{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:43:02Z","timestamp":1784641382654,"version":"3.55.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":1512,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T00:00:00Z","timestamp":1635552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900361"],"award-info":[{"award-number":["81900361"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900361"],"award-info":[{"award-number":["81900361"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to investigate whether sacubitril\u2013valsartan could further improve the prognosis, cardiac function, and left ventricular (LV) remodelling in patients following acute myocardial infarction (AMI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We searched the PubMed, Embase, Cochrane Library, and China National Knowledge Infrastructure (CNKI) from inception to 10 May 2021 to identify potential articles. Randomized controlled trials (RCTs) meeting the inclusion criteria were included and analysed. Thirteen RCTs, covering 1358 patients, were analysed. Compared with angiotensin-converting enzyme inhibitors (ACEI)\/angiotensin receptor blockers (ARB), sacubitril\u2013valsartan did not significantly reduced the cardiovascular mortality [risk ratio (RR) 0.65, 95% confidence interval (CI) 0.22 to 1.93, P = 0.434] and the rate of myocardial reinfarction (RR 0.65, 95% CI 0.29 to 1.46, P = 0.295) of patients following AMI, but the rate of hospitalization for heart failure (HF) (RR 0.48, 95% CI 0.35 to 0.66, P &amp;lt; 0.001) and the change of LV ejection fraction (LVEF) [weighted mean difference (WMD) 5.49, 95% CI 3.62 to 7.36, P &amp;lt; 0.001] were obviously improved. The N-terminal pro-brain natriuretic peptide (NT-ProBNP) level (WMD \u2212310.23, 95% CI \u2212385.89 to \u2212234.57, P &amp;lt; 0.001) and the LV end-diastolic dimension (LVEDD) (WMD \u22123.16, 95% CI \u22124.59 to \u22121.73, P &amp;lt; 0.001) were also significantly lower in sacubitril\u2013valsartan group than in ACEI\/ARB group. Regarding safety, sacubitril\u2013valsartan did not increase the risk of hypotension, hyperkalaemia, angioedema, and cough.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This meta-analysis suggests that early administration of sacubitril\u2013valsartan may be superior to conventional ACEI\/ARB to decrease the risk of hospitalization for HF, improve the cardiac function, and reverse the LV remodelling in patients following AMI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13677","type":"journal-article","created":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T06:26:29Z","timestamp":1635575189000},"page":"4852-4862","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The Benefits of Sacubitril\u2013Valsartan in Patients with Acute Myocardial Infarction: A Systematic Review and Meta-Analysis"],"prefix":"10.1093","volume":"8","author":[{"given":"Bo","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University , No. 76, Linjiang Road, Chongqing, 400010 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Chongqing Traditional Chinese Medicine Hospital, Chongqing Academy of Traditional Chinese Medicine , Chongqing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University , No. 76, Linjiang Road, Chongqing, 400010 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanqing","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University , No. 76, Linjiang Road, Chongqing, 400010 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University , No. 76, Linjiang Road, Chongqing, 400010 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunkang","family":"Rong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University , No. 76, Linjiang Road, Chongqing, 400010 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Que","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University , No. 76, Linjiang Road, Chongqing, 400010 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University , No. 76, Linjiang Road, Chongqing, 400010 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University , No. 76, Linjiang Road, Chongqing, 400010 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University , No. 76, Linjiang Road, Chongqing, 400010 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,10,30]]},"reference":[{"key":"2026012114190464000_ehf213677-bib-0001","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ahj.2012.12.005","article-title":"Incidence of heart failure and mortality after acute coronary syndromes","volume":"165","author":"Kaul","year":"2013","journal-title":"Am Heart J"},{"key":"2026012114190464000_ehf213677-bib-0002","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1161\/01.CIR.0000108928.25690.94","article-title":"Effects of carvedilol on left ventricular remodeling after acute myocardial infarction: the CAPRICORN Echo Substudy","volume":"109","author":"Doughty","year":"2004","journal-title":"Circulation"},{"key":"2026012114190464000_ehf213677-bib-0003","first-page":"821","article-title":"Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure. 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