{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T09:55:58Z","timestamp":1778666158330,"version":"3.51.4"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":1531,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:00:00Z","timestamp":1633910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC 1116\u2014(project B06, B09)"],"award-info":[{"award-number":["CRC 1116\u2014(project B06, B09)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Susanne-Bunnenberg-Stiftung"},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC 1116\u2014(project B06 to M.K. and C.J., project B09 to N.G., and Gerok rotation to P.W.)"],"award-info":[{"award-number":["CRC 1116\u2014(project B06 to M.K. and C.J., project B09 to N.G., and Gerok rotation to P.W.)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Iron deficiency is frequently observed in patients with acute coronary syndrome and associates with poor prognosis after acute myocardial infarction (AMI). Anaemia is linked to dysregulation of iron metabolism, red blood cell dysfunction, and increased reactive oxygen species generation. Iron supplementation in chronic heart failure is safe and improves cardiac exercise capacity. Increases in iron during ischaemia or immediately after reperfusion are associated with detrimental effects on left ventricular (LV) function. The safety and applicability of iron during or immediately after reperfusion of AMI in anaemia are not known. We aimed to study the safety and efficacy of iron supplementation within 1 h or deferred to 24 h after reperfusion of AMI by analysing LV function and infarct size.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>In a mouse model of moderate blood loss anaemia (n = 6\u20138 mice\/group), the effects of iron supplementation (20 mg iron as ferric carboxymaltose per kg body weight) within 1 h and deferred to 24 h after ischaemia\/reperfusion were assessed. Cardiac function was analysed in vivo by echocardiography at baseline (Day 3) with and without anaemia, after AMI (24 h), and after administration of intravenous iron. Anaemia was characterized by iron deficiency and a trend towards increased haemolysis, which was supported by increased plasma free-haemoglobin [sham vs. anaemia (n = 8\/group): P &amp;lt; 0.05]. Anaemia increased heart rate, LV end-diastolic volume, stroke volume, and cardiac output, while LV end-systolic volume remained unchanged at baseline. Superimposition of AMI deteriorated global LV function, whereas infarct sizes remained unaffected [sham vs. anaemia (n = 6\/group): P = 0.9]. Deferred iron supplementation 24 h after ischaemia\/reperfusion resulted in reversal of end-systolic volume increase and reduced infarct size [% of area at risk: sham vs. anaemia + iron after 24 h; (n = 6\/group); 48 \u00b1 7 vs. 38 \u00b1 7; P &amp;lt; 0.05], whereas administration within 1 h after reperfusion was neutral [sham vs. anaemia + iron; (n = 6\/group); 48 \u00b1 7 vs. 42 \u00b1 8; P = 0.56]. Moreover, iron application after reperfused AMI showed unaltered mortality compared with sham.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Iron supplementation 24 h after reperfusion of AMI is safe and reversed enlargement of end-systolic volume after AMI resulting in increased stroke volume and cardiac output. This highlights its potential as adjunctive treatment in anaemia with ID after reperfused AMI. Time point of iron application after reperfusion appears critical.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13639","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T15:37:14Z","timestamp":1634139434000},"page":"5445-5455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Safety and Efficacy of Iron Supplementation After Myocardial Infarction in Mice with Moderate Blood Loss Anaemia"],"prefix":"10.1093","volume":"8","author":[{"given":"Patricia","family":"Wischmann","sequence":"first","affiliation":[{"name":"Department of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich-Heine University , Moorenstr. 5, D\u00fcsseldorf, 40225 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramesh","family":"Chennupati","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich-Heine University , Moorenstr. 5, D\u00fcsseldorf, 40225 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Solga","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich-Heine University , Moorenstr. 5, D\u00fcsseldorf, 40225 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Funk","sequence":"additional","affiliation":[{"name":"Department of Nanomedicines, Vifor Pharma Management Ltd , Glattbrugg ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Becher","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich-Heine University , Moorenstr. 5, D\u00fcsseldorf, 40225 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