{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:41:20Z","timestamp":1786977680505,"version":"build-2736575974"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":1664,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T00:00:00Z","timestamp":1622419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Gothenburg Society of Medicine","award":["20\/935037"],"award-info":[{"award-number":["20\/935037"]}]},{"name":"Regional Development Fund, V\u00e4stra G\u00f6taland County, Sweden","award":["VGFOUREG-849081"],"award-info":[{"award-number":["VGFOUREG-849081"]}]},{"name":"Regional Development Fund, V\u00e4stra G\u00f6taland County, Sweden","award":["VGFOUREG-931060"],"award-info":[{"award-number":["VGFOUREG-931060"]}]},{"name":"ALF agreement","award":["ALFGBG-72900,73400"],"award-info":[{"award-number":["ALFGBG-72900,73400"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To study clinical phenotype, prognosis for all-cause and cardiovascular (CV) mortality and predictive factors in patients with incident heart failure (HF) after aortic valvular intervention (AVI) for aortic stenosis (AS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>In this retrospective, observational study we included patients from the Swedish Heart Failure Registry (SwedeHF) recorded 2003\u20132016, with AS diagnosis and AVI before HF diagnosis. The AS diagnosis was established according to International Classification of Diseases 10th revision (ICD-10) codes, thus without information concerning clinical or echocardiographical data on the aortic valve disease. The patients were divided into two subgroups: left ventricular ejection fraction (LVEF) \u2265 50% (AS-HFpEF) and &amp;lt;50% (AS-HFrEF). We individually matched three controls with HF from the SwedeHF without AS (control group) for each patient. Baseline characteristics, co-morbidities, survival status and outcomes were obtained by linking the SwedeHF with two other Swedish registries. We used Kaplan\u2013Meier curves to present time to all-cause mortality, cumulative incidence function for time to CV mortality and Cox proportional hazards model to evaluate the relative difference between AS-HFrEF and AS-HFpEF and AS-HF and controls. The crude all-cause mortality was 49.0%, CV mortality 27.9% in AS-HF patients, respectively 44.7% and 26.6% in matched controls. The adjusted risk for all-cause mortality and CV mortality was similar in HF, regardless of LVEF vs. controls. No significant difference in factors predicting higher all-cause mortality was observed in AS-HFrEF vs. AS-HFpEF, except for diabetes (only in AS-HFrEF), with statistically significant interaction predicting death between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this nationwide SwedeHF study, we characterized incident HF population after AVI. We found no significant differences in all-cause and CV mortality compared with general HF population. They had virtually the same predictors for mortality, regardless of LVEF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13451","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T05:27:24Z","timestamp":1622438844000},"page":"3237-3247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prognosis and Outcome Determinants After Heart Failure Diagnosis in Patients Who Underwent Aortic Valvular Intervention"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3564-8208","authenticated-orcid":false,"given":"Silvana","family":"Kontogeorgos","sequence":"first","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9134-2107","authenticated-orcid":false,"given":"Erik","family":"Thunstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2224-3236","authenticated-orcid":false,"given":"Aldina","family":"Pivodic","sequence":"additional","affiliation":[{"name":"Statistiska Konsultgruppen , Gothenburg ,","place":["Sweden"]},{"name":"Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg , Gothenburg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6353-8041","authenticated-orcid":false,"given":"Ulf","family":"Dahlstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Department of Health, Medicine and Caring Sciences, Linkoping University , Linkoping ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8860-1051","authenticated-orcid":false,"given":"Michael","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,5,31]]},"reference":[{"key":"2026012114203442300_ehf213451-bib-0001","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1093\/eurheartj\/ehw334","article-title":"Cardiovascular disease in Europe: epidemiological update 2016","volume":"37","author":"Townsend","year":"2016","journal-title":"Eur Heart J"},{"key":"2026012114203442300_ehf213451-bib-0002","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1056\/NEJMra1313875","article-title":"Aortic-valve stenosis--from patients at risk to severe valve obstruction","volume":"371","author":"Otto","year":"2014","journal-title":"N Engl J Med"},{"key":"2026012114203442300_ehf213451-bib-0003","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1111\/jocs.14226","article-title":"TAVI and the future of aortic valve replacement","volume":"34","author":"Howard","year":"2019","journal-title":"J Card Surg"},{"key":"2026012114203442300_ehf213451-bib-0004","doi-asserted-by":"crossref","first-page":"99","DOI":"10.15420\/cfr.2018.41.2","article-title":"Aortic stenosis and heart failure: disease ascertainment and statistical considerations for clinical trials","volume":"5","author":"Spitzer","year":"2019","journal-title":"Card Fail Rev"},{"key":"2026012114203442300_ehf213451-bib-0005","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/eurjhf\/hfp175","article-title":"Heart failure registry: a valuable tool for improving the management of patients with heart failure","volume":"12","author":"Jonsson","year":"2010","journal-title":"Eur J Heart Fail"},{"key":"2026012114203442300_ehf213451-bib-0006","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/03009734.2018.1490831","article-title":"The Swedish Heart Failure Registry: a living, ongoing quality assurance and research in heart failure","volume":"124","author":"Savarese","year":"2019","journal-title":"Ups J Med Sci"},{"key":"2026012114203442300_ehf213451-bib-0007","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"key":"2026012114203442300_ehf213451-bib-0008","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2458-11-450","article-title":"External review and validation of the Swedish national inpatient register","volume":"11","author":"Ludvigsson","year":"2011","journal-title":"BMC Public Health"},{"key":"2026012114203442300_ehf213451-bib-0009","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s10654-017-0316-1","article-title":"The Swedish cause of death register","volume":"32","author":"Brooke","year":"2017","journal-title":"Eur J Epidemiol"},{"key":"2026012114203442300_ehf213451-bib-0010","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.jchf.2015.03.004","article-title":"Burden of comorbidities and functional and cognitive impairments in elderly patients at the initial diagnosis of heart failure and their impact on total mortality: the cardiovascular health study","volume":"3","author":"Murad","year":"2015","journal-title":"JACC Heart failure"},{"key":"2026012114203442300_ehf213451-bib-0011","doi-asserted-by":"crossref","DOI":"10.1186\/s12889-019-7934-3","article-title":"Mortality after hospital admission for heart failure: improvement over time, equally strong in women as in men","volume":"20","author":"Buddeke","year":"2020","journal-title":"BMC Public Health"},{"key":"2026012114203442300_ehf213451-bib-0012","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1136\/heartjnl-2016-310894","article-title":"Epidemiology of valvular heart disease in a Swedish nationwide hospital-based register study","volume":"103","author":"Andell","year":"2017","journal-title":"Heart"},{"key":"2026012114203442300_ehf213451-bib-0013","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1136\/heartjnl-2012-302265","article-title":"The evolving epidemiology of valvular aortic stenosis. The Tromso study","volume":"99","author":"Eveborn","year":"2013","journal-title":"Heart"},{"key":"2026012114203442300_ehf213451-bib-0014","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","article-title":"Burden of valvular heart diseases: a population-based study","volume":"368","author":"Nkomo","year":"2006","journal-title":"Lancet"},{"key":"2026012114203442300_ehf213451-bib-0015","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1056\/NEJMoa051530","article-title":"Outcome of heart failure with preserved ejection fraction in a population-based study","volume":"355","author":"Bhatia","year":"2006","journal-title":"N Engl J Med"},{"key":"2026012114203442300_ehf213451-bib-0016","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/ejhf.442","article-title":"Spectrum of epidemiological and clinical findings in patients with heart failure with preserved ejection fraction stratified by study design: a systematic review","volume":"18","author":"Vaduganathan","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"2026012114203442300_ehf213451-bib-0017","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1093\/eurheartj\/ehr254","article-title":"The survival of patients with heart failure with preserved or reduced left ventricular ejection fraction: an individual patient data meta-analysis","volume":"33","year":"2012","journal-title":"Eur Heart J"},{"key":"2026012114203442300_ehf213451-bib-0018","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jacc.2003.07.046","article-title":"Heart failure with preserved left ventricular systolic function; epidemiology, clinical characteristics, and prognosis","volume":"43","author":"Hogg","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"2026012114203442300_ehf213451-bib-0019","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S0195-668X(02)00845-X","article-title":"Long-term survival in patients hospitalized with congestive heart failure: relation to preserved and reduced left ventricular systolic function","volume":"24","author":"Gustafsson","year":"2003","journal-title":"Eur Heart J"},{"key":"2026012114203442300_ehf213451-bib-0020","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1080\/14017431.2019.1685126","article-title":"Prevalence and risk factors of aortic stenosis and aortic sclerosis: a 21-year follow-up of middle-aged men","volume":"54","author":"Kontogeorgos","year":"2020","journal-title":"Scand Cardiovasc J"},{"key":"2026012114203442300_ehf213451-bib-0021","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/eurheartj\/ehm554","article-title":"Prognosis of heart failure with preserved ejection fraction: a 5 year prospective population-based study","volume":"29","author":"Tribouilloy","year":"2008","journal-title":"Eur Heart J"},{"key":"2026012114203442300_ehf213451-bib-0022","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1136\/hrt.2005.062422","article-title":"Impaired coronary and myocardial flow in severe aortic stenosis is associated with increased apoptosis: a transthoracic Doppler and myocardial contrast echocardiography study","volume":"92","author":"Galiuto","year":"2006","journal-title":"Heart"},{"key":"2026012114203442300_ehf213451-bib-0023","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1161\/01.CIR.86.1.38","article-title":"Morphometry of human coronary capillaries during normal growth and the effect of age in left ventricular pressure-overload hypertrophy","volume":"86","author":"Rakusan","year":"1992","journal-title":"Circulation"},{"key":"2026012114203442300_ehf213451-bib-0024","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1161\/01.CIR.0000051865.66123.B7","article-title":"Progression from compensated hypertrophy to failure in the pressure-overloaded human heart: structural deterioration and compensatory mechanisms","volume":"107","author":"Hein","year":"2003","journal-title":"Circulation"},{"key":"2026012114203442300_ehf213451-bib-0025","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1016\/j.jacc.2012.02.093","article-title":"Calcific aortic stenosis: a disease of the valve and the myocardium","volume":"60","author":"Dweck","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"2026012114203442300_ehf213451-bib-0026","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1161\/hc1202.105290","article-title":"New concepts in diastolic dysfunction and diastolic heart failure: part II: causal mechanisms and treatment","volume":"105","author":"Zile","year":"2002","journal-title":"Circulation"},{"key":"2026012114203442300_ehf213451-bib-0027","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1161\/01.CIR.64.1.126","article-title":"Determinants of ejection performance in aortic stenosis","volume":"64","author":"Huber","year":"1981","journal-title":"Circulation"},{"key":"2026012114203442300_ehf213451-bib-0028","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1097\/EJA.0b013e3283657829","article-title":"Long-term absolute and relative survival after aortic valve replacement: a prospective cohort study","volume":"30","author":"Lassnigg","year":"2013","journal-title":"Eur J Anaesthesiol"},{"key":"2026012114203442300_ehf213451-bib-0029","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1016\/j.jtcvs.2018.10.040","article-title":"Bioprosthetic aortic valve replacement in elderly patients: meta-analysis and microsimulation","volume":"157","author":"Huygens","year":"2019","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2026012114203442300_ehf213451-bib-0030","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jacc.2019.04.053","article-title":"Loss in life expectancy after surgical aortic valve replacement: SWEDEHEART study","volume":"74","author":"Glaser","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2026012114203442300_ehf213451-bib-0031","article-title":"Prognosis after surgical replacement with a bioprosthetic aortic valve in patients with severe symptomatic aortic stenosis: systematic review of observational studies","volume":"354","author":"Foroutan","year":"2016","journal-title":"BMJ"},{"key":"2026012114203442300_ehf213451-bib-0032","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1093\/eurheartj\/ehv580","article-title":"Aortic valve replacement with mechanical vs. biological prostheses in patients aged 50-69 years","volume":"37","author":"Glaser","year":"2016","journal-title":"Eur Heart J"},{"key":"2026012114203442300_ehf213451-bib-0033","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1093\/ejcts\/ezu017","article-title":"Trends and outcomes of valve surgery: 16-year results of Netherlands Cardiac Surgery National Database","volume":"46","author":"Siregar","year":"2014","journal-title":"Eur J Cardiothorac Surg"},{"key":"2026012114203442300_ehf213451-bib-0034","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1161\/CIRCULATIONAHA.118.035150","article-title":"Rate, timing, correlates, and outcomes of hemodynamic valve deterioration after bioprosthetic surgical aortic valve replacement","volume":"138","author":"Salaun","year":"2018","journal-title":"Circulation"},{"key":"2026012114203442300_ehf213451-bib-0035","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0002-9149(99)00392-6","article-title":"Comparison of incidences of congestive heart failure in older African-Americans, Hispanics, and whites","volume":"84","author":"Aronow","year":"1999","journal-title":"Am J Cardiol"},{"key":"2026012114203442300_ehf213451-bib-0036","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1111\/dom.13652","article-title":"Heart failure in the patient with diabetes: epidemiology, aetiology, prognosis, therapy and the effect of glucose-lowering medications","volume":"21","author":"Bell","year":"2019","journal-title":"Diabetes Obes Metab"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ehf2.13451","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ehf2.13451","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/8\/4\/3237\/65569929\/eschf_8_4_3237.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/8\/4\/3237\/65569929\/eschf_8_4_3237.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T19:25:03Z","timestamp":1769023503000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/8\/4\/3237\/8344153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,31]]},"references-count":36,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,5,31]]},"published-print":{"date-parts":[[2021,8,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ehf2.13451","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,8]]},"published":{"date-parts":[[2021,5,31]]},"assertion":[{"value":"2020-11-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}