{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T14:01:15Z","timestamp":1775311275306,"version":"3.50.1"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":1398,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2022,2,6]],"date-time":"2022-02-06T00:00:00Z","timestamp":1644105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006484","name":"Vifor Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006484","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006484","name":"Vifor Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Iron deficiency (ID) is common in patient with chronic heart failure (HF) and has been widely studied. In contrast, data concerning ID in cardiac amyloidosis (CA) are limited. Amyloidosis is a severe and fatal systemic disease, characterized by an accumulation of amyloid fibrils in various tissues\/organs, including nerves, kidneys, gastrointestinal tract, and heart. Amyloid deposits in the heart eventually cause HF. The main subtypes of CA are light chain (AL), hereditary transthyretin (ATTRv), and wild-type transthyretin (ATTRwt). We performed this study to determine the prevalence, clinical outcome (all-cause mortality), and determinants of ID among the three main subtypes of CA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Iron deficiency status were analysed in 816 CA patients enrolled at the French Referral Centre for Cardiac Amyloidosis: 271 (33%) had AL, 164 (20%) ATTRv, and 381 (47%) ATTRwt. ID affected 49% of CA patients, 45% with AL, 58% with ATTRv, and 48% with ATTRwt. We identified ATTR status (ATTRv P = 0.003, ATTRwt P = 0.037), diabetes (P = 0.003), aspirin treatment (P = 0.009), haemoglobin levels (P = 0.006), and altered global longitudinal strain (P = 0.02) as independent ID determinants. There is no difference in all-cause mortality considering ID status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Iron deficiency is common in patients with CA, irrespective of the subtype. Patients seem more likely to have ID if diagnosed with ATTR, if diabetic, and\/or treated with aspirin. In CA, the benefit of intravenous iron therapy, for ID, on morbidity and mortality needs further study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13818","type":"journal-article","created":{"date-parts":[[2022,2,6]],"date-time":"2022-02-06T22:08:46Z","timestamp":1644185326000},"page":"1314-1327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Prevalence and Determinants of Iron Deficiency in Cardiac Amyloidosis"],"prefix":"10.1093","volume":"9","author":[{"given":"Antoine","family":"Jobb\u00e9-Duval","sequence":"first","affiliation":[{"name":"Heart Failure and Transplant Department, \u2018Louis Pradel\u2019 Cardiologic Hospital, Hospices Civils de Lyon , Lyon ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e9lanie","family":"B\u00e9zard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, French Referral Centre for Cardiac Amyloidosis, Cardiogen Network, GRC Amyloid Research Institute, DHU A-TVB, InsermU955, Henri Mondor Teaching Hospital, APHP , 51 Avenue Marechal de Lattre de Tassigny, Creteil, 94000 ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Moutereau","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Henri Mondor Teaching Hospital, APHP , Creteil ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mounira","family":"Kharoubi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, French Referral Centre for Cardiac Amyloidosis, Cardiogen Network, GRC Amyloid Research Institute, DHU A-TVB, InsermU955, Henri Mondor Teaching Hospital, APHP , 51 Avenue Marechal de Lattre de Tassigny, Creteil, 94000 ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Oghina","sequence":"additional","affiliation":[{"name":"Department of Cardiology, French Referral Centre for Cardiac Amyloidosis, Cardiogen Network, GRC Amyloid Research Institute, DHU A-TVB, InsermU955, Henri Mondor Teaching Hospital, APHP , 51 Avenue Marechal de Lattre de Tassigny, Creteil, 94000 ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amira","family":"Zaroui","sequence":"additional","affiliation":[{"name":"Department of Cardiology, French Referral Centre for Cardiac Amyloidosis, Cardiogen Network, GRC Amyloid Research Institute, DHU A-TVB, InsermU955, Henri Mondor Teaching Hospital, APHP , 51 Avenue Marechal de Lattre de Tassigny, Creteil, 94000 ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnault","family":"Galat","sequence":"additional","affiliation":[{"name":"Department of Cardiology, French Referral Centre for Cardiac Amyloidosis, Cardiogen Network, GRC Amyloid Research Institute, DHU A-TVB, InsermU955, Henri Mondor Teaching Hospital, APHP , 51 Avenue Marechal de Lattre de Tassigny, Creteil, 94000 ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coraline","family":"Chalard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, French Referral Centre for Cardiac Amyloidosis, Cardiogen Network, GRC Amyloid Research Institute, DHU A-TVB, InsermU955, Henri Mondor Teaching Hospital, APHP , 51 Avenue Marechal de Lattre de Tassigny, Creteil, 94000 ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Hugon-Vallet","sequence":"additional","affiliation":[{"name":"Heart Failure and Transplant Department, \u2018Louis Pradel\u2019 Cardiologic Hospital, Hospices Civils de Lyon , Lyon ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois","family":"Lemonnier","sequence":"additional","affiliation":[{"name":"Department of Haematology, Henri Mondor Teaching Hospital, APHP , Creteil ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien","family":"Eyharts","sequence":"additional","affiliation":[{"name":"Department of Cardiology, French Referral Centre for Cardiac Amyloidosis, Cardiogen Network, GRC Amyloid Research Institute, DHU A-TVB, InsermU955, Henri Mondor Teaching Hospital, APHP , 51 Avenue Marechal de Lattre de Tassigny, Creteil, 94000 ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsa","family":"Poulot","sequence":"additional","affiliation":[{"name":"Department of Pathology, Henri Mondor Teaching Hospital, APHP , Creteil ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascale","family":"Fanen","sequence":"additional","affiliation":[{"name":"Department of Genetics, Henri Mondor Teaching Hospital, APHP , Creteil ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benoit","family":"Funalot","sequence":"additional","affiliation":[{"name":"Department of Genetics, Henri Mondor Teaching Hospital, APHP , Creteil ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Molinier-Frenkel","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Henri Mondor Teaching Hospital, APHP , Creteil ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Audard","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Henri Mondor Teaching Hospital, APHP , Creteil ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc","family":"Hittinger","sequence":"additional","affiliation":[{"name":"Department of Cardiology, French Referral Centre for Cardiac Amyloidosis, Cardiogen Network, GRC Amyloid Research Institute, DHU A-TVB, InsermU955, Henri Mondor Teaching Hospital, APHP , 51 Avenue Marechal de Lattre de Tassigny, Creteil, 94000 ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc Antoine","family":"Delbarre","sequence":"additional","affiliation":[{"name":"Department of Cardiology, French Referral Centre for Cardiac Amyloidosis, Cardiogen Network, GRC Amyloid Research Institute, DHU A-TVB, InsermU955, Henri Mondor Teaching Hospital, APHP , 51 Avenue Marechal de Lattre de Tassigny, Creteil, 94000 ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Teiger","sequence":"additional","affiliation":[{"name":"Department of 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