{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:21:54Z","timestamp":1769084514795,"version":"3.49.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":1492,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,11,4]],"date-time":"2021-11-04T00:00:00Z","timestamp":1635984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Projekt DEAL"},{"DOI":"10.13039\/100001316","name":"Abbott","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["322900939"],"award-info":[{"award-number":["322900939"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["322900939"],"award-info":[{"award-number":["322900939"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Control of pulmonary pressures monitored remotely reduced heart failure hospitalizations mainly by lowering filling pressures through the use of loop diuretics. Sacubitril\/valsartan improves heart failure outcomes and increases the kidney sensitivity for diuretics. We explored whether sacubitril\/valsartan is associated with less utilization of loop diuretics in patients guided with haemodynamic monitoring in the CardioMEMS European Monitoring Study for Heart Failure (MEMS-HF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>The MEMS-HF population (n = 239) was separated by the use of sacubitril\/valsartan (n = 68) or no use of it (n = 164). Utilization of diuretics and their doses was prespecified in the protocol and was monitored in both groups. Multivariable regression, ANCOVA, and a generalized linear model were used to fit baseline covariates with furosemide equivalents and changes for 12 months. MEMS-HF participants (n = 239) were grouped in sacubitril\/valsartan users [n = 68, 64 \u00b1 11 years, left ventricular ejection fraction (LVEF) 25 \u00b1 9%, cardiac index (CI) 1.89 \u00b1 0.4 L\/min\/m2] vs. non-users (n = 164, 70 \u00b1 10 years, LVEF 36 \u00b1 16%, CI 2.11 \u00b1 0.58 L\/min\/m2, P = 0.0002, P &amp;lt; 0.0001, and P = 0.0015, respectively). In contrast, mean pulmonary artery pressure (PAP) values were comparable between groups (29 \u00b1 11 vs. 31 \u00b1 11 mmHg, P = 0.127). Utilization of loop diuretics was lower in patients taking sacubitril\/valsartan compared with those without (P = 0.01). Significant predictor of loop diuretic use was a history of renal failure (P = 0.005) but not age (P = 0.091). After subjects were stratified by sacubitril\/valsartan or other diuretic use, PAP was nominally, but not significantly lower in sacubitril\/valsartan-treated patients (baseline: P = 0.52; 6 months: P = 0.07; 12 months: P = 0.53), while there was no difference in outcome or PAP changes. This difference was observed despite lower CI (P = 0.0015). Comparable changes were not observed for other non-loop diuretics (P = 0.21).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients whose treatment was guided by remote PAP monitoring, concomitant use of sacubitril\/valsartan was associated with reduced utilization of loop diuretics, which could potentially be relevant for outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13665","type":"journal-article","created":{"date-parts":[[2021,11,4]],"date-time":"2021-11-04T20:10:07Z","timestamp":1636056607000},"page":"155-163","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Less Loop Diuretic Use in Patients on Sacubitril\/Valsartan Undergoing Remote Pulmonary Artery Pressure Monitoring"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2976-2514","authenticated-orcid":false,"given":"Michael","family":"B\u00f6hm","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universit\u00e4tsklinikum des Saarlandes, Saarland University , Kirrberger Str. 1, Homburg\/Saar, 66421 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Assmus","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cardiology, Goethe University Hospital, Frankfurt , Frankfurt am Main ,","place":["Germany"]},{"name":"Department of Medicine I, Cardiology\/Angiology, University Hospital , Giessen ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan D.","family":"Anker","sequence":"additional","affiliation":[{"name":"Division of Cardiology & Metabolism and Department of Cardiology & Berlin-Brandenburg Center for Regenerative Therapies, and German Center for Cardiovascular Research, partner site Berlin, Charit\u00e9 Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Folkert W.","family":"Asselbergs","sequence":"additional","affiliation":[{"name":"Division Heart & Lungs, Department of Cardiology, University Medical Centre Utrecht , Utrecht ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Brachmann","sequence":"additional","affiliation":[{"name":"Medical Centre Coburg GmbH II, Medical Clinic Cardiology, Angiology, Pulmonology , Coburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Elena","family":"Brett","sequence":"additional","affiliation":[{"name":"Abbott , Sylmar, CA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasper J.","family":"Brugts","sequence":"additional","affiliation":[{"name":"Erasmus MC University Medical Center, Thorax Center , Rotterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Ertl","sequence":"additional","affiliation":[{"name":"Comprehensive Heart Failure Center, University and University Hospital W\u00fcrzburg , W\u00fcrzburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AiJia","family":"Wang","sequence":"additional","affiliation":[{"name":"Abbott , Sylmar, CA ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutz","family":"Hilker","sequence":"additional","affiliation":[{"name":"Klinikum Karlsburg, Heart and Diabetes Center Mecklenburg-Western Pommerania , Karlsburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedrich","family":"Koehler","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Angiology, Medical Department, Campus Charit\u00e9 Mitte, Centre for Cardiovascular Telemedicine, Charit\u00e9 Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Rosenkranz","sequence":"additional","affiliation":[{"name":"Clinic III for Internal Medicine, University of Cologne Heart Center, and Cologne Cardiovascular Research Center (CCRC) , K\u00f6ln ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Leistner","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center Berlin and Charite University Medicine Berlin, Campus Benjamin-Franklin (CBF) , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amr","family":"Abdin","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universit\u00e4tsklinikum des Saarlandes, Saarland University , Kirrberger Str. 1, Homburg\/Saar, 66421 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Wintrich","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universit\u00e4tsklinikum des Saarlandes, Saarland University , Kirrberger Str. 1, Homburg\/Saar, 66421 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology I, University Heart Center Freiburg - Bad Krozingen, University of Freiburg , Bad Krozingen ,","place":["Germany"]},{"name":"Department of Cardiology, University Hospital Basel , Basel ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip 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