{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T21:33:45Z","timestamp":1783719225790,"version":"3.55.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":1422,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T00:00:00Z","timestamp":1642032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Gansu Natural Science Foundation Project","award":["21JR1RG306"],"award-info":[{"award-number":["21JR1RG306"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Myocardial infarction (MI) is a type of cardiovascular disease caused by myocardial necrosis. Growing evidences have suggested that circular RNAs (circRNAs) play crucial roles in cardiac hypoxia\/reoxygenation (H\/R)-induced injury of MI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Hypoxia\/reoxygenation model of H9C2 cells was established and circ_0001206 expression was detected via quantitative real-time polymerase chain reaction. Ribonuclease R (RNase R) and Actinomycin D (Act D) assays verified the stability. Cell counting kit-8 (CCK-8), western blot, TUNEL, and flow cytometry assays evaluated cell viability and cell apoptosis. RNA pull-down, RNA binding protein immunoprecipitation (RIP), and luciferase reporter assays explored the mechanisms underlying MI. All experimental data were presented with mean \u00b1 standard deviation (SD) and P &amp;lt; 0.05 indicated statistical significance. Circ_0001206 was low-expressed in H9C2 cells under H\/R treatment. Circ_0001206 was formed by cyclization of CRK like proto-oncogene, adaptor protein (CRKL). Circ_0001206 overexpression promoted cell viability and inhibited cardiomyocyte apoptosis. It was confirmed that circ_0001206 regulated CRKL expression via acting as a competing endogenous RNA (ceRNA) of microRNA-665 (miR-665). CRKL played a protective role in MI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Circ_0001206 regulates miR-665\/CRKL axis to alleviate H\/R-induced cardiomyocyte injury in MI. Our findings suggest that circ_0001206 might be a potential target for MI treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13725","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T03:48:51Z","timestamp":1642045731000},"page":"998-1007","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Circ_0001206 Regulates miR-665\/CRKL Axis to Alleviate Hypoxia\/Reoxygenation-Induced Cardiomyocyte Injury in Myocardial Infarction"],"prefix":"10.1093","volume":"9","author":[{"given":"Dongmei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Zhang Ye People's Hospital Affiliated to Hexi University , Zhangye ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limei","family":"Tian","sequence":"additional","affiliation":[{"name":"Medical College of Hexi University , Zhangye ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhang Ye People's Hospital Affiliated to Hexi University , Zhangye ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Zhang Ye People's Hospital Affiliated to Hexi University , Zhangye ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanbo","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Gansu Provincial Maternity and Child-care Hospital , No.143 North Qilihe Street, Lanzhou, Gansu, 730050 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbo","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Gansu Provincial Maternity 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