though interleukin 1 (IL-1) signals, supporting a role for B and T lymphocytes in diabetic cardiomyopathy. Some of the post-translational modifications of the ryanodine receptor (RyR) by RCS, ROS and RNS stress are known to affect its gating and Ca2+ sensitivity, which contributes to RyR dysregulation in diabetic cardiomyopathy. RyRs and immune-related molecules are important signalling species in many physiological and pathophysiological processes in various heart and cardiovascular diseases. However, little is known regarding the mechanistic relationship between RyRs and immune-related molecules in diabetes, as well as the mechanisms mediating complex communication among cardiomyocytes, fibroblasts and immune cells. This review highlights new findings on the complex cellular communications in the pathogenesis and progression of diabetic cardiomyopathy. We discuss potential therapeutic applications targeting RyRs and immune-related molecules in diabetic complications.<\/jats:p>","DOI":"10.1002\/ehf2.13431","type":"journal-article","created":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T20:04:35Z","timestamp":1621454675000},"page":"2637-2646","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Ryanodine Receptor and Immune-Related Molecules in Diabetic Cardiomyopathy"],"prefix":"10.1093","volume":"8","author":[{"given":"Cheng-Ju","family":"Tian","sequence":"first","affiliation":[{"name":"College of Rehabilitation and Sports Medicine, Jinzhou Medical University , Jinzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tianjin Anding Hospital , Tianjin ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Guang'anmen Hospital, China Academy of Chinese Medical Sciences , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuang","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Rehabilitation and Sports Medicine, Jinzhou Medical University , Jinzhou ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong","family":"Zhen","sequence":"additional","affiliation":[{"name":"Guang'anmen Hospital, China Academy of Chinese Medical Sciences , Beijing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,5,19]]},"reference":[{"key":"2026012114213984500_ehf213431-bib-0001","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17122136","article-title":"Diabetic cardiomyopathy: does the type of diabetes matter?","volume":"17","author":"Holscher","year":"2016","journal-title":"Int J Mol Sci"},{"key":"2026012114213984500_ehf213431-bib-0002","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/nrendo.2015.216","article-title":"Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy","volume":"12","author":"Jia","year":"2016","journal-title":"Nat Rev Endocrinol"},{"key":"2026012114213984500_ehf213431-bib-0003","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1161\/CIRCRESAHA.118.311371","article-title":"Heart failure in type 2 diabetes mellitus impact of glucose-lowering agents, heart failure therapies, and novel therapeutic strategies","volume":"124","author":"Kenny","year":"2019","journal-title":"Circ Res"},{"key":"2026012114213984500_ehf213431-bib-0004","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.diabres.2019.01.002","article-title":"Methylglyoxal, a potent inducer of AGEs, connects between diabetes and cancer","volume":"148","author":"Bellier","year":"2019","journal-title":"Diabetes Res Clin Pract"},{"key":"2026012114213984500_ehf213431-bib-0005","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2019.00487","article-title":"Detoxification of reactive carbonyl species by glutathione transferase tau isozymes","volume":"10","author":"Mano","year":"2019","journal-title":"Front Plant Sci"},{"key":"2026012114213984500_ehf213431-bib-0006","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2018.01775","article-title":"Redox dependent modifications of ryanodine receptor: basic mechanisms and implications in heart diseases","volume":"9","author":"Nikolaienko","year":"2018","journal-title":"Front Physiol"},{"key":"2026012114213984500_ehf213431-bib-0007","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1161\/CIRCRESAHA.117.310230","article-title":"Calcium and excitation-contraction coupling in the heart","volume":"121","author":"Eisner","year":"2017","journal-title":"Circ Res"},{"key":"2026012114213984500_ehf213431-bib-0008","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1161\/CIRCRESAHA.117.311589","article-title":"Physiologic, pathologic, and therapeutic paracrine modulation of cardiac excitation-contraction coupling","volume":"122","author":"Mayourian","year":"2018","journal-title":"Circ Res"},{"key":"2026012114213984500_ehf213431-bib-0009","doi-asserted-by":"crossref","first-page":"H1105","DOI":"10.1152\/ajpheart.00855.2016","article-title":"Impact of RyR2 potentiation on myocardial function","volume":"312","author":"Lascano","year":"2017","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026012114213984500_ehf213431-bib-0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbamem.2005.09.016","article-title":"Type 1 ryanodine receptor in cardiac mitochondria: transducer of excitation\u2013metabolism coupling","volume":"1717","author":"Beutner","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"2026012114213984500_ehf213431-bib-0011","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1124\/mol.112.078352","article-title":"Carbonylation induces heterogeneity in cardiac ryanodine receptor function in diabetes mellitus","volume":"82","author":"Shao","year":"2012","journal-title":"Mol Pharmacol"},{"key":"2026012114213984500_ehf213431-bib-0012","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.tem.2019.05.005","article-title":"Reactive carbonyl species: diabetic complication in the heart and lungs","volume":"30","author":"Tian","year":"2019","journal-title":"Trends Endocrinol Metab"},{"key":"2026012114213984500_ehf213431-bib-0013","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1002\/ejhf.942","article-title":"Immune mechanisms in heart failure","volume":"19","author":"Zhang","year":"2017","journal-title":"Eur J Heart Fail"},{"key":"2026012114213984500_ehf213431-bib-0014","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20133299","article-title":"Cardiomyopathy associated with diabetes: the central role of the cardiomyocyte","volume":"20","author":"Filardi","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2026012114213984500_ehf213431-bib-0015","doi-asserted-by":"crossref","DOI":"10.1007\/s11892-018-1066-5","article-title":"Immune mechanisms and pathways targeted in type 1 diabetes","volume":"18","author":"Jacobsen","year":"2018","journal-title":"Curr Diab Rep"},{"key":"2026012114213984500_ehf213431-bib-0016","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1136\/postgradmedj-2015-133281","article-title":"Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective","volume":"92","author":"Zaccardi","year":"2016","journal-title":"Postgrad Med J"},{"key":"2026012114213984500_ehf213431-bib-0017","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.coi.2018.10.005","article-title":"Innate immune priming of insulin secretion","volume":"56","author":"Dalmas","year":"2019","journal-title":"Curr Opin Immunol"},{"key":"2026012114213984500_ehf213431-bib-0018","doi-asserted-by":"crossref","DOI":"10.1007\/s11892-014-0543-8","article-title":"Role of B lymphocytes in the pathogenesis of type 1 diabetes","volume":"14","author":"Hinman","year":"2014","journal-title":"Curr Diab Rep"},{"key":"2026012114213984500_ehf213431-bib-0019","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/j.cell.2019.05.007","article-title":"A public BCR present in a unique dual-receptor-expressing lymphocyte from type 1 diabetes patients encodes a potent T cell autoantigen","volume":"177","author":"Ahmed","year":"2019","journal-title":"Cell"},{"key":"2026012114213984500_ehf213431-bib-0020","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/ni.3466","article-title":"Immunometabolism of regulatory T cells","volume":"17","author":"Newton","year":"2016","journal-title":"Nat Immunol"},{"key":"2026012114213984500_ehf213431-bib-0021","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.celrep.2014.09.004","article-title":"An MHC II-dependent activation loop between adipose tissue macrophages and CD4+ T cells controls obesity-induced inflammation","volume":"9","author":"Cho","year":"2014","journal-title":"Cell Rep"},{"key":"2026012114213984500_ehf213431-bib-0022","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/cei.12672","article-title":"CD4 T cell differentiation in type 1 diabetes","volume":"183","author":"Walker","year":"2016","journal-title":"Clin Exp Immunol"},{"key":"2026012114213984500_ehf213431-bib-0023","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/s41577-019-0213-9","article-title":"Targeting innate immune mediators in type 1 and type 2 diabetes","volume":"19","author":"Donath","year":"2019","journal-title":"Nat Rev Immunol"},{"key":"2026012114213984500_ehf213431-bib-0024","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.clim.2018.01.003","article-title":"Human CD4+ CD25+ CD127hi cells and the Th1\/Th2 phenotype","volume":"188","author":"Narsale","year":"2018","journal-title":"Clin Immunol"},{"key":"2026012114213984500_ehf213431-bib-0025","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1161\/CIRCRESAHA.117.311071","article-title":"Resident and monocyte-derived macrophages in cardiovascular disease","volume":"122","author":"Honold","year":"2018","journal-title":"Circ Res"},{"key":"2026012114213984500_ehf213431-bib-0026","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.it.2015.11.004","article-title":"Development and Function of Arterial and Cardiac Macrophages","volume":"37","author":"Swirski","year":"2016","journal-title":"Trends Immunol"},{"key":"2026012114213984500_ehf213431-bib-0027","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/s41577-018-0065-8","article-title":"Cardioimmunology: the immune system in cardiac homeostasis and disease","volume":"18","author":"Swirski","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"2026012114213984500_ehf213431-bib-0028","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1161\/CIRCRESAHA.118.314028","article-title":"Tissue resident CCR2- and CCR2+ cardiac macrophages differentially orchestrate monocyte recruitment and fate specification following myocardial injury","volume":"124","author":"Bajpai","year":"2019","journal-title":"Circ Res"},{"key":"2026012114213984500_ehf213431-bib-0029","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41590-018-0272-2","article-title":"Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction","volume":"20","author":"Dick","year":"2019","journal-title":"Nat Immunol"},{"key":"2026012114213984500_ehf213431-bib-0030","article-title":"Tim-4 in health and disease: friend or foe?","volume":"11","author":"Liu","year":"2020","journal-title":"Front Immunol"},{"key":"2026012114213984500_ehf213431-bib-0031","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1161\/CIRCULATIONAHA.119.045401","article-title":"Transcriptional and cellular diversity of the human heart","volume":"142","author":"Tucker","year":"2020","journal-title":"Circulation"},{"key":"2026012114213984500_ehf213431-bib-0032","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev-immunol-020711-074950","article-title":"The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting","volume":"31","author":"Merad","year":"2013","journal-title":"Annu Rev Immunol"},{"key":"2026012114213984500_ehf213431-bib-0033","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2018.01547","article-title":"The role of leukocytes in diabetic cardiomyopathy","volume":"9","author":"Bajpai","year":"2018","journal-title":"Front Physiol"},{"key":"2026012114213984500_ehf213431-bib-0034","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1161\/CIRCULATIONAHA.114.008788","article-title":"Immune cell and other non-cardiomyocyte regulation of cardiac hypertrophy and remodeling","volume":"131","author":"Frieler","year":"2015","journal-title":"Circulation"},{"key":"2026012114213984500_ehf213431-bib-0035","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1080\/13813455.2017.1401642","article-title":"Reduced soluble toll-like receptors 2 in type 2 diabetes","volume":"124","author":"Zaharieva","journal-title":"Arch Physiol Biochem"},{"key":"2026012114213984500_ehf213431-bib-0036","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1002\/embr.201337945","article-title":"Toll-like receptor 9 protects non-immune cells from stress by modulating mitochondrial ATP synthesis through the inhibition of SERCA2","volume":"15","author":"Shintani","year":"2014","journal-title":"EMBO Rep"},{"key":"2026012114213984500_ehf213431-bib-0037","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41569-019-0315-x","article-title":"Reappraising the role of inflammation in heart failure","volume":"17","author":"Adamo","year":"2020","journal-title":"Nat Rev Cardiol"},{"key":"2026012114213984500_ehf213431-bib-0038","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.jacbts.2019.02.006","article-title":"Fibroblasts in the infarcted, remodeling, and failing heart","volume":"4","author":"Humeres","year":"2019","journal-title":"JACC Basic Transl Sci"},{"key":"2026012114213984500_ehf213431-bib-0039","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/4396368","article-title":"The CXCL10\/CXCR3 axis and cardiac inflammation: implications for immunotherapy to treat infectious and noninfectious diseases of the heart","volume":"2016","author":"Altara","year":"2016","journal-title":"J Immunol Res"},{"key":"2026012114213984500_ehf213431-bib-0040","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1161\/ATVBAHA.118.312037","article-title":"Chemokines as therapeutic targets in cardiovascular disease","volume":"39","author":"Noels","year":"2019","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026012114213984500_ehf213431-bib-0041","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1085\/jgp.201711878","article-title":"The structural basis of ryanodine receptor ion channel function","volume":"149","author":"Meissner","year":"2017","journal-title":"J Gen Physiol"},{"key":"2026012114213984500_ehf213431-bib-0042","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41586-019-1377-y","article-title":"Modulation of cardiac ryanodine receptor 2 by calmodulin","volume":"572","author":"Gong","year":"2019","journal-title":"Nature"},{"key":"2026012114213984500_ehf213431-bib-0043","doi-asserted-by":"crossref","DOI":"10.1126\/science.aah5324","article-title":"Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2","volume":"354","author":"Peng","year":"2016","journal-title":"Science"},{"key":"2026012114213984500_ehf213431-bib-0044","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature14063","article-title":"Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution","volume":"517","author":"Yan","year":"2015","journal-title":"Nature"},{"key":"2026012114213984500_ehf213431-bib-0045","doi-asserted-by":"crossref","first-page":"25575","DOI":"10.1073\/pnas.1914451116","article-title":"Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators","volume":"116","author":"Chi","year":"2019","journal-title":"Proc Natl Acad Sci"},{"key":"2026012114213984500_ehf213431-bib-0046","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cell.2016.08.075","article-title":"Structural basis for gating and activation of RyR1","volume":"167","author":"Georges","year":"2016","journal-title":"Cell"},{"key":"2026012114213984500_ehf213431-bib-0047","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1038\/cr.2016.89","article-title":"The central domain of RyR1 is the transducer for long-range allosteric gating of channel opening","volume":"26","author":"Bai","year":"2016","journal-title":"Cell Res"},{"key":"2026012114213984500_ehf213431-bib-0048","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s10741-013-9384-9","article-title":"Reactive carbonyl species and their roles in sarcoplasmic reticulum Ca2+ cycling defect in the diabetic heart","volume":"19","author":"Tian","year":"2014","journal-title":"Heart Fail Rev"},{"key":"2026012114213984500_ehf213431-bib-0049","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1161\/CIRCRESAHA.117.310083","article-title":"Calcium signaling and cardiac arrhythmias","volume":"120","author":"Landstrom","year":"2017","journal-title":"Circ Res"},{"key":"2026012114213984500_ehf213431-bib-0050","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0092-8674(00)80847-8","article-title":"PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts","volume":"101","author":"Marx","year":"2000","journal-title":"Cell"},{"key":"2026012114213984500_ehf213431-bib-0051","doi-asserted-by":"crossref","first-page":"29250","DOI":"10.1074\/jbc.M115.681767","article-title":"cAMP-dependent protein kinase (PKA) signaling is impaired in the diabetic heart","volume":"290","author":"Bockus","year":"2015","journal-title":"J Biol Chem"},{"key":"2026012114213984500_ehf213431-bib-0052","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1085\/jgp.201311157","article-title":"Differences in the regulation of RyR2 from human, sheep, and rat by Ca2+ and Mg2+ in the cytoplasm and in the lumen of the sarcoplasmic reticulum","volume":"144","author":"Walweel","year":"2014","journal-title":"J Gen Physiol"},{"key":"2026012114213984500_ehf213431-bib-0053","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1161\/CIRCULATIONAHA.117.032703","article-title":"Ryanodine receptor calcium leak in circulating B-lymphocytes as a biomarker in heart failure","volume":"138","author":"Kushnir","year":"2018","journal-title":"Circulation"},{"key":"2026012114213984500_ehf213431-bib-0054","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1161\/CIRCRESAHA.119.315017","article-title":"Acetylation of SERCA2a, another target for heart failure treatment?","volume":"124","author":"Chen","year":"2019","journal-title":"Circ Res"},{"key":"2026012114213984500_ehf213431-bib-0055","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nrcardio.2012.145","article-title":"Altered sarcoplasmic reticulum calcium cycling-targets for heart failure therapy","volume":"9","author":"Kho","year":"2012","journal-title":"Nat Rev Cardiol"},{"key":"2026012114213984500_ehf213431-bib-0056","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/BF00235394","article-title":"Cytoplasmic Ca2+ inhibits the ryanodine receptor from cardiac muscle","volume":"147","author":"Laver","year":"1995","journal-title":"J Membr Biol"},{"key":"2026012114213984500_ehf213431-bib-0057","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.yjmcc.2019.03.018","article-title":"Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814","volume":"130","author":"Walweel","year":"2019","journal-title":"J Mol Cell Cardiol"},{"key":"2026012114213984500_ehf213431-bib-0058","doi-asserted-by":"crossref","first-page":"11389","DOI":"10.1073\/pnas.1513047112","article-title":"Mitochondrial calcium overload is a key determinant in heart failure","volume":"112","author":"Santulli","year":"2015","journal-title":"Proc Natl Acad Sci"},{"key":"2026012114213984500_ehf213431-bib-0059","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1161\/CIRCULATIONAHA.107.711606","article-title":"Expanding spectrum of human RyR2-related disease new electrocardiographic, structural, and genetic features","volume":"116","author":"Bhuiyan","year":"2007","journal-title":"Circulation"},{"key":"2026012114213984500_ehf213431-bib-0060","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s00414-019-02160-8","article-title":"A de novo ryanodine receptor 2 gene variant in a case of sudden cardiac death","volume":"134","author":"Foti","year":"2020","journal-title":"Int J Leg Med"},{"key":"2026012114213984500_ehf213431-bib-0061","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1001\/jamacardio.2019.5400","article-title":"Identification of a novel homozygous multi-exon duplication in RYR2 among children with exertion-related unexplained sudden deaths in the Amish community","volume":"5","author":"Tester","year":"2020","journal-title":"JAMA Cardiol"},{"key":"2026012114213984500_ehf213431-bib-0062","article-title":"Cellular death, reactive oxygen species (ROS) and diabetic complications","volume":"9","author":"Oliveira Volpe","year":"2018","journal-title":"Cell Death Dis"},{"key":"2026012114213984500_ehf213431-bib-0063","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.yjmcc.2005.08.010","article-title":"Tachycardia increases NADPH oxidase activity and RyR2 S-glutathionylation in ventricular muscle","volume":"39","author":"Sanchez","year":"2005","journal-title":"J Mol Cell Cardiol"},{"key":"2026012114213984500_ehf213431-bib-0064","first-page":"41","article-title":"Study of non-muscle cells of the adult mammalian heart: a fine structural analysis and distribution","volume":"28","author":"Nag","year":"1980","journal-title":"Cytobios"},{"key":"2026012114213984500_ehf213431-bib-0065","first-page":"17","article-title":"Development and proliferative capacity of cardiac muscle cells","volume":"32","author":"Zak","year":"1974","journal-title":"Circ Res"},{"key":"2026012114213984500_ehf213431-bib-0066","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1161\/CIRCRESAHA.119.311148","article-title":"The extracellular matrix in ischemic and nonischemic heart failure","volume":"125","author":"Frangogiannis","year":"2019","journal-title":"Circ Res"},{"key":"2026012114213984500_ehf213431-bib-0067","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s40119-018-0104-3","article-title":"A review of interleukin-1 in heart disease: where do we stand today?","volume":"7","author":"Szekely","year":"2018","journal-title":"Cardiol Ther"},{"key":"2026012114213984500_ehf213431-bib-0068","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1161\/CIRCULATIONAHA.106.643585","article-title":"Tumor necrosis factor-\u03b1 mediates cardiac remodeling and ventricular dysfunction after pressure overload state","volume":"115","author":"Sun","year":"2007","journal-title":"Circulation"},{"key":"2026012114213984500_ehf213431-bib-0069","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1161\/CIRCRESAHA.116.302317","article-title":"Innate immunity and the failing heart: the cytokine hypothesis revisited","volume":"116","author":"Mann","year":"2015","journal-title":"Circ Res"},{"key":"2026012114213984500_ehf213431-bib-0070","doi-asserted-by":"crossref","DOI":"10.1007\/s11886-018-1067-7","article-title":"Tumor necrosis factor-\u03b1 in heart failure: an updated review","volume":"20","author":"Schumacher","year":"2018","journal-title":"Curr Cardiol Rep"},{"key":"2026012114213984500_ehf213431-bib-0071","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cardiores.2007.06.003","article-title":"Mechanism of TNF alpha-induced IL-1alpha, IL-1beta and IL-6 expression in human cardiac fibroblasts: effects of statins and thiazolidinediones","volume":"76","author":"Turner","year":"2007","journal-title":"Cardiovasc Res"},{"key":"2026012114213984500_ehf213431-bib-0072","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1161\/CIRCRESAHA.109.209809","article-title":"Cardiac fibroblast: the renaissance cell","volume":"105","author":"Souders","year":"2009","journal-title":"Circ Res"},{"key":"2026012114213984500_ehf213431-bib-0073","article-title":"Ca2+ signaling in cardiac fibroblasts and fibrosis-associated heart diseases","volume":"6","author":"Feng","year":"2019","journal-title":"J Cardiovasc Dev Dis"},{"key":"2026012114213984500_ehf213431-bib-0074","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/jcp.22010","article-title":"Multiple Ca2+ signaling pathways regulate intracellular Ca2+ activity in human cardiac fibroblasts","volume":"223","author":"Chen","year":"2010","journal-title":"J Cell Physiol"},{"key":"2026012114213984500_ehf213431-bib-0075","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1536\/ihj.16-572","article-title":"Ryanodine receptor type 2 plays a role in the development of cardiac fibrosis under mechanical stretch through TGF\u03b2-1","volume":"58","author":"Ding","year":"2017","journal-title":"Int Heart J"},{"key":"2026012114213984500_ehf213431-bib-0076","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.yjmcc.2016.03.005","article-title":"Myocyte-fibroblast communication in cardiac fibrosis and arrhythmias: mechanisms and model systems","volume":"94","author":"Pellman","year":"2016","journal-title":"J Mol Cell Cardiol"},{"key":"2026012114213984500_ehf213431-bib-0077","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1093\/cvr\/cvu264","article-title":"Functional crosstalk between cardiac fibroblasts and adult cardiomyocytes by soluble mediators","volume":"105","author":"Cartledge","year":"2015","journal-title":"Cardiovasc Res"},{"key":"2026012114213984500_ehf213431-bib-0078","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.019338","article-title":"Complex relationship between cardiac fibroblasts and cardiomyocytes in health and disease","volume":"10","author":"Hall","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"2026012114213984500_ehf213431-bib-0079","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.010595","article-title":"Emerging arrhythmic risk of autoimmune and inflammatory cardiac channelopathies","volume":"7","author":"Lazzerini","year":"2018","journal-title":"J Am Heart Assoc"},{"key":"2026012114213984500_ehf213431-bib-0080","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.ceca.2010.02.002","article-title":"TNF-\u03b1 and IL-1\u03b2 increase Ca2+ leak from the sarcoplasmic reticulum and susceptibility to arrhythmia in rat ventricular myocytes","volume":"47","author":"Duncan","year":"2010","journal-title":"Cell Calcium"},{"key":"2026012114213984500_ehf213431-bib-0081","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1242\/jcs.007203","article-title":"Ca2+ signaling through ryanodine receptor 1 enhances maturation and activation of human dendritic cells","volume":"120","author":"Bracci","year":"2007","journal-title":"J Cell Sci"},{"key":"2026012114213984500_ehf213431-bib-0082","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.bbrc.2007.08.024","article-title":"Identification of functional type 1 ryanodine receptors in human dendritic cells","volume":"362","author":"Uemura","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"2026012114213984500_ehf213431-bib-0083","doi-asserted-by":"crossref","first-page":"48077","DOI":"10.1074\/jbc.M107134200","article-title":"B-lymphocytes from malignant hyperthermia-susceptible patients have an increased sensitivity to skeletal muscle ryanodine receptor activators","volume":"276","author":"Girard","year":"2001","journal-title":"J Biol Chem"},{"key":"2026012114213984500_ehf213431-bib-0084","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/2164017","article-title":"Role of inflammatory cell subtypes in heart failure","volume":"2019","author":"Strassheim","year":"2019","journal-title":"J Immunol Res"},{"key":"2026012114213984500_ehf213431-bib-0085","doi-asserted-by":"crossref","first-page":"37233","DOI":"10.1074\/jbc.M112.398974","article-title":"Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes","volume":"287","author":"Thakur","year":"2012","journal-title":"J Biol Chem"},{"key":"2026012114213984500_ehf213431-bib-0086","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/s41577-018-0110-7","article-title":"Calcium signalling in T cells","volume":"19","author":"Trebak","year":"2019","journal-title":"Nat Rev Immunol"},{"key":"2026012114213984500_ehf213431-bib-0087","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aat0358","article-title":"ORAI1, STIM1\/2, and RYR1 shape subsecond Ca 2+ microdomains upon T cell activation","volume":"11","author":"Diercks","year":"2018","journal-title":"Sci Signal"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ehf2.13431","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ehf2.13431","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/8\/4\/2637\/65569392\/eschf_8_4_2637.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/8\/4\/2637\/65569392\/eschf_8_4_2637.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T19:26:44Z","timestamp":1769023604000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/8\/4\/2637\/8344463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,19]]},"references-count":87,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,5,19]]},"published-print":{"date-parts":[[2021,8,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ehf2.13431","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,8]]},"published":{"date-parts":[[2021,5,19]]},"assertion":[{"value":"2021-01-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}