{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T04:08:27Z","timestamp":1774584507409,"version":"3.50.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":1645,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T00:00:00Z","timestamp":1624060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Amyloid transthyretin (ATTR) depositions cause left ventricular (LV) hypertrophy, diastolic dysfunction, and heart failure. The time course of changes in LV geometry and diastolic dysfunction has not been fully reported in patients with ATTR cardiomyopathy. A 79-year-old woman with previous myocardial infraction presented with shortness of breath on exertion, and progressive bilateral lower extremity weakness and polyneuropathy. She was diagnosed with Val30Met hereditary ATTR cardiomyopathy by cardiac biopsy and genetic testing. During the past 5 year period, significant LV concentric remodelling with small LV cavity occurred, resulting in an increased LV stiffness and prolonged LV relaxation. This case report highlights the time course of changes in LV geometry and diastolic function and the importance of early diagnosis of ATTR cardiomyopathy.<\/jats:p>","DOI":"10.1002\/ehf2.13454","type":"journal-article","created":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T04:44:30Z","timestamp":1624077870000},"page":"3422-3426","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Trajectory of Left Ventricular Geometry and Diastolic Dysfunction in Hereditary Transthyretin Cardiac Amyloidosis"],"prefix":"10.1093","volume":"8","author":[{"given":"Tatsuya","family":"Akatsuka","sequence":"first","affiliation":[{"name":"Department of Cardiology and Nephrology, Mie University Graduate School of Medicine , 2-174 Edobashi, Tsu, Mie, 514-8507 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Nephrology, Mie University Graduate School of Medicine , 2-174 Edobashi, Tsu, Mie, 514-8507 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Ishiyama","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Nephrology, Mie University Graduate School of Medicine , 2-174 Edobashi, Tsu, Mie, 514-8507 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Nakamori","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Nephrology, Mie University Graduate School of Medicine , 2-174 Edobashi, Tsu, Mie, 514-8507 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Imanaka-Yoshida","sequence":"additional","affiliation":[{"name":"Department of Pathology and Matrix Biology, Mie University Graduate School of Medicine , Tsu ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Dohi","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Nephrology, Mie University Graduate School of Medicine , 2-174 Edobashi, Tsu, Mie, 514-8507 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,6,19]]},"reference":[{"key":"2026012114203426900_ehf213454-bib-0001","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1152\/ajpheart.01240.2005","article-title":"Single-beat estimation of end-diastolic pressure-volume relationship: a novel method with potential for noninvasive application","volume":"291","author":"Klotz","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026012114203426900_ehf213454-bib-0002","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1161\/CIRCULATIONAHA.106.659763","article-title":"Cardiac structure and ventricular-vascular function in persons with heart failure and preserved ejection fraction from Olmsted County, Minnesota","volume":"115","author":"Lam","year":"2007","journal-title":"Circulation"},{"key":"2026012114203426900_ehf213454-bib-0003","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1161\/01.CIR.0000048123.22359.A0","article-title":"Combined ventricular systolic and arterial stiffening in patients with heart failure and preserved ejection fraction: implications for systolic and diastolic reserve limitations","volume":"107","author":"Kawaguchi","year":"2003","journal-title":"Circulation"},{"key":"2026012114203426900_ehf213454-bib-0004","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1016\/j.jcmg.2020.05.030","article-title":"Myocardial native T1 predicts load-independent left ventricular chamber stiffness in patients with HFpEF","volume":"13","author":"Omori","year":"2020","journal-title":"JACC Cardiovasc Imaging"},{"key":"2026012114203426900_ehf213454-bib-0005","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1161\/01.RES.48.6.813","article-title":"Volume loading slows left ventricular isovolumic relaxation rate. 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