{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:42:18Z","timestamp":1769085738493,"version":"3.49.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":1560,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T00:00:00Z","timestamp":1631404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006095","name":"Helse S\u00f8r-\u00d8st RHF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006095","name":"Helse S\u00f8r-\u00d8st RHF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We tested the hypothesis that shortening of time-to-peak left ventricular pressure rise (Td) reflect resynchronization in an animal model and that Td measured in patients will be helpful to identify long-term volumetric responders [end-systolic volume (ESV) decrease &amp;gt;15%] in cardiac resynchronization therapy (CRT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Td was analysed in an animal study (n = 12) of left bundle-branch block (LBBB) with extensive instrumentation to detect left ventricular myocardial deformation, electrical activation, and pressures during pacing. The sum of electrical delays from the onset of pacing to four intracardiac electrodes formed a synchronicity index (SI). Pacing was performed at baseline, with LBBB, right and left ventricular pacing and finally with biventricular pacing (BIVP). We then studied Td at baseline and with BIVP in a clinical observational study in 45 patients during the implantation of CRT and followed up for up to 88 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found a strong relationship between Td and SI in the animals (R = 0.84, P &amp;lt; 0.01). Td and SI increased from narrow QRS at baseline (Td = 95 \u00b1 2 ms, SI = 141 \u00b1 8 ms) to LBBB (Td = 125 \u00b1 2 ms, SI = 247 \u00b1 9 ms, P &amp;lt; 0.01), and shortened with biventricular pacing (BIVP) (Td = 113 \u00b1 2 ms and SI = 192 \u00b1 7 ms, P &amp;lt; 0.01). Prolongation of Td was associated with more wasted deformation during the preejection period (R = 0.77, P &amp;lt; 0.01). Six patients increased ESV by 2.5 \u00b1 18%, while 37 responders (85%) had a mean ESV decrease of 40 \u00b1 15% after more than 6 months of follow-up. Responders presented with a higher Td at baseline than non-responders (163 \u00b1 26 ms vs. 121 \u00b1 19 ms, P &amp;lt; 0.01). Td decreased to 156 \u00b1 16 ms (P = 0.02) with CRT in responders, while in non-responders, Td increased to 148 \u00b1 21 ms (P &amp;lt; 0.01). A decrease in Td with BIVP to values similar or below what was found at baseline accurately identified responders to therapy (AUC 0.98, P &amp;lt; 0.01). Td at baseline and change in Td from baseline was linear related to the decrease in ESV at follow-up. All-cause mortality was high among six non-responders (n = 4), while no patients died in the responder group during follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Prolongation of Td is associated with cardiac dyssynchrony and more wasted deformation during the preejection period. Shortening of a prolonged Td with CRT in patients accurately identifies volumetric responders to CRT with incremental value on top of current guidelines and practices. Thus, Td carries the potential to become a biomarker to predict long-term volumetric response in CRT candidates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13601","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T01:47:29Z","timestamp":1631497649000},"page":"5222-5236","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Shortening of Time-to-Peak Left Ventricular Pressure Rise (Td) in Cardiac Resynchronization Therapy"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0868-4457","authenticated-orcid":false,"given":"Hans Henrik","family":"Odland","sequence":"first","affiliation":[{"name":"Department of Cardiology, Oslo University Hospital , Rikshospitalet, Oslo, 0027 ,","place":["Norway"]},{"name":"Department of Pediatric Cardiology, Oslo University Hospital , Oslo, 0027 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