{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:52:31Z","timestamp":1769086351524,"version":"3.49.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":1509,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T00:00:00Z","timestamp":1635811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2018YFC1002403"],"award-info":[{"award-number":["2018YFC1002403"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1002403"],"award-info":[{"award-number":["2018YFC1002403"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The management of heart failure (HF) in young children is challenging. The present study aimed to clarify the effect of left univentricular epicardial pacing on dilated cardiomyopathy with left bundle branch block (LBBB) in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>A total of five cases (30.86 \u00b1 16.39 months, three female) of children weighing 5.8\u201315 kg with dilated cardiomyopathy and LBBB were included in this study. LBBB in one child occurred after device closure of peri-membranous ventricular septal defects, and the remaining four were idiopathically discovered early after birth. Before implantation, all children suffered from refractory HF and cardiac dilatation; the left ventricular ejection fraction was 33.48 \u00b1 5.84% with Ross Heart Failure Classification III\u2013IV. Electrical and mechanical dyssynchrony were observed in all children with QRS duration &amp;gt;140 ms and prolonged septal-to-left posterior wall motion delay. Left univentricular epicardial pacing was successfully implanted via left axillary minithoracotomy in the five children. Sensed atrioventricular delays (83 \u00b1 15 ms) were optimized by velocity time integral of aortic blood flow before discharge. During the follow-up period (10.8 \u00b1 2.68 months), the dilated failing heart was reversed significantly in terms of decreased left ventricular dimension (55.62 \u00b1 3.46 vs. 38.94 \u00b1 3.69 mm, P = 0.005), while the left ventricular ejection fraction improved to 60.18 \u00b1 8.78% (P = 0.006).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In young children with low body weight, if HF is caused by or related to LBBB, left ventricular epicardial pacing still has an excellent effect.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13657","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T22:57:39Z","timestamp":1635893859000},"page":"4772-4779","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Left Ventricular Epicardial Pacing Achieved Hyper-Responsiveness in Young Children with Dilated Cardiomyopathy with Left Bundle Branch Block"],"prefix":"10.1093","volume":"8","author":[{"given":"Sijuan","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Cardiology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University , Shanghai, 200127 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fujian Children's Hospital, Affiliated Hospital of Fujian Medical University , Fuzhou ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiwei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University , Shanghai, 200127 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