{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:56:55Z","timestamp":1789685815333,"version":"4.0.1"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":1382,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["21K08131"],"award-info":[{"award-number":["21K08131"]}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["20ek0109466h0001"],"award-info":[{"award-number":["20ek0109466h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K08131"],"award-info":[{"award-number":["21K08131"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["20ek0109466h0001"],"award-info":[{"award-number":["20ek0109466h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>It has been reported that a staging system combining N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin T (hs-cTnT) or estimated glomerular filtration rate (eGFR) is useful in patients with wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM). However, these studies were mainly conducted in Western countries, and their usefulness for the Japanese population is unclear. We examined and validated the staging system using hs-cTnT, eGFR, and B-type natriuretic peptide (BNP) in Japanese patients with ATTRwt-CM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>We retrospectively evaluated 176 patients with ATTRwt-CM. The cut-off values of hs-cTnT and eGFR were selected as 0.05 ng\/mL and 45 mL\/min\/1.73 m2, respectively, based on a previous report. The optimal cut-off value of BNP was 255.6 pg\/mL to predict all-cause mortality (sensitivity, 75%; specificity, 58%; area under the curve, 0.69; 95% confidence interval [CI], 0.61\u20130.78; P &amp;lt; 0.001) based on a receiver operating characteristic curve. We defined the cut-off value of BNP as 250 pg\/mL. Increased hs-cTnT (&amp;gt;0.05 ng\/mL) and BNP (&amp;gt;250 pg\/mL) and decreased eGFR (&amp;lt;45 mL\/min\/1.73 m2) were significant predictors of poor prognosis (P &amp;lt; 0.05). We calculated the score by adding 1 point if hs-cTnT and BNP levels increased or eGFR decreased by more than the cut-off value. The hazard ratio of all-cause death adjusted by age and sex, using score 0 as a reference, was 0.44 (95% CI 0.08\u20132.49, P = 0.44) for score 1, 3.69 (95% CI 1.21\u201311.21, P = 0.02) for score 2, and 5.40 (95% CI 1.57\u201318.54, P = 0.007) for score 3. We divided patients into a low score group (0\u20131 point) and high score group (2\u20133 points). Kaplan\u2013Meier analyses revealed significant differences in all-cause death and rehospitalization for heart failure (log rank test; P &amp;lt; 0.001), and after adjusting for sex and age, the hazard ratio of all-cause death was 6.96 (95% Cl 2.88\u201316.83, P &amp;lt; 0.001) and that for rehospitalization for heart failure was 4.27 (95% Cl 2.26\u20138.07, P &amp;lt; 0.001) in the high-risk group, compared with those in the low-risk group. The median survival period was 32.0 months in the high-risk group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This simple staging system, which combines hs-cTnT, BNP, and eGFR, was useful for predicting prognosis in Japanese patients with ATTRwt-CM. This system can objectively evaluate the disease progression of ATTRwt-CM and may be useful for patient selection for disease-modifying therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13847","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T04:41:46Z","timestamp":1645504906000},"page":"1731-1739","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A Simple Staging System Using Biomarkers for Wild-Type Transthyretin Amyloid Cardiomyopathy in Japan"],"prefix":"10.1093","volume":"9","author":[{"given":"Naoya","family":"Nakashima","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University , 1-1-1 Honjo, Chou-ku, Kumamoto, 860-8556 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,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University , 1-1-1 Honjo, Chou-ku, Kumamoto, 860-8556 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Hirakawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University , 1-1-1 Honjo, Chou-ku, Kumamoto, 860-8556 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanobu","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University , 1-1-1 Honjo, Chou-ku, Kumamoto, 860-8556 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Tabata","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University , 1-1-1 Honjo, Chou-ku, Kumamoto, 860-8556 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenshi","family":"Yamanaga","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University , 1-1-1 Honjo, Chou-ku, Kumamoto, 860-8556 ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Fujisue","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University , 1-1-1 Honjo, Chou-ku, Kumamoto, 860-8556 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