{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T09:12:32Z","timestamp":1790759552801,"version":"4.1.0"},"reference-count":122,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":1327,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T00:00:00Z","timestamp":1650240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Adverse remodelling following an initial insult is the hallmark of heart failure (HF) development and progression. It is manifested as changes in size, shape, and function of the myocardium. While cardiac remodelling may be compensatory in the short term, further neurohumoral activation and haemodynamic overload drive this deleterious process that is associated with impaired prognosis. However, in some patients, the changes may be reversed. Left ventricular reverse remodelling (LVRR) is characterized as a decrease in chamber volume and normalization of shape associated with improvement in both systolic and diastolic function. LVRR might occur spontaneously or more often in response to therapeutic interventions that either remove the initial stressor or alleviate some of the mechanisms that contribute to further deterioration of the failing heart. Although the process of LVRR in patients with new-onset HF may take up to 2 years after initiating treatment, there is a significant portion of patients who do not improve despite optimal therapy, which has serious clinical implications when considering treatment escalation towards more aggressive options. On the contrary, in patients that achieve delayed improvement in cardiac function and architecture, waiting might avoid untimely implantable cardioverter-defibrillator implantation. Therefore, prognostication of successful LVRR based on clinical, imaging, and biomarker predictors is of utmost importance. LVRR has a positive impact on prognosis. However, reverse remodelled hearts continue to have abnormal features. In fact, most of the molecular, cellular, interstitial, and genome expression abnormalities remain and a susceptibility to dysfunction redevelopment under biomechanical stress persists in most patients. Hence, a distinction should be made between reverse remodelling and true myocardial recovery. In this comprehensive review, current evidence on LVRR, its predictors, and implications on prognostication, with a specific focus on HF patients with non-ischaemic cardiomyopathy, as well as on novel drugs, is presented.<\/jats:p>","DOI":"10.1002\/ehf2.13939","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T01:13:40Z","timestamp":1650330820000},"page":"2070-2083","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Left Ventricular Reverse Remodelling and Its Predictors in Non-Ischaemic Cardiomyopathy"],"prefix":"10.1093","volume":"9","author":[{"given":"Tomas","family":"Hnat","sequence":"first","affiliation":[{"name":"Department of Cardiology, 2nd Faculty of Medicine, Charles University and University Hospital Motol , V \u00davalu 84\/1, Prague, 15006 ,","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Veselka","sequence":"additional","affiliation":[{"name":"Department of Cardiology, 2nd Faculty of Medicine, Charles University and University Hospital Motol , V \u00davalu 84\/1, Prague, 15006 ,","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Honek","sequence":"additional","affiliation":[{"name":"Department of Cardiology, 2nd Faculty of Medicine, Charles University and University Hospital Motol , V \u00davalu 84\/1, Prague, 15006 ,","place":["Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,18]]},"reference":[{"key":"2026012114142906600_ehf213939-bib-0001","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0735-1097(99)00630-0","article-title":"Cardiac remodeling\u2014concepts and clinical implications: a consensus paper from an International Forum on Cardiac Remodeling","volume":"35","author":"Cohn","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"2026012114142906600_ehf213939-bib-0002","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1161\/01.CIR.81.4.1161","article-title":"Ventricular remodeling after myocardial infarction: experimental observations and clinical implications","volume":"81","author":"Pfeffer","year":"1990","journal-title":"Circulation"},{"key":"2026012114142906600_ehf213939-bib-0003","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0167-5273(98)00362-3","article-title":"Left ventricular remodelling: common process in patients with different primary myocardial disorders","volume":"68","author":"Florea","year":"1999","journal-title":"Int J Cardiol"},{"key":"2026012114142906600_ehf213939-bib-0004","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1161\/01.CIR.91.9.2314","article-title":"Reverse remodeling from cardiomyoplasty in human heart failure: external constraint versus active assist","volume":"91","author":"Kass","year":"1995","journal-title":"Circulation"},{"key":"2026012114142906600_ehf213939-bib-0005","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/j.jacc.2010.11.030","article-title":"Prevalence and prognostic significance of left ventricular reverse remodeling in dilated cardiomyopathy receiving tailored medical treatment","volume":"57","author":"Merlo","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"2026012114142906600_ehf213939-bib-0006","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1161\/CIRCULATIONAHA.107.743120","article-title":"Results of the predictors of response to CRT (PROSPECT) trial","volume":"117","author":"Chung","year":"2008","journal-title":"Circulation"},{"key":"2026012114142906600_ehf213939-bib-0007","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ahj.2011.10.001","article-title":"Factors associated with improvement in ejection fraction in clinical practice among patients with heart failure: findings from IMPROVE HF","volume":"163","author":"Wilcox","year":"2012","journal-title":"Am Heart J"},{"key":"2026012114142906600_ehf213939-bib-0008","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1161\/CIRCHEARTFAILURE.113.000929","article-title":"Predictors of spontaneous reverse remodeling in mild heart failure patients with left ventricular dysfunction","volume":"7","author":"Brenyo","year":"2014","journal-title":"Circ Hear Fail"},{"key":"2026012114142906600_ehf213939-bib-0009","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1161\/CIRCIMAGING.113.000438","article-title":"Myocardial fibrosis as a key determinant of left ventricular remodeling in idiopathic dilated cardiomyopathy: a contrast-enhanced cardiovascular magnetic study","volume":"6","author":"Masci","year":"2013","journal-title":"Circ Cardiovasc Imaging"},{"key":"2026012114142906600_ehf213939-bib-0010","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jacc.2012.07.072","article-title":"Novel predictors of left ventricular reverse remodeling in individuals with recent-onset dilated cardiomyopathy","volume":"61","author":"Kubanek","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"2026012114142906600_ehf213939-bib-0011","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nrcardio.2017.139","article-title":"Reverse remodelling and myocardial recovery in heart failure","volume":"15","author":"Kim","year":"2018","journal-title":"Nat Rev Cardiol"},{"key":"2026012114142906600_ehf213939-bib-0012","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1161\/hc3101.093903","article-title":"Comparison of right and left ventricular responses to left ventricular assist device support in patients with severe heart failure","volume":"104","author":"Barbone","year":"2001","journal-title":"Circulation"},{"key":"2026012114142906600_ehf213939-bib-0013","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.jacc.2004.11.042","article-title":"Left ventricular assist device support normalizes left and right ventricular beta-adrenergic pathway properties","volume":"45","author":"Klotz","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"2026012114142906600_ehf213939-bib-0014","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1161\/01.RES.0000159390.03503.c3","article-title":"Mixed messages: transcription patterns in failing and recovering human myocardium","volume":"96","author":"Margulies","year":"2005","journal-title":"Circ Res"},{"key":"2026012114142906600_ehf213939-bib-0015","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ahj.2007.08.010","article-title":"Recovery of normal ventricular function in patients with dilated cardiomyopathy: predictors of an increasingly prevalent clinical event","volume":"155","author":"Binkley","year":"2008","journal-title":"Am Heart J"},{"key":"2026012114142906600_ehf213939-bib-0016","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1161\/CIRCULATIONAHA.113.003863","article-title":"Deep RNA sequencing reveals dynamic regulation of myocardial noncoding RNAs in failing human heart and remodeling with mechanical circulatory support","volume":"129","author":"Yang","year":"2014","journal-title":"Circulation"},{"key":"2026012114142906600_ehf213939-bib-0017","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1016\/j.jacc.2012.06.062","article-title":"Myocardial recovery and the failing heart: myth, magic, or molecular target?","volume":"60","author":"Mann","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"2026012114142906600_ehf213939-bib-0018","first-page":"9","article-title":"Myocardial recovery in patients receiving contemporary left ventricular assist devices","volume":"9","author":"Topkara","year":"2016","journal-title":"Circ Hear Fail"},{"key":"2026012114142906600_ehf213939-bib-0019","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/S0003-4975(99)00542-1","article-title":"Cardiac recovery in dilated cardiomyopathy by unloading with a left ventricular assist device","volume":"68","author":"Hetzer","year":"1999","journal-title":"Ann Thorac Surg"},{"key":"2026012114142906600_ehf213939-bib-0020","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/ejhf.592","article-title":"ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution","volume":"18","author":"Ponikowski","year":"2016","journal-title":"Eur J Heart Fail 2016"},{"key":"2026012114142906600_ehf213939-bib-0021","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/CRD.0000000000000068","article-title":"Reverse remodeling in systolic heart failure","volume":"23","author":"Saraon","year":"2015","journal-title":"Cardiol Rev"},{"key":"2026012114142906600_ehf213939-bib-0022","doi-asserted-by":"crossref","first-page":"D66","DOI":"10.1016\/j.ehjsup.2004.05.019","article-title":"Reverse remodeling in heart failure\u2014fact or fiction?","volume":"6","author":"Pieske","year":"2004","journal-title":"Eur Heart Journal, Suppl"},{"key":"2026012114142906600_ehf213939-bib-0023","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1755-5922.2010.00247.x","article-title":"Myocardial reverse remodeling","volume":"30","author":"Hellawell","year":"2012","journal-title":"Cardiovasc Ther"},{"key":"2026012114142906600_ehf213939-bib-0024","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jacc.2010.05.011","article-title":"Quantitative evaluation of drug or device effects on ventricular remodeling as predictors of therapeutic effects on mortality in patients with heart failure and reduced ejection fraction: a meta-analytic approach","volume":"56","author":"Kramer","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"2026012114142906600_ehf213939-bib-0025","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/S0002-8703(99)70083-9","article-title":"Metoprolol CR\/XL in patients with heart failure: a pilot study examining the tolerability, safety, and effect on left ventricular ejection fraction","volume":"138","author":"Goldstein","year":"1999","journal-title":"Am Heart J"},{"key":"2026012114142906600_ehf213939-bib-0026","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1016\/S0735-1097(00)01006-8","article-title":"Antiremodeling effects on the left ventricle during beta-blockade with metoprolol in the treatment of chronic heart failure","volume":"36","author":"Groenning","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"2026012114142906600_ehf213939-bib-0027","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1161\/01.CIR.101.4.378","article-title":"Effects of metoprolol CR in patients with ischemic and dilated cardiomyopathy: the randomized evaluation of strategies for left ventricular dysfunction pilot study","volume":"101","author":"White","year":"2000","journal-title":"Circulation"},{"key":"2026012114142906600_ehf213939-bib-0028","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1161\/CIRCULATIONAHA.106.666016","article-title":"Metoprolol reverses left ventricular remodeling in patients with asymptomatic systolic dysfunction: the REversal of VEntricular remodeling with Toprol-XL (REVERT) trial","volume":"116","author":"Colucci","year":"2007","journal-title":"Circulation"},{"key":"2026012114142906600_ehf213939-bib-0029","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S1388-9842(02)00114-9","article-title":"Effects of carvedilol on left ventricular remodeling and systolic function in elderly patients with heart failure","volume":"4","author":"Palazzuoli","year":"2002","journal-title":"Eur J Heart Fail"},{"key":"2026012114142906600_ehf213939-bib-0030","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1161\/01.CIR.94.11.2793","article-title":"Double-blind, placebo-controlled study of the effects of carvedilol in patients with moderate to severe heart failure: the PRECISE trial. Prospective Randomized Evaluation of Carvedilol on Symptoms and Exercise","volume":"94","author":"Packer","year":"1996","journal-title":"Circulation"},{"key":"2026012114142906600_ehf213939-bib-0031","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1161\/01.CIR.94.11.2807","article-title":"Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure. MOCHA Investigators","volume":"94","author":"Bristow","year":"1996","journal-title":"Circulation"},{"key":"2026012114142906600_ehf213939-bib-0032","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1161\/01.CIR.96.7.2197","article-title":"Prognostic value of bisoprolol-induced hemodynamic effects in heart failure during the Cardiac Insufficiency Bisoprolol Study (CIBIS)","volume":"96","author":"L\u00e9ch\u00e2t","year":"1997","journal-title":"Circulation"},{"key":"2026012114142906600_ehf213939-bib-0033","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1067\/mhj.2002.121269","article-title":"Effects of bisoprolol fumarate on left ventricular size, function, and exercise capacity in patients with heart failure: analysis with magnetic resonance myocardial tagging","volume":"143","author":"Dubach","year":"2002","journal-title":"Am Heart J"},{"key":"2026012114142906600_ehf213939-bib-0034","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/0735-1097(94)00543-Y","article-title":"Time course of improvement in left ventricular function, mass and geometry in patients with congestive heart failure treated with beta-adrenergic blockade","volume":"25","author":"Hall","year":"1995","journal-title":"J Am Coll Cardiol"},{"key":"2026012114142906600_ehf213939-bib-0035","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1161\/01.CIR.98.12.1184","article-title":"Clinical effects of beta-adrenergic blockade in chronic heart failure: a meta-analysis of double-blind, placebo-controlled, randomized trials","volume":"98","author":"Lechat","year":"1998","journal-title":"Circulation"},{"key":"2026012114142906600_ehf213939-bib-0036","first-page":"67","article-title":"Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure","volume":"115","author":"Yusuf","year":"1991","journal-title":"Ann Intern Med"},{"key":"2026012114142906600_ehf213939-bib-0037","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1161\/01.CIR.91.10.2573","article-title":"Effects of long-term enalapril therapy on cardiac structure and function in patients with left ventricular dysfunction results of the SOLVD echocardiography substudy","volume":"91","author":"Greenberg","year":"1995","journal-title":"Circulation"},{"key":"2026012114142906600_ehf213939-bib-0038","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1161\/01.CIR.86.2.431","article-title":"Effects of the angiotensin converting enzyme inhibitor enalapril on the long-term progression of left ventricular dysfunction in patients with heart failure","volume":"86","author":"Konstam","year":"1992","journal-title":"Circulation"},{"key":"2026012114142906600_ehf213939-bib-0039","first-page":"90","article-title":"One-year clinical and echocardiographic follow-up of patients with congestive cardiomyopathy treated with captopril compared to placebo","volume":"30","author":"Keren","year":"1994","journal-title":"Isr J Med Sci"},{"key":"2026012114142906600_ehf213939-bib-0040","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1067\/mhj.2001.116768","article-title":"Regression of left ventricular remodeling in chronic heart failure: comparative and combined effects of captopril and carvedilol","volume":"142","author":"Khattar","year":"2001","journal-title":"Am Heart J"},{"key":"2026012114142906600_ehf213939-bib-0041","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/S0735-1097(02)02063-6","article-title":"Valsartan benefits left ventricular structure and function in heart failure: Val-HeFT echocardiographic study","volume":"40","author":"Wong","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"2026012114142906600_ehf213939-bib-0042","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S1388-9842(03)00162-4","article-title":"Efficacy and safety of oral candesartan cilexetil in patients with congestive heart failure","volume":"5","author":"Matsumori","year":"2003","journal-title":"Eur J Heart Fail"},{"key":"2026012114142906600_ehf213939-bib-0043","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/S0735-1097(01)01116-0","article-title":"Effect of spironolactone on plasma brain natriuretic peptide and left ventricular remodeling in patients with congestive heart failure","volume":"37","author":"Tsutamoto","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"2026012114142906600_ehf213939-bib-0044","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S0735-1097(02)01965-4","article-title":"Long-term, dose-dependent effects of spironolactone on left ventricular function and exercise tolerance in patients with chronic heart failure","volume":"40","author":"Cicoira","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"2026012114142906600_ehf213939-bib-0045","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.jacc.2007.03.062","article-title":"Aldosterone receptor antagonism induces reverse remodeling when added to angiotensin receptor blockade in chronic heart failure","volume":"50","author":"Chan","year":"2007","journal-title":"J Am Coll Cardiol"},{"key":"2026012114142906600_ehf213939-bib-0046","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1161\/CIRCHEARTFAILURE.109.906909","article-title":"Randomized, double-blind, multicenter, placebo-controlled study evaluating the effect of aldosterone antagonism with eplerenone on ventricular remodeling in patients with mild-to-moderate heart failure and left ventricular systolic dysfunction","volume":"3","author":"Udelson","year":"2010","journal-title":"Circ Hear Fail"},{"key":"2026012114142906600_ehf213939-bib-0047","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1161\/CIRCHEARTFAILURE.112.000074","article-title":"Impact of mineralocorticoid receptor antagonists on changes in cardiac structure and function of left ventricular dysfunction a meta-analysis of randomized controlled trials","volume":"6","author":"Li","year":"2013","journal-title":"Circ Hear Fail"},{"key":"2026012114142906600_ehf213939-bib-0048","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1056\/NEJMoa1911303","article-title":"Dapagliflozin in patients with heart failure and reduced ejection fraction","volume":"381","author":"McMurray","year":"2019","journal-title":"N Engl J Med"},{"key":"2026012114142906600_ehf213939-bib-0049","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/1755-5922.12435","article-title":"The reverse remodeling response to sacubitril\/valsartan therapy in heart failure with reduced ejection fraction","volume":"36","author":"Martens","year":"2018","journal-title":"Cardiovasc Ther"},{"key":"2026012114142906600_ehf213939-bib-0050","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1001\/jama.2019.12821","article-title":"Association of change in n-terminal pro-b-type natriuretic peptide following initiation of sacubitril-valsartan treatment with cardiac structure and function in patients with heart failure with reduced ejection fraction","volume":"322","author":"Januzzi","year":"2019","journal-title":"JAMA - J Am Med Assoc"},{"key":"2026012114142906600_ehf213939-bib-0051","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1002\/ehf2.13285","article-title":"Reverse remodelling by sacubitril\/valsartan predicts the prognosis in heart failure with reduced ejection fraction","volume":"8","author":"Moon","year":"2021","journal-title":"ESC Hear Fail"},{"key":"2026012114142906600_ehf213939-bib-0052","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1161\/CIRCULATIONAHA.118.037077","article-title":"Angiotensin receptor neprilysin inhibitor for functional mitral regurgitation: PRIME study","volume":"139","author":"Kang","year":"2019","journal-title":"Circulation"},{"key":"2026012114142906600_ehf213939-bib-0053","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0140-6736(18)32590-X","article-title":"SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials","volume":"393","author":"Zelniker","year":"2019","journal-title":"Lancet"},{"key":"2026012114142906600_ehf213939-bib-0054","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1056\/NEJMoa2022190","article-title":"Cardiovascular and renal outcomes with empagliflozin in heart failure","volume":"383","author":"Packer","year":"2020","journal-title":"N Engl J Med"},{"key":"2026012114142906600_ehf213939-bib-0055","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.2337\/dc19-2187","article-title":"Dapagliflozin versus placebo on left ventricular remodeling in patients with diabetes and heart failure: the Reform trial","volume":"43","author":"Singh","year":"2020","journal-title":"Diabetes Care"},{"key":"2026012114142906600_ehf213939-bib-0056","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1161\/CIRCULATIONAHA.120.052186","article-title":"Effect of empagliflozin on left ventricular volumes in patients with type 2 diabetes, or prediabetes, and heart failure with reduced ejection fraction (SUGAR-DM-HF)","volume":"143","author":"Lee","year":"2021","journal-title":"Circulation"},{"key":"2026012114142906600_ehf213939-bib-0057","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1093\/europace\/euu016","article-title":"New-onset left bundle branch block independently predicts long-term mortality in patients with idiopathic dilated cardiomyopathy: data from the Trieste Heart Muscle Disease Registry","volume":"16","author":"Aleksova","year":"2014","journal-title":"Europace"},{"key":"2026012114142906600_ehf213939-bib-0058","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.jchf.2016.07.002","article-title":"Outcomes with left bundle branch block and mildly to moderately reduced left ventricular function","volume":"4","author":"Witt","year":"2016","journal-title":"JACC Hear Fail"},{"key":"2026012114142906600_ehf213939-bib-0059","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/eurheartj\/ehs305","article-title":"Prevalence, correlates, and prognostic significance of QRS prolongation in heart failure with reduced and preserved ejection fraction","volume":"34","author":"Lund","year":"2013","journal-title":"Eur Heart J"},{"key":"2026012114142906600_ehf213939-bib-0060","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.jacc.2017.11.020","article-title":"Impaired recovery of left ventricular function in patients with cardiomyopathy and left bundle branch block","volume":"71","author":"Sze","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2026012114142906600_ehf213939-bib-0061","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1056\/NEJMoa032423","article-title":"Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure","volume":"350","author":"Bristow","year":"2004","journal-title":"N Engl J Med"},{"key":"2026012114142906600_ehf213939-bib-0062","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1056\/NEJMoa0906431","article-title":"Cardiac-resynchronization therapy for the prevention of heart-failure events","volume":"361","author":"Moss","year":"2009","journal-title":"N Engl J Med"},{"key":"2026012114142906600_ehf213939-bib-0063","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/S0195-668X(02)00475-X","article-title":"Left ventricular remodelling and haemodynamic effects of multisite biventricular pacing in patients with left ventricular systolic dysfunction and activation disturbances in sinus rhythm: sub-study of the MUSTIC (Multisite Stimulation in Cardiomyopathies) trial","volume":"24","author":"Duncan","year":"2003","journal-title":"Eur Heart J"},{"key":"2026012114142906600_ehf213939-bib-0064","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1161\/CIRCULATIONAHA.108.818724","article-title":"Cardiac resynchronization induces major structural and functional reverse remodeling in patients with New York Heart Association class I\/II heart failure","volume":"120","author":"St. John Sutton","year":"2009","journal-title":"Circulation"},{"key":"2026012114142906600_ehf213939-bib-0065","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1136\/hrt.2005.067967","article-title":"Reverse remodelling in heart failure with cardiac resynchronisation therapy","volume":"93","author":"Sutton","year":"2007","journal-title":"Heart"},{"key":"2026012114142906600_ehf213939-bib-0066","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1161\/01.CIR.0000065226.24159.E9","article-title":"Effect of cardiac resynchronization therapy on left ventricular size and function in chronic heart failure","volume":"107","author":"St. John Sutton","year":"2003","journal-title":"Circulation"},{"key":"2026012114142906600_ehf213939-bib-0067","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1016\/j.jacc.2010.01.022","article-title":"Long-term reverse remodeling with cardiac resynchronization therapy. Results of extended echocardiographic follow-up","volume":"55","author":"Verhaert","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"2026012114142906600_ehf213939-bib-0068","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.1093\/eurheartj\/eht160","article-title":"Long-term impact of cardiac resynchronization therapy in mild heart failure: 5-year results from the REsynchronization reVErses Remodeling in Systolic left vEntricular dysfunction (REVERSE) study","volume":"34","author":"Linde","year":"2013","journal-title":"Eur Heart J"},{"key":"2026012114142906600_ehf213939-bib-0069","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1136\/hrt.2011.225789","article-title":"Independent prognostic value of functional mitral regurgitation in patients with heart failure. A quantitative analysis of 1256 patients with ischaemic and non-ischaemic dilated cardiomyopathy","volume":"97","author":"Rossi","year":"2011","journal-title":"Heart"},{"key":"2026012114142906600_ehf213939-bib-0070","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jcmg.2018.11.006","article-title":"Proportionate and disproportionate functional mitral regurgitation: a new conceptual framework that reconciles the results of the MITRA-FR and COAPT trials","volume":"12","author":"Grayburn","year":"2019","journal-title":"JACC Cardiovasc Imaging"},{"key":"2026012114142906600_ehf213939-bib-0071","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.athoracsur.2007.11.021","article-title":"Recurrence of mitral regurgitation parallels the absence of left ventricular reverse remodeling after mitral repair in advanced dilated cardiomyopathy","volume":"85","author":"De","year":"2008","journal-title":"Ann Thorac Surg"},{"key":"2026012114142906600_ehf213939-bib-0072","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1056\/NEJMoa1806640","article-title":"Transcatheter mitral-valve repair in patients with heart failure","volume":"379","author":"Stone","year":"2018","journal-title":"N Engl J Med"},{"key":"2026012114142906600_ehf213939-bib-0073","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1056\/NEJMoa1805374","article-title":"Percutaneous repair or medical treatment for secondary mitral regurgitation","volume":"379","author":"Obadia","year":"2018","journal-title":"N Engl J Med"},{"key":"2026012114142906600_ehf213939-bib-0074","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.echo.2016.06.009","article-title":"Three-dimensional transthoracic echocardiography in the comprehensive evaluation of right and left heart chamber remodeling following percutaneous mitral valve repair","volume":"29","author":"Gripari","year":"2016","journal-title":"J Am Soc Echocardiogr"},{"key":"2026012114142906600_ehf213939-bib-0075","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1002\/ehf2.12750","article-title":"MitraClip and left ventricular reverse remodelling: a strain imaging study","volume":"7","author":"Papadopoulos","year":"2020","journal-title":"ESC Hear Fail"},{"key":"2026012114142906600_ehf213939-bib-0076","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1080\/24748706.2018.1516912","article-title":"Impact of transcatheter mitral valve repair on left ventricular remodeling in secondary mitral regurgitation: a meta-analysis","volume":"2","author":"Megaly","year":"2018","journal-title":"Struct Hear"},{"key":"2026012114142906600_ehf213939-bib-0077","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/ejhf.1343","article-title":"Left ventricular reverse remodelling predicts long-term outcomes in patients with functional mitral regurgitation undergoing MitraClip therapy: results from a multicentre registry","volume":"21","author":"Adamo","year":"2019","journal-title":"Eur J Heart Fail"},{"key":"2026012114142906600_ehf213939-bib-0078","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1080\/14779072.2018.1533815","article-title":"Left ventricular reverse remodeling prediction in non-ischemic cardiomyopathy: present and perspectives","volume":"16","author":"Mas\u00e8","year":"2018","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"2026012114142906600_ehf213939-bib-0079","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S1388-9842(00)00150-1","article-title":"Frequency, prognosis and predictors of improvement of systolic left ventricular function in patients with \u2018classical\u2019 clinical diagnosis of idiopathic dilated cardiomyopathy","volume":"3","author":"Cicoira","year":"2001","journal-title":"Eur J Heart Fail"},{"key":"2026012114142906600_ehf213939-bib-0080","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1253\/circj.CJ-12-0507","article-title":"Predictors of left ventricular reverse remodeling and subsequent outcome in nonischemic dilated cardiomyopathy","volume":"77","author":"Choi","year":"2013","journal-title":"Circ J"},{"key":"2026012114142906600_ehf213939-bib-0081","doi-asserted-by":"crossref","first-page":"465","DOI":"10.2459\/JCM.0000000000000679","article-title":"Predictors of left ventricular reverse remodeling in patients with chronic heart failure","volume":"19","author":"D'Auria","year":"2018","journal-title":"J Cardiovasc Med"},{"key":"2026012114142906600_ehf213939-bib-0082","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/ejhf.1103","article-title":"Evolving concepts in dilated cardiomyopathy","volume":"20","author":"Merlo","year":"2018","journal-title":"Eur J Heart Fail"},{"key":"2026012114142906600_ehf213939-bib-0083","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.jchf.2017.07.011","article-title":"Effect of sex on reverse remodeling in chronic systolic heart failure","volume":"5","author":"Aimo","year":"2017","journal-title":"JACC Hear Fail"},{"key":"2026012114142906600_ehf213939-bib-0084","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1136\/heartjnl-2016-311017","article-title":"Association between mutation status and left ventricular reverse remodelling in dilated cardiomyopathy","volume":"103","author":"Dal Ferro","year":"2017","journal-title":"Heart"},{"key":"2026012114142906600_ehf213939-bib-0085","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1161\/CIRCHEARTFAILURE.113.000929","article-title":"Predictors of spontaneous reverse remodeling in mild heart failure patients with left ventricular dysfunction","volume":"7","author":"Brenyo","year":"2014","journal-title":"Circ Heart Fail"},{"key":"2026012114142906600_ehf213939-bib-0086","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ijcard.2015.02.019","article-title":"Biomarker-assist score for reverse remodeling prediction in heart failure: the ST2-R2 score","volume":"184","author":"Lup\u00f3n","year":"2015","journal-title":"Int J Cardiol"},{"key":"2026012114142906600_ehf213939-bib-0087","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.repc.2015.11.014","article-title":"Prevalence, predictors and prognosis of ventricular reverse remodeling in idiopathic dilated cardiomyopathy","volume":"35","author":"Amorim","year":"2016","journal-title":"Rev Port Cardiol"},{"key":"2026012114142906600_ehf213939-bib-0088","doi-asserted-by":"crossref","first-page":"iii73","DOI":"10.1093\/europace\/eun219","article-title":"Predicting response to CRT. The value of two- and three-dimensional echocardiography","volume":"10","author":"Marsan","year":"2008","journal-title":"Europace"},{"key":"2026012114142906600_ehf213939-bib-0089","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1093\/eurjhf\/hfr073","article-title":"Multicentre study using strain delay index for predicting response to cardiac resynchronization therapy (MUSIC study)","volume":"13","author":"Lim","year":"2011","journal-title":"Eur J Heart Fail"},{"key":"2026012114142906600_ehf213939-bib-0090","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ijcard.2017.10.043","article-title":"Late gadolinium enhancement as a predictor of functional recovery, need for defibrillator implantation and prognosis in non-ischemic dilated cardiomyopathy","volume":"250","author":"Barison","year":"2018","journal-title":"Int J Cardiol"},{"key":"2026012114142906600_ehf213939-bib-0091","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/jce.12855","article-title":"Focal but not diffuse myocardial fibrosis burden quantification using cardiac magnetic resonance imaging predicts left ventricular reverse modeling following cardiac resynchronization therapy","volume":"27","author":"Chen","year":"2016","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2026012114142906600_ehf213939-bib-0092","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1016\/j.jacc.2011.03.072","article-title":"Use of amino-terminal ProB-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction","volume":"58","author":"Januzzi","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"2026012114142906600_ehf213939-bib-0093","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jchf.2018.10.014","article-title":"NT-proBNP goal achievement is associated with significant reverse remodeling and improved clinical outcomes in HFrEF","volume":"7","author":"Daubert","year":"2019","journal-title":"JACC Hear Fail"},{"key":"2026012114142906600_ehf213939-bib-0094","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ijcard.2015.11.163","article-title":"Prediction of survival and magnitude of reverse remodeling using the ST2-R2 score in heart failure: a multicenter study","volume":"204","author":"Lup\u00f3n","year":"2016","journal-title":"Int J Cardiol"},{"key":"2026012114142906600_ehf213939-bib-0095","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.jacc.2018.05.042","article-title":"Dynamic trajectories of left ventricular ejection fraction in heart failure","volume":"72","author":"Lup\u00f3n","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"2026012114142906600_ehf213939-bib-0096","doi-asserted-by":"crossref","first-page":"699","DOI":"10.2459\/JCM.0b013e32832bba35","article-title":"Natural history of dilated cardiomyopathy: from asymptomatic left ventricular dysfunction to heart failure\u2014a subgroup analysis from the Trieste Cardiomyopathy Registry","volume":"10","author":"Aleksova","year":"2009","journal-title":"J Cardiovasc Med"},{"key":"2026012114142906600_ehf213939-bib-0097","first-page":"9","article-title":"Heart failure with improved ejection fraction: clinical characteristics, correlates of recovery, and survival","volume":"9","author":"Florea","year":"2016","journal-title":"Circ Hear Fail"},{"key":"2026012114142906600_ehf213939-bib-0098","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1161\/CIRCULATIONAHA.113.006855","article-title":"Heart failure with recovered ejection fraction","volume":"129","author":"Basuray","year":"2014","journal-title":"Circulation"},{"key":"2026012114142906600_ehf213939-bib-0099","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jacc.2020.05.075","article-title":"Heart failure with recovered left ventricular ejection fraction: JACC Scientific Expert Panel","volume":"76","author":"Wilcox","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"2026012114142906600_ehf213939-bib-0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/JAHA.116.004512","article-title":"Avoiding untimely implantable cardioverter\/defibrillator implantation by intensified heart failure therapy optimization supported by the wearable cardioverter\/defibrillator\u2014the PROLONG study","volume":"6","author":"Duncker","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"2026012114142906600_ehf213939-bib-0101","first-page":"1","article-title":"Waiting period before implantable cardioverter-defibrillator implantation in newly diagnosed heart failure with reduced ejection fraction: a window of opportunity","volume":"10","author":"DeFilippis","year":"2017","journal-title":"Circ Hear Fail"},{"key":"2026012114142906600_ehf213939-bib-0102","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0140-6736(18)32484-X","article-title":"Withdrawal of pharmacological treatment for heart failure in patients with recovered dilated cardiomyopathy (TRED-HF): an open-label, pilot, randomised trial","volume":"393","author":"Halliday","year":"2019","journal-title":"Lancet"},{"key":"2026012114142906600_ehf213939-bib-0103","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1093\/europace\/euv129","article-title":"Mid-term clinical and echocardiographic evaluation of super responders with and without pacing: the preliminary results of a prospective, randomized, single-centre study","volume":"18","author":"Cay","year":"2016","journal-title":"Europace"},{"key":"2026012114142906600_ehf213939-bib-0104","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1161\/01.RES.44.4.503","article-title":"Myocardial infarct size and ventricular function in rats","volume":"44","author":"Pfeffer","year":"1979","journal-title":"Circ Res"},{"key":"2026012114142906600_ehf213939-bib-0105","first-page":"H1812","article-title":"Ventricular remodeling in a mouse model of myocardial infarction","volume":"274","author":"Patten","year":"1998","journal-title":"Am J Physiol"},{"key":"2026012114142906600_ehf213939-bib-0106","first-page":"H2147","article-title":"Myocardial ischemia and reperfusion: a murine model","volume":"269","author":"Michael","year":"1995","journal-title":"Am J Physiol"},{"key":"2026012114142906600_ehf213939-bib-0107","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1152\/japplphysiol.00691.2011","article-title":"Temporal pattern of left ventricular structural and functional remodeling following reversal of volume overload heart failure","volume":"111","author":"Hutchinson","year":"2011","journal-title":"J Appl Physiol (1985)"},{"key":"2026012114142906600_ehf213939-bib-0108","first-page":"1053","article-title":"Effects of epoxyeicosatrienoic acid-enhancing therapy on the course of congestive heart failure in angiotensin II-dependent rat hypertension: from mRNA analysis towards functional in vivo evaluation","volume":"9","author":"Kala","year":"2021","journal-title":"Biomedicine"},{"key":"2026012114142906600_ehf213939-bib-0109","doi-asserted-by":"crossref","first-page":"S432","DOI":"10.1054\/jcaf.2002.129284","article-title":"From mouse to man: understanding heart failure through genetically altered mouse models","volume":"8","author":"Chu","year":"2002","journal-title":"J Card Fail"},{"key":"2026012114142906600_ehf213939-bib-0110","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s12012-007-0022-4","article-title":"Long-term and short-term models for studying anthracycline cardiotoxicity and protectors","volume":"7","author":"Robert","year":"2007","journal-title":"Cardiovasc Toxicol"},{"key":"2026012114142906600_ehf213939-bib-0111","doi-asserted-by":"crossref","first-page":"9337","DOI":"10.3390\/ijms21249337","article-title":"Deleterious effects of hyperactivity of the renin-angiotensin system and hypertension on the course of chemotherapy-induced heart failure after doxorubicin administration: a study in Ren-2 transgenic rat","volume":"21","author":"Kala","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2026012114142906600_ehf213939-bib-0112","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1161\/01.RES.75.1.105","article-title":"Progressive ventricular remodeling in response to diffuse isoproterenol-induced myocardial necrosis in rats","volume":"75","author":"Teerlink","year":"1994","journal-title":"Circ Res"},{"key":"2026012114142906600_ehf213939-bib-0113","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1161\/01.CIR.91.1.176","article-title":"Effect of tachycardia heart failure on the restitution of left ventricular function in closed-chest dogs","volume":"91","author":"Prabhu","year":"1995","journal-title":"Circulation"},{"key":"2026012114142906600_ehf213939-bib-0114","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.healun.2010.01.010","article-title":"Reversal of impaired myocardial beta-adrenergic receptor signaling by continuous-flow left ventricular assist device support","volume":"29","author":"Akhter","year":"2010","journal-title":"J Heart Lung Transplant"},{"key":"2026012114142906600_ehf213939-bib-0115","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1161\/01.CIR.102.22.2713","article-title":"Chronic unloading by left ventricular assist device reverses contractile dysfunction and alters gene expression in end-stage heart failure","volume":"102","author":"Heerdt","year":"2000","journal-title":"Circulation"},{"key":"2026012114142906600_ehf213939-bib-0116","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/S0195-668X(03)00242-2","article-title":"Changes in sarcolemmal Ca entry and sarcoplasmic reticulum Ca content in ventricular myocytes from patients with end-stage heart failure following myocardial recovery after combined pharmacological and ventricular assist device therapy","volume":"24","author":"Terracciano","year":"2003","journal-title":"Eur Heart J"},{"key":"2026012114142906600_ehf213939-bib-0117","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1161\/01.CIR.98.7.656","article-title":"Regression of cellular hypertrophy after left ventricular assist device support","volume":"98","author":"Zafeiridis","year":"1998","journal-title":"Circulation"},{"key":"2026012114142906600_ehf213939-bib-0118","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1152\/physiolgenomics.00004.2004","article-title":"Genomic profiling of the human heart before and after mechanical support with a ventricular assist device reveals alterations in vascular signaling networks","volume":"17","author":"Hall","year":"2004","journal-title":"Physiol Genomics"},{"key":"2026012114142906600_ehf213939-bib-0119","doi-asserted-by":"crossref","first-page":"I57","DOI":"10.1161\/CIRCULATIONAHA.104.526137","article-title":"Gene profiling changes in cytoskeletal proteins during clinical recovery after left ventricular-assist device support","volume":"112","author":"Birks","year":"2005","journal-title":"Circulation"},{"key":"2026012114142906600_ehf213939-bib-0120","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s12265-009-9097-6","article-title":"A gene expression profile of the myocardial response to clenbuterol","volume":"2","author":"Lara-Pezzi","year":"2009","journal-title":"J Cardiovasc Transl Res"},{"key":"2026012114142906600_ehf213939-bib-0121","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1161\/CIRCULATIONAHA.108.813576","article-title":"Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support","volume":"119","author":"Matkovich","year":"2009","journal-title":"Circulation"},{"key":"2026012114142906600_ehf213939-bib-0122","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S1071-9164(99)91335-0","article-title":"Apoptosis, Bcl-2, and proliferating cell nuclear antigen in the failing human heart: observations made after implantation of left ventricular assist device","volume":"5","author":"Francis","year":"1999","journal-title":"J Card Fail"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ehf2.13939","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ehf2.13939","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/9\/4\/2070\/65349232\/eschf_9_4_2070.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/9\/4\/2070\/65349232\/eschf_9_4_2070.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T19:17:18Z","timestamp":1769023038000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/9\/4\/2070\/8322936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,18]]},"references-count":122,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,4,18]]},"published-print":{"date-parts":[[2022,8,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ehf2.13939","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,8]]},"published":{"date-parts":[[2022,4,18]]},"assertion":[{"value":"2021-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}