{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T21:09:51Z","timestamp":1769116191220,"version":"3.49.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":1450,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Health, Labour and Welfare Policy Research Grants for Research on Policy Planning and Evaluation","award":["20AA2005"],"award-info":[{"award-number":["20AA2005"]}]},{"name":"GAP Fund Program of Kyoto University type B"},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["20HA2003"],"award-info":[{"award-number":["20HA2003"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19H01075"],"award-info":[{"award-number":["JP19H01075"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["20HA2003"],"award-info":[{"award-number":["20HA2003"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP19H01075"],"award-info":[{"award-number":["JP19H01075"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The Coronavirus Disease 2019 (COVID-19) pandemic has had unprecedented effects on health care utilization for acute cardiovascular diseases. Although hospitalizations for acute coronary syndrome decreased during the COVID-19 pandemic, there is a paucity of data on the trends and management of heart failure (HF) cases. Furthermore, concerns have been raised that angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) may increase susceptibility to COVID-19. This study aimed to elucidate changes in HF hospitalizations from the COVID-19 state of emergency in Japan and investigated changes in the prescription of ACEIs and ARBs, and in-hospital mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We performed an interrupted time series analysis of HF hospitalizations in Japan to verify the impacts of the COVID-19 state of emergency. Changes in the weekly volume of HF hospitalizations were taken as the primary outcome measure. Between 1 April 2018 and 4 July 2020, 109 429 HF cases required admission. After the state of emergency, an immediate decrease was observed in HF cases per week [\u22123.6%; 95% confidence interval (CI): \u22120.3% to \u22126.7%, P = 0.03]. There was no significant change in the prescription of ACEIs or ARBs after the state of emergency (4.2%; 95% CI: \u22120.3% to 8.9%, P = 0.07). The COVID-19 pandemic had no effect on in-hospital mortality among HF patients (5.3%; 95% CI: \u22124.9% to 16.6%, P = 0.32).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We demonstrated a decline in HF hospitalizations during the COVID-19 pandemic in Japan, with no clear evidence of a negative effect on the prescription of ACEIs and ARBs or in-hospital mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13744","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T04:36:54Z","timestamp":1639629414000},"page":"31-38","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Effects of the COVID-19 Pandemic on Heart Failure Hospitalizations in Japan: Interrupted Time Series Analysis"],"prefix":"10.1093","volume":"9","author":[{"given":"Tetsuji","family":"Morishita","sequence":"first","affiliation":[{"name":"Department of Healthcare Economics and Quality Management, Graduate School of Medicine, Kyoto University , Yoshida Konoe-cho, Sakyo-ku, Kyoto City, Kyoto, 606-8501 ,","place":["Japan"]},{"name":"Department of Internal Medicine, Matsunami General Hospital , Gifu ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Takada","sequence":"additional","affiliation":[{"name":"Department of Healthcare Economics and Quality Management, Graduate School of Medicine, Kyoto University , Yoshida Konoe-cho, Sakyo-ku, Kyoto City, Kyoto, 606-8501 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-ho","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Healthcare Economics and Quality Management, Graduate School of Medicine, Kyoto University , Yoshida Konoe-cho, Sakyo-ku, Kyoto City, Kyoto, 606-8501 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Department of Healthcare Economics and Quality Management, Graduate School of Medicine, Kyoto University , Yoshida Konoe-cho, Sakyo-ku, Kyoto City, Kyoto, 606-8501 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Kunisawa","sequence":"additional","affiliation":[{"name":"Department of Healthcare Economics and Quality Management, Graduate School of Medicine, Kyoto University , Yoshida Konoe-cho, Sakyo-ku, Kyoto City, Kyoto, 606-8501 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyohide","family":"Fushimi","sequence":"additional","affiliation":[{"name":"Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School , Tokyo 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