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Jorck og Hustrus Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006426","name":"Eva og Henry Fr\u00e6nkels Mindefond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006426","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Despite adequate treatment, recent studies have hypothesized that malaria may affect long-term cardiovascular function. We aimed to investigate the long-term risk of cardiovascular events and death in individuals with a history of imported malaria in Denmark.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using nationwide Danish registries, we followed individuals with a history of malaria for the risk of incident heart failure (HF), myocardial infarction (MI), cardiovascular death and all-cause death (1 January 1994 to 1 January 2017). The population was age- and sex-matched with individuals without a history of malaria from the Danish population (ratio 1:9). We excluded patients with known HF and ischaemic heart disease at inclusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 3912 cases with a history of malaria (mean age 33 \u00b1 17 years, 57% male, 41% Plasmodium falciparum infections). The median follow-up was 9.8 years (interquartile range 3.9\u201316.4 years). Event rates per 1000 person-years for individuals with a history vs. no history of malaria were HF: 1.84 vs. 1.32; MI: 1.28 vs. 1.30; cardiovascular death: 1.40 vs. 1.77; and all-cause death: 5.04 vs. 5.28. In Cox proportional hazards models adjusted for cardiovascular risk factors, concomitant pharmacotherapy, region of origin, household income and educational level, malaria was associated with HF (HR: 1.59 [1.21\u20132.09], P = 0.001), but not MI (HR: 1.00 [0.72\u20131.39], P = 1.00), cardiovascular death (HR: 1.00 [0.74\u20131.35], P = 0.98) or all-cause death (HR 1.11 [0.94\u20131.30], P = 0.21). Specifically, P.\u2009falciparum infection was associated with increased risk of HF (HR: 1.64 [1.14\u20132.36], P = 0.008).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Individuals with a history of imported malaria, specifically P.\u2009falciparum, may have an increased risk of incident HF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13441","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T03:49:34Z","timestamp":1627357774000},"page":"3521-3529","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Heart Failure Associated with Imported Malaria: A Nationwide Danish Cohort Study"],"prefix":"10.1093","volume":"8","author":[{"given":"Philip","family":"Brainin","sequence":"first","affiliation":[{"name":"Department of Cardiology, Herlev and Gentofte Hospital , Herlev ,","place":["Denmark"]},{"name":"Department of Cardiology, Federal University of Acre, C\u00e2mpus Floresta , Cruzeiro do Sul ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grimur H\u00f8gnason","family":"Mohr","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herlev and Gentofte Hospital , Herlev ,","place":["Denmark"]},{"name":"Centre for Neuropsychiatric Schizophrenia Research, CNSR, Mental Health Centre Glostrup, University of Copenhagen , Glostrup, MA ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Modin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herlev and Gentofte Hospital , Herlev ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Claggett","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School , Boston, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odilson M.","family":"Silvestre","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Federal University of Acre, C\u00e2mpus Floresta , Cruzeiro do Sul ,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amil","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School , Boston, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasse S.","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"National Malaria Reference Laboratory, Department of Bacteria, Parasites and Fungi, Statens Serum Institut , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Ulrik St\u00e6hr","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Respiratory Medicine Section, Copenhagen University , Copenhagen ,","place":["Denmark"]},{"name":"PERSIMUNE, Department of Infectious Diseases, Rigshospitalet, Copenhagen University , Copenhagen ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Hviid","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, Copenhagen University , Copenhagen ,","place":["Denmark"]},{"name":"Department of Infectious Diseases, Rigshospitalet, Copenhagen University , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Torp-Pedersen","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Clinical Research, Nordsjaellands Hospital , Hiller\u00f8d ,","place":["Denmark"]},{"name":"Department of Cardiology, Aalborg University Hospital , Aalborg ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"K\u00f8ber","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Copenhagen , Copenhagen ,","place":["Denmark"]},{"name":"Department of Cardiology, Rigshospitalet, Copenhagen University , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Solomon","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School , Boston, MA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Schou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herlev and Gentofte Hospital , Herlev ,","place":["Denmark"]},{"name":"Department of 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