{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:08:10Z","timestamp":1788480490139,"version":"build-2803163510"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":1544,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K08476"],"award-info":[{"award-number":["20K08476"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K08476"],"award-info":[{"award-number":["20K08476"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study was performed to investigate whether left atrial (LA) strain by echocardiography provides prognostic information in patients with wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Among 129 patients who were diagnosed with ATTRwt-CM at Kumamoto University Hospital from December 2002 to December 2019, 113 patients who had enough information for two-dimensional speckle tracking echocardiography were enrolled in this study. During a median follow-up of 668 days, 28 cardiovascular deaths occurred. Compared with patients in the non-event group, those in the cardiovascular death group were significantly older (81.5 \u00b1 7.4 vs. 78.1 \u00b1 6.1 years, P &amp;lt; 0.01), had a lower incidence of carpal tunnel syndrome (21% vs. 47%, P &amp;lt; 0.05), and had a higher high-sensitivity cardiac troponin T [0.085 (0.063\u20130.105) vs. 0.049 (0.036\u20130.079) ng\/mL, P &amp;lt; 0.01] and B-type natriuretic peptide concentrations [419 (239\u2013541) vs. 271 (155\u2013462) pg\/mL, P &amp;lt; 0.01] and lower estimated glomerular filtration rate (41.8 \u00b1 15.4 vs. 53.4 \u00b1 14.6 mL\/min\/1.73 m2, P &amp;lt; 0.01). Electrocardiography showed higher rate of a V1\u2013V3 QS pattern (52% vs. 24%, P &amp;lt; 0.01) and complete left bundle branch block (27% vs. 6%, P &amp;lt; 0.01), and echocardiography showed a significantly lower peak LA strain rate during the contraction phase (0.16 \u00b1 0.13 vs. 0.28 \u00b1 0.27 S\u22121, P &amp;lt; 0.05), LA strain during the reservoir phase (LASr) (5.84 \u00b1 2.41 vs. 8.22 \u00b1 4.05%, P &amp;lt; 0.01), and peak LA strain rate during the reservoir phase (0.26 \u00b1 0.09 vs. 0.33 \u00b1 0.15 S\u22121, P &amp;lt; 0.05) in the cardiovascular death group than in non-event group. By contrast, conventional echocardiographic findings were not significantly different between these two groups. After adjusting for conventional predictive factors of ATTRwt-CM (age, high-sensitivity cardiac troponin T and B-type natriuretic peptide concentrations, and estimated glomerular filtration rate), multivariable Cox proportional hazard analyses showed that LASr was significantly and independently associated with cardiovascular death in patients with ATTRwt-CM (odds ratio, 0.84; 95% confidence interval, 0.72\u20130.98; P &amp;lt; 0.05). After adjusting for age and echocardiographic findings associated with cardiovascular death (LA volume index and peak LA strain rate during the contraction phase), LASr was significantly and independently associated with cardiovascular death in patients with ATTRwt-CM (odds ratio, 0.83; 95% confidence interval, 0.70\u20130.98; P &amp;lt; 0.05). Receiver operating characteristic curve analysis showed that the area under the curve of LASr for cardiovascular death was 0.686 and that the best cut-off value of LASr was 6.69% (sensitivity, 62.4%; specificity, 64.3%). In the Kaplan\u2013Meier analysis, patients with low LASr (&amp;lt;6.69%) had a significantly higher probability of total cardiovascular death (P &amp;lt; 0.05) and heart failure-related hospitalization (P &amp;lt; 0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Left atrial strain during the reservoir phase provides significant prognostic value in patients with ATTRwt-CM even after adjusting for conventional predictive factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13621","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T08:50:53Z","timestamp":1632819053000},"page":"5316-5326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Prognostic Value of Left Atrial Strain in Patients with Wild-Type Transthyretin Amyloid Cardiomyopathy"],"prefix":"10.1093","volume":"8","author":[{"given":"Fumi","family":"Oike","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University , 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556 ,","place":["Japan"]},{"name":"Center of Metabolic Regulation of Healthy Aging, Kumamoto University Faculty of Life Sciences , Kumamoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Usuku","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University , 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556 ,","place":["Japan"]},{"name":"Center of Metabolic Regulation of Healthy Aging, Kumamoto University Faculty of Life Sciences , Kumamoto ,","place":["Japan"]},{"name":"Department of Laboratory Medicine, Kumamoto University Hospital , Kumamoto 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