{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T07:05:20Z","timestamp":1782457520017,"version":"3.54.5"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":1410,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T00:00:00Z","timestamp":1643068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015639","name":"Japan Cardiovascular Research Foundation","doi-asserted-by":"publisher","award":["24-4-2"],"award-info":[{"award-number":["24-4-2"]}],"id":[{"id":"10.13039\/100015639","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015639","name":"Japan Cardiovascular Research Foundation","doi-asserted-by":"publisher","award":["24\u20104\u20102"],"award-info":[{"award-number":["24\u20104\u20102"]}],"id":[{"id":"10.13039\/100015639","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Increased left ventricular mass index (LVMI) disproportionate to electrocardiographic QRS voltage has been reported to be associated with cardiac fibrosis and amyloid infiltration to myocardium. This study aimed to assess whether the LVMI-to-QRS-voltage ratio predicts clinical outcomes in heart failure with preserved ejection fraction (HFpEF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>The Japanese Heart Failure Syndrome with Preserved Ejection Fraction (JASPER) registry is a nationwide, observational, and prospective registration of Japanese patients hospitalized with HFpEF (EF \u2265 50%). LVMI was assessed by echocardiography using the cube formula. QRS voltage was assessed by Sokolow\u2013Lyon voltage criteria. We divided 290 patients in the registry who met inclusion criteria into five groups according to the quintile values of their LVMI-to-QRS-voltage ratio. In the highest quintile group (\u226571.8 g\/m2\/mV), approximately 50% of the patients had concentric hypertrophy and 30% had eccentric hypertrophy. These patients had the highest proportion of atrial fibrillation (61.4%) and history of pacemaker implantation (12.1%) among the five groups (P &amp;lt; 0.05). During the mean follow-up of 587 \u00b1 300 days, 31.4% of all patients met the composite endpoint of all-cause death or rehospitalization for HF. Even after adjustment for demographic and baseline variables, the highest quintile group had a significantly higher incidence of the composite endpoints than the lowest quintile group (&amp;lt;30.7 g\/m2\/mV) (hazard ratio: 2.205, 95% confidence interval: 1.106\u20134.395, P &amp;lt; 0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A high LVMI-to-QRS-voltage ratio is independently associated with poor outcomes in patients with HFpEF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13778","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T09:06:10Z","timestamp":1643101570000},"page":"1098-1106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Left Ventricular Mass Index-to-QRS-Voltage Ratio Predicts Outcomes in Heart Failure with Preserved Ejection Fraction"],"prefix":"10.1093","volume":"9","author":[{"given":"Yoshiharu","family":"Kinugasa","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine and Endocrinology and Metabolism, Faculty of Medicine, Tottori University , 36-1 Nishicho, Yonago, 683-8504 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine and Endocrinology and Metabolism, Faculty of Medicine, Tottori University , 36-1 Nishicho, Yonago, 683-8504 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Kamitani","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine and Endocrinology and Metabolism, Faculty of Medicine, Tottori University , 36-1 Nishicho, Yonago, 683-8504 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Hirai","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine and Endocrinology and Metabolism, Faculty of Medicine, Tottori University , 36-1 Nishicho, Yonago, 683-8504 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyotaka","family":"Yanagihara","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine and Endocrinology and Metabolism, Faculty of Medicine, Tottori University , 36-1 Nishicho, Yonago, 683-8504 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Science and Technology, School of Health Science; Major in Clinical Laboratory Science, Faculty of Medicine, Tottori University , Yonago ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Nagai","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University , Sapporo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sakakibara Heart Institute , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Nara Medical University , Kashihara ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuchika","family":"Takeishi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Fukushima Medical University , Fukushima ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine and Endocrinology and Metabolism, Faculty of Medicine, Tottori University , 36-1 Nishicho, Yonago, 683-8504 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihisa","family":"Anzai","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University , Sapporo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,1,25]]},"reference":[{"key":"2026012114163505900_ehf213778-bib-0001","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1161\/CIRCULATIONAHA.111.080770","article-title":"Trends in patients hospitalized with heart failure and preserved left ventricular ejection fraction: 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