{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T07:50:45Z","timestamp":1790495445829,"version":"4.1.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":1467,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T00:00:00Z","timestamp":1638144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"University Research Federation against Heart Failure","award":["FHU2019 Prevent_Heart Failure"],"award-info":[{"award-number":["FHU2019 Prevent_Heart Failure"]}]},{"name":"Investments for the Future Programme","award":["2018-PSPC-07"],"award-info":[{"award-number":["2018-PSPC-07"]}]},{"DOI":"10.13039\/501100002738","name":"Assistance Publique - H\u00f4pitaux de Paris","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002738","name":"Assistance Publique - H\u00f4pitaux de Paris","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome with various causes that may influence prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We extracted the electronic medical records for 2180 consecutive patients hospitalized between 2016 and 2019 for decompensated heart failure. Using a text mining algorithm looking for a left ventricular ejection fraction \u226550% and plasma brain natriuretic peptide level &amp;gt;100 pg\/mL, we identified 928 HFpEF patients. We screened for a prevailing cause of HFpEF according to European guidelines and found that 418 (45.0%) patients had secondary HFpEF due to either myocardial (n = 125, 13.5%) or loading condition abnormalities (n = 293, 31.5%), while the remaining 510 (55.0%) patients had idiopathic HFpEF. We assessed the association between the causes of HFpEF and survival collected up to 31 December 2020 using Cox proportional hazards analysis. Even though patients with idiopathic HFpEF were older, frequently female, and had frequent co-morbidities and a higher crude mortality rate compared with secondary HFpEF patients, their prognosis was similar after adjustment for age and sex. Unsupervised clustering analysis revealed three main phenogroups with different distribution of idiopathic vs. secondary HFpEF. The phenogroup with the highest proportion of idiopathic HFpEF (69%) had (i) an excess rate of non-cardiac co-morbidities including chronic obstructive pulmonary disease (31%) or obesity (41%) and (ii) a better prognosis compared with the two other phenogroups enriched with secondary HFpEF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Aetiological classification provides clinical and prognostic information and may be useful to better decipher the clinical heterogeneity of HFpEF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13717","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T03:20:05Z","timestamp":1638156005000},"page":"519-530","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Aetiological Classification and Prognosis in Patients with Heart Failure with Preserved Ejection Fraction"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4608-2649","authenticated-orcid":false,"given":"Antoine","family":"Fayol","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Paris, INSERM, PARCC , Paris, F-75006 ,","place":["France"]},{"name":"CIC1418 and DMU CARTE, Assistance Publique\u2014H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Europ\u00e9en Georges-Pompidou , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Wack","sequence":"additional","affiliation":[{"name":"Centre de Recherche des Cordeliers, Sorbonne Universit\u00e9, Universit\u00e9 de Paris, Inserm , Paris ,","place":["France"]},{"name":"Departement d'Informatique Hospitali\u00e8re, DMU PRIME, Assistance Publique\u2014H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Europ\u00e9en Georges-Pompidou , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Livrozet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, INSERM, PARCC , Paris, F-75006 ,","place":["France"]},{"name":"CIC1418 and DMU CARTE, Assistance Publique\u2014H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Europ\u00e9en Georges-Pompidou , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2234-3728","authenticated-orcid":false,"given":"Jean-Baptiste","family":"Carves","sequence":"additional","affiliation":[{"name":"CIC1418 and DMU CARTE, Assistance Publique\u2014H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Europ\u00e9en Georges-Pompidou , Paris 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