{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:44:22Z","timestamp":1789778662225,"version":"4.0.1"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":1573,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"ALF-agreement"},{"DOI":"10.13039\/501100003793","name":"Swedish Heart-Lung Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Swedish Scientific Council"},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Takotsubo syndrome (TTS) is an acute potentially reversible cardiac syndrome characterized by variable regional myocardial akinesia that cannot be attributed to a culprit coronary artery occlusion. TTS is an important differential diagnosis of acute heart failure where brain natriuretic peptides are elevated. Sacubitril\/valsartan is a novel and effective pharmacological agent for the treatment of patients with heart failure. Our aim was to explore whether treatment with sacubitril\/valsartan could prevent isoprenaline-induced takotsubo-like phenotype in rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>A total number of 186 Sprague\u2013Dawley male rats were randomized to receive pretreatment with water (CONTROL, n = 62), valsartan (VAL, n = 62), or sacubitril\/valsartan (SAC\/VAL, n = 62) before receiving isoprenaline for induction of TTS. We recorded heart rate and blood pressure invasively. Cardiac morphology and function were evaluated by high-resolution echocardiography 90 min after the administration of isoprenaline. We documented the survival rate at the time of echocardiography. Compared with the CONTROL group, the SAC\/VAL group had less pronounced TTS-like cardiac dysfunction and lower mortality rate, while the VAL group did not differ. Heart rate and blood pressure were not significantly different between the groups. Analysis of cardiac lipids was performed with mass spectrometry. The VAL and SAC\/VAL groups had significantly higher levels of lysophosphatidylcholine (LPC), in particular LPC 18:1 and LPC 16:0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pretreatment with sacubitril\/valsartan but not with valsartan reduces mortality and attenuates isoprenaline-induced apical akinesia in the TTS-like model in rats. Sacubitril\/valsartan could be a potential treatment option in patients with TTS in humans.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13530","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T00:52:03Z","timestamp":1630371123000},"page":"4130-4138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Sacubitril\/Valsartan Decreases Mortality in the Rat Model of the Isoprenaline-Induced Takotsubo-Like Syndrome"],"prefix":"10.1093","volume":"8","author":[{"given":"Anwar","family":"Ali","sequence":"first","affiliation":[{"name":"Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Redfors","sequence":"additional","affiliation":[{"name":"Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Alkhoury","sequence":"additional","affiliation":[{"name":"Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonatan","family":"Oras","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg , Gothenburg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Henricsson","sequence":"additional","affiliation":[{"name":"Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Boren","sequence":"additional","affiliation":[{"name":"Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Bj\u00f6rnson","sequence":"additional","affiliation":[{"name":"Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Espinosa","sequence":"additional","affiliation":[{"name":"Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malin","family":"Levin","sequence":"additional","affiliation":[{"name":"Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ming","family":"Gan","sequence":"additional","affiliation":[{"name":"Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg ,","place":["Sweden"]},{"name":"Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca , Gothenburg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3875-8621","authenticated-orcid":false,"given":"Elmir","family":"Omerovic","sequence":"additional","affiliation":[{"name":"Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg , Gothenburg ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,8,30]]},"reference":[{"key":"2026012114220148900_ehf213530-bib-0001","first-page":"55","article-title":"Clinical aspect of myocardial injury: from ischemia to heart failure","author":"Sato","year":"1990","journal-title":"Kagaku Hyoronsha."},{"key":"2026012114220148900_ehf213530-bib-0002","first-page":"203","article-title":"Myocardial stunning due to simultaneous multivessel coronary spasms: a review of 5 cases","volume":"21","author":"Dote","year":"1991","journal-title":"J Cardiol."},{"key":"2026012114220148900_ehf213530-bib-0003","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1093\/ehjci\/jet270","article-title":"Assessment of variant forms of Takotsubo cardiomyopathy by two-dimensional speckle tracking echocardiography","volume":"15","author":"David-Cojocariu","year":"2014","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"2026012114220148900_ehf213530-bib-0004","doi-asserted-by":"crossref","first-page":"108","DOI":"10.5582\/irdr.2015.01012","article-title":"Focal mid-ventricular anterior ballooning: an unusual pattern of Takotsubo cardiomyopathy","volume":"4","author":"Demirelli","year":"2015","journal-title":"Intractable Rare Dis Res"},{"key":"2026012114220148900_ehf213530-bib-0005","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s12471-016-0857-z","article-title":"Takotsubo cardiomyopathy: serious early complications and two-year mortality \u2013 a 101 case study","volume":"24","author":"Zalewska-Adamiec","year":"2016","journal-title":"Neth Heart J"},{"key":"2026012114220148900_ehf213530-bib-0006","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.ijcard.2015.03.162","article-title":"Mortality in takotsubo syndrome is similar to mortality in myocardial infarction - A report from the SWEDEHEART registry","volume":"185","author":"Redfors","year":"2015","journal-title":"Int J Cardiol"},{"key":"2026012114220148900_ehf213530-bib-0007","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1001\/jamacardio.2016.1724","article-title":"Potential mortality reduction with optimal implementation of angiotensin receptor neprilysin inhibitor therapy in heart failure","volume":"1","author":"Fonarow","year":"2016","journal-title":"JAMA Cardiol"},{"key":"2026012114220148900_ehf213530-bib-0008","first-page":"1893","article-title":"The role of BNP testing in heart failure","volume":"74","author":"Doust","year":"2006","journal-title":"Am Fam Physician"},{"key":"2026012114220148900_ehf213530-bib-0009","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1161\/CIRCULATIONAHA.108.767012","article-title":"Takotsubo cardiomyopathy: a new form of acute, reversible heart failure","volume":"118","author":"Akashi","year":"2008","journal-title":"Circulation"},{"key":"2026012114220148900_ehf213530-bib-0010","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ijcard.2006.01.034","article-title":"Release pattern of cardiac biomarkers in left ventricular apical ballooning","volume":"115","author":"Nef","year":"2007","journal-title":"Int J Cardiol"},{"key":"2026012114220148900_ehf213530-bib-0011","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.ijcard.2011.09.077","article-title":"Takotsubo cardiomyopathy has a unique cardiac biomarker profile: NT-proBNP\/myoglobin and NT-proBNP\/troponin T ratios for the differential diagnosis of acute coronary syndromes and stress induced cardiomyopathy","volume":"154","author":"Frohlich","year":"2012","journal-title":"Int J Cardiol"},{"key":"2026012114220148900_ehf213530-bib-0012","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.jacc.2019.01.018","article-title":"B-type natriuretic peptide during treatment with sacubitril\/valsartan: the PARADIGM-HF trial","volume":"73","author":"Myhre","year":"2019","journal-title":"J Am Coll Cardiol"},{"key":"2026012114220148900_ehf213530-bib-0013","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1056\/NEJMoa1409077","article-title":"Angiotensin-neprilysin inhibition versus enalapril in heart failure","volume":"371","author":"McMurray","year":"2014","journal-title":"N Engl J Med"},{"key":"2026012114220148900_ehf213530-bib-0014","first-page":"26","article-title":"Sacubitril\/valsartan for chronic heart failure: its future potential","volume":"27","author":"Chaplin","year":"2016","journal-title":"Prescriber"},{"key":"2026012114220148900_ehf213530-bib-0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.cardfail.2018.07.092","article-title":"Reduction of sympathetic innervation following transition to sacubitril\/valsartan in the remodel (Reverse Remodeling Effects of Entresto) study","volume":"24","author":"Sayer","year":"2018","journal-title":"J Card Fail"},{"key":"2026012114220148900_ehf213530-bib-0016","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s10741-018-9757-1","article-title":"Practical guidance on the use of sacubitril\/valsartan for heart failure","volume":"24","author":"Sauer","year":"2019","journal-title":"Heart Fail Rev"},{"key":"2026012114220148900_ehf213530-bib-0017","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1016\/j.ijcard.2012.12.092","article-title":"Novel rat model reveals important roles of beta-adrenoreceptors in stress-induced cardiomyopathy","volume":"168","author":"Shao","year":"2013","journal-title":"Int J Cardiol"},{"key":"2026012114220148900_ehf213530-bib-0018","doi-asserted-by":"crossref","first-page":"H467","DOI":"10.1152\/ajpheart.00734.2013","article-title":"Impaired oxidative metabolism and calcium mishandling underlie cardiac dysfunction in a rat model of post-acute isoproterenol-induced cardiomyopathy","volume":"308","author":"Willis","year":"2015","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2026012114220148900_ehf213530-bib-0019","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.114.000921","article-title":"Functional and histological assessment of an experimental model of Takotsubo's cardiomyopathy","volume":"3","author":"Sachdeva","year":"2014","journal-title":"J Am Heart Assoc"},{"key":"2026012114220148900_ehf213530-bib-0020","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ijcard.2018.12.045","article-title":"Effects of pretreatment with cardiostimulants and beta-blockers on isoprenaline-induced takotsubo-like cardiac dysfunction in rats","volume":"281","author":"Ali","year":"2019","journal-title":"Int J Cardiol"},{"key":"2026012114220148900_ehf213530-bib-0021","doi-asserted-by":"crossref","first-page":"5","DOI":"10.2174\/1871525716666180313121954","article-title":"Entresto, a new Panacea for heart failure?","volume":"16","author":"Khalil","year":"2018","journal-title":"Cardiovasc Hematol Agents Med Chem"},{"key":"2026012114220148900_ehf213530-bib-0022","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1096\/fasebj.14.10.1345","article-title":"Natriuretic peptides: a new lipolytic pathway in human adipocytes","volume":"14","author":"Sengenes","year":"2000","journal-title":"FASEB J"},{"key":"2026012114220148900_ehf213530-bib-0023","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1177\/0091270009343932","article-title":"Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi)","volume":"50","author":"Gu","year":"2010","journal-title":"J Clin Pharmacol"},{"key":"2026012114220148900_ehf213530-bib-0024","doi-asserted-by":"crossref","DOI":"10.1038\/srep27688","article-title":"The BUME method: a new rapid and simple chloroform-free method for total lipid extraction of animal tissue","volume":"6","author":"Lofgren","year":"2016","journal-title":"Sci Rep"},{"key":"2026012114220148900_ehf213530-bib-0025","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1073\/pnas.0811700106","article-title":"Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry","volume":"106","author":"Ejsing","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026012114220148900_ehf213530-bib-0026","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1073\/pnas.94.6.2339","article-title":"Quantitative analysis of biological membrane lipids at the low picomole level by nano-electrospray ionization tandem mass spectrometry","volume":"94","author":"Brugger","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026012114220148900_ehf213530-bib-0027","volume-title":"Prospective ARNI vs ACE Inhibitor Trial to DetermIne Superiority in Reducing Heart Failure Events After MI (PARADISE-MI)","author":"Novartis","year":"2020"},{"key":"2026012114220148900_ehf213530-bib-0028","article-title":"The importance of heart rate in isoprenaline-induced takotsubo-like cardiac dysfunction in rats","author":"Anwar Ali","year":"2020","journal-title":"ESC Heart Fail"},{"key":"2026012114220148900_ehf213530-bib-0029","doi-asserted-by":"crossref","DOI":"10.3390\/metabo10060254","article-title":"The cardiac lipidome in models of cardiovascular disease","volume":"10","author":"Tomczyk","year":"2020","journal-title":"Metabolites."},{"key":"2026012114220148900_ehf213530-bib-0030","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cmet.2012.04.006","article-title":"Lipid metabolism and toxicity in the heart","volume":"15","author":"Goldberg","year":"2012","journal-title":"Cell Metab"},{"key":"2026012114220148900_ehf213530-bib-0031","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1126\/science.abc8861","article-title":"Comprehensive quantification of fuel use by the failing and nonfailing human heart","volume":"370","author":"Murashige","year":"2020","journal-title":"Science"},{"key":"2026012114220148900_ehf213530-bib-0032","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1161\/CIRCRESAHA.116.306842","article-title":"Lipid Use and Misuse by the Heart","volume":"118","author":"Schulze","year":"2016","journal-title":"Circ Res."},{"key":"2026012114220148900_ehf213530-bib-0033","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/ehab412","article-title":"Glucosylceramide synthase deficiency in the heart compromises \u00df1-adrenergic receptor trafficking","author":"Andersson","year":"2021","journal-title":"Eur Heart J"},{"key":"2026012114220148900_ehf213530-bib-0034","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20051149","article-title":"An updated review of lysophosphatidylcholine metabolism in human diseases","volume":"20","author":"Law","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2026012114220148900_ehf213530-bib-0035","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2018.01165","article-title":"Lipidomics reveals a tissue-specific fingerprint","volume":"9","author":"Pradas","year":"2018","journal-title":"Front Physiol"},{"key":"2026012114220148900_ehf213530-bib-0036","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/978-4-431-68482-4_6","volume-title":"Protection Against Ischemia\/Reperfusion Damage of the Heart","author":"Hashizume","year":"1998"},{"key":"2026012114220148900_ehf213530-bib-0037","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0008-6363(97)00203-4","article-title":"Selective impairment of HCO3(-)-dependent pHi regulation by lysophosphatidylcholine in guinea pig ventricular myocardium","volume":"37","author":"Yamaguchi","year":"1998","journal-title":"Cardiovasc Res"},{"key":"2026012114220148900_ehf213530-bib-0038","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/6032631","article-title":"LCZ696 therapy reduces ventricular tachyarrhythmia inducibility in a myocardial infarction-induced heart failure rat model","volume":"2019","author":"Chang","year":"2019","journal-title":"Cardiovasc Ther"},{"key":"2026012114220148900_ehf213530-bib-0039","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1165\/ajrcmb.25.3.4364","article-title":"Role of lysophosphatidylcholine in the desensitization of beta-adrenergic receptors by Ca(2 ) sensitization in tracheal smooth muscle","volume":"25","author":"Kume","year":"2001","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2026012114220148900_ehf213530-bib-0040","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1007\/s00392-019-01440-y","article-title":"Sacubitril\/valsartan reduces ventricular arrhythmias in parallel with left ventricular reverse remodeling in heart failure with reduced ejection fraction","volume":"108","author":"Martens","year":"2019","journal-title":"Clin Res Cardiol"},{"key":"2026012114220148900_ehf213530-bib-0041","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.hfc.2016.06.012","article-title":"The sympathetic nervous system in the pathogenesis of Takotsubo syndrome","volume":"12","author":"Wittstein","year":"2016","journal-title":"Heart Fail Clin"},{"key":"2026012114220148900_ehf213530-bib-0042","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.tcm.2020.04.011","article-title":"The role of the autonomic nervous system in cardiac arrhythmias: the neuro-cardiac axis, more foe than friend?","volume":"31","author":"Manolis","year":"2021","journal-title":"Trends Cardiovasc Med."},{"key":"2026012114220148900_ehf213530-bib-0043","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1161\/CIRCRESAHA.113.302549","article-title":"Role of the autonomic nervous system in modulating cardiac arrhythmias","volume":"114","author":"Shen","year":"2014","journal-title":"Circ Res"},{"key":"2026012114220148900_ehf213530-bib-0044","doi-asserted-by":"crossref","first-page":"NP431","DOI":"10.1093\/asj\/sjz201","article-title":"Takotsubo cardiomyopathy induced by epinephrine infiltration for liposuction: broken heart syndrome","volume":"39","author":"Maes","year":"2019","journal-title":"Aesthet Surg J"},{"key":"2026012114220148900_ehf213530-bib-0045","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.ijcard.2014.04.103","article-title":"Different catecholamines induce different patterns of takotsubo-like cardiac dysfunction in an apparently afterload dependent manner","volume":"174","author":"Redfors","year":"2014","journal-title":"Int J Cardiol"},{"key":"2026012114220148900_ehf213530-bib-0046","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1056\/NEJMoa043046","article-title":"Neurohumoral features of myocardial stunning due to sudden emotional stress","volume":"352","author":"Wittstein","year":"2005","journal-title":"N Engl J Med"},{"key":"2026012114220148900_ehf213530-bib-0047","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0014-2999(78)90292-3","article-title":"Angiotensin II mediation of adrenal catecholamine secretion induced by intrarenal isoprenaline infusion","volume":"52","author":"Feuerstein","year":"1978","journal-title":"Eur J Pharmacol"},{"key":"2026012114220148900_ehf213530-bib-0048","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/cpt.455","article-title":"Improved insulin sensitivity with angiotensin receptor neprilysin inhibition in individuals with obesity and hypertension","volume":"101","author":"Jordan","year":"2017","journal-title":"Clin Pharmacol Therapeut"},{"key":"2026012114220148900_ehf213530-bib-0049","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1161\/HYPERTENSIONAHA.117.10224","article-title":"Effect of sacubitril\/valsartan on exercise-induced lipid metabolism in patients with obesity and hypertension","volume":"71","author":"Engeli","year":"2018","journal-title":"Hypertension"},{"key":"2026012114220148900_ehf213530-bib-0050","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1080\/10641963.2018.1441862","article-title":"Sacubitril and valsartan protect from experimental myocardial infarction by ameliorating oxidative damage in Wistar rats","volume":"41","author":"Imran","year":"2019","journal-title":"Clin Exp Hypertens"},{"key":"2026012114220148900_ehf213530-bib-0051","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1161\/CIRCULATIONAHA.114.013748","article-title":"Angiotensin receptor neprilysin inhibition compared with enalapril on the risk of clinical progression in surviving patients with heart failure","volume":"131","author":"Packer","year":"2015","journal-title":"Circulation"},{"key":"2026012114220148900_ehf213530-bib-0052","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/S0140-6736(12)61227-6","article-title":"The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial","volume":"380","author":"Solomon","year":"2012","journal-title":"Lancet"},{"key":"2026012114220148900_ehf213530-bib-0053","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/j.0305-1870.2004.04073.x","article-title":"Cardioprotective functions of atrial natriuretic peptide and B-type natriuretic peptide: a brief review","volume":"31","author":"Woods","year":"2004","journal-title":"Clin Exp Pharmacol Physiol"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ehf2.13530","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ehf2.13530","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/8\/5\/4130\/65565958\/eschf_8_5_4130.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/8\/5\/4130\/65565958\/eschf_8_5_4130.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T19:27:11Z","timestamp":1769023631000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/8\/5\/4130\/8345806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,30]]},"references-count":53,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,8,30]]},"published-print":{"date-parts":[[2021,10,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ehf2.13530","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,10]]},"published":{"date-parts":[[2021,8,30]]},"assertion":[{"value":"2021-03-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}