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This study aimed to illuminate the relationship between RVP proportion and LVEF, as well as disclosing independent predictors of RVP dependence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Patients indicated for permanent pacemaker implantation were included (2016\u20132020). The ventricular pacing lead was placed in right ventricular apex or septum. Pacing mode programming followed universal standard. Electrocardiographic, echocardiographic, and serological parameters were collected. RVP dependence was defined according to its influence on LVEF. This study was of case\u2013control design. Included patients were matched by potentially confounding factors through propensity score matching. A total of 1183 patients were included, and the mean duration of follow-up was 24 months. Percentage of RVP &amp;lt; 80% hardly influenced LVEF; however, LVEF tended to decrease with higher RVP proportion. High degree\/complete atrioventricular block (AVB) [odds ratio (OR) = 5.71, 95% confidence interval (CI): 3.66\u20138.85], atrial fibrillation (AF) (OR = 2.04, 95% CI: 1.47\u20132.82), percutaneous coronary intervention (PCI) (OR = 2.89, 95% CI: 1.24\u20136.76), maximum heart rate (HRmax) &amp;lt; 110 b.p.m. (OR = 2.74, 95% CI: 1.58\u20134.76), QRS duration &amp;gt; 120 ms (OR = 2.46, 95% CI: 1.42\u20134.27), QTc interval &amp;gt; 470 ms (OR = 2.01, 95% CI: 1.33\u20133.05), and pulmonary artery systolic pressure (PASP) &amp;gt; 40 mmHg (OR = 1.93, 95% CI: 1.46\u20132.56) were proved to predict RVP dependence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>High RVP percentage (&amp;gt;80%) indicating RVP dependence significantly correlates with poor prognosis of cardiac function. High degree\/complete AVB, AF, ischaemic aetiology, PCI history, HRmax &amp;lt; 110 b.p.m., QRS duration &amp;gt; 120 ms, QTc interval &amp;gt; 470 ms, and PASP &amp;gt; 40 mmHg were verified as independent risk factors of RVP dependence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13918","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T02:47:29Z","timestamp":1651027649000},"page":"2325-2335","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Risk Factors of Pacing Dependence and Cardiac Dysfunction in Patients with Permanent Pacemaker Implantation"],"prefix":"10.1093","volume":"9","author":[{"given":"Ziqing","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University , 180 Fenglin Road, Shanghai, 200032 ,","place":["China"]},{"name":"National Clinical Research Center for Interventional Medicine , Shanghai ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixiu","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University , 180 Fenglin Road, Shanghai, 200032 ,","place":["China"]},{"name":"National Clinical Research Center for Interventional Medicine , Shanghai ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zilong","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University , 180 Fenglin Road, Shanghai, 200032 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yucheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University , 180 Fenglin Road, Shanghai, 200032 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University , 180 Fenglin Road, Shanghai, 200032 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University , 180 Fenglin Road, Shanghai, 200032 ,","place":["China"]},{"name":"National Clinical Research Center for Interventional Medicine , Shanghai ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enyong","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University , 180 Fenglin Road, Shanghai, 200032 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University , 180 Fenglin Road, Shanghai, 200032 ,","place":["China"]},{"name":"National Clinical Research Center for Interventional Medicine , Shanghai ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueying","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University , 180 Fenglin Road, Shanghai, 200032 ,","place":["China"]},{"name":"National Clinical Research Center for Interventional Medicine , Shanghai ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengmei","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University , 180 Fenglin Road, Shanghai, 200032 ,","place":["China"]},{"name":"National Clinical Research Center for Interventional Medicine , Shanghai ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruizhen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University , 180 Fenglin Road, Shanghai, 200032 ,","place":["China"]},{"name":"Department of Cardiovascular Diseases, Key Laboratory of Viral Heart Diseases, Ministry of Public Health, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University , Shanghai 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