{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:07:18Z","timestamp":1791410838799,"version":"4.3.3"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":1656,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T00:00:00Z","timestamp":1623110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Optimizing medical cardiac treatment for sleep apnoea (SA) in patients with chronic heart failure and reduced ejection fraction (HFrEF) is an expert Grade C recommendation based on six studies encompassing a total of 67 patients only. Whether sacubitril\u2013valsartan (SV), a cornerstone of HFrEF medical treatment, impacts SA is unknown and requires evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>The ENTRESTO-SAS trial is a six-centre, prospective, open-label real-life cohort study (NCT02916160). Ambulatory patients eligible for SV (i.e. HFrEF adults who remain symptomatic despite optimal treatment) were evaluated before and after 3 months of SV (including nocturnal ventilatory polygraphy); 118 patients were final analysed [median age was 66 (IQ25\u201375: 56\u201373) years, 81.4% male, 36.5% New York Heart Association III\u2013IV, N-terminal pro-B-type natriuretic peptide level of 1564 (701\u20133376) ng\/L, left ventricular ejection fraction of 30 (25\u201334)%, 60.7% ischaemic HFrEF, 97.5% initially treated with angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers, 83.9% with beta-blockers, 64.4% with mineralocorticoid receptor antagonists, and 74.6% with diuretics]. Three groups were defined according to initial central\/obstructive apnoea\u2013hypopnoea indices (AHIs): G1 (n = 49, AHIcentral \u2265 5\/h and AHIobstructive &amp;lt; 15\/h); G2 (n = 27, AHIobstructive \u2265 15\/h); and G3 (n = 42, AHIcentral &amp;lt; 5\/h and AHIobstructive &amp;lt; 15\/h). At 3 months, the AHI (main predefined outcome) decreased significantly by \u22127.10\/h (IQ25\u201375: \u221216.10 to 0.40; P &amp;lt; 0.001) in G1 + G2 without positive airway pressure treatment (45 patients, median initial AHI of 24.20 (IQ25\u201375: 16.40\u201343.50)\/h). Of these, 24.4% presented an AHI decrease \u226550% and 37.78% had a final AHI &amp;lt; 15\/h (tendency for improvement from an initial value of 20%: P = 0.0574). For G1 patients (n = 37), AHI significantly decreased from a median of 22.90 (16.00\u201343.50)\/h to 19.20 (12.70\u201331.10)\/h (P = 0.002). For G2 patients (n = 8), AHI decreased from a median of 30.10 (26.40\u201347.60)\/h to 22.75 (14.60\u201336.90)\/h (statistically non-significant, P = 0.059).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this real-life population, SV treatment for 3 months in SA patients is associated with a significant decrease in AHI. These results support the current guidelines that recommend first an optimization of the HFrEF treatment in patients with HFrEF and central SA. A potential positive airway pressure sparing effect merits further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13455","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T05:32:44Z","timestamp":1623216764000},"page":"2513-2526","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Sacubitril-Valsartan Initiation in Chronic Heart Failure Patients Impacts Sleep Apnea: The ENTRESTO-SAS Study"],"prefix":"10.1093","volume":"8","author":[{"given":"Dany","family":"Jaffuel","sequence":"first","affiliation":[{"name":"Department of Pneumology, Arnaud de Villeneuve, Regional University Hospital of Montpellier , Montpellier ,","place":["France"]},{"name":"PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214 , Montpellier 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,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Fournier","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Rangueil , Toulouse ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Dupuis","sequence":"additional","affiliation":[{"name":"Department of Pneumology, Respiratory Tracts Center, H\u00f4pital Larrey , Toulouse ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Georger","sequence":"additional","affiliation":[{"name":"Department of Cardiology, B\u00e9ziers Hospital , B\u00e9ziers ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Pierre","family":"Cadars","sequence":"additional","affiliation":[{"name":"Centre M\u00e9decine du Sommeil et Assistance respiratoire, B\u00e9ziers Hospital , B\u00e9ziers ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Etienne","family":"Ricci","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Caremeau , N\u00eemes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Plouvier","sequence":"additional","affiliation":[{"name":"Department of Pneumology, University Hospital Caremeau , N\u00eemes ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Picard","sequence":"additional","affiliation":[{"name":"Heart Failure Unit, Haut-L\u00e9v\u00eaque Hospital , Pessac ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Puel","sequence":"additional","affiliation":[{"name":"PEAS, Nouvelle Clinique Bel-Air , Bordeaux 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