{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T14:20:39Z","timestamp":1771338039372,"version":"3.50.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":1317,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T00:00:00Z","timestamp":1651104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1C1C1014161"],"award-info":[{"award-number":["2020R1C1C1014161"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1C1C1014161"],"award-info":[{"award-number":["2020R1C1C1014161"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We evaluated the clinical outcomes and trajectory of cardiac reverse remodelling according to the timing of sacubitril\/valsartan (Sac\/Val) use in patients with heart failure (HF) with reduced ejection fraction (HFrEF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Patients with de novo HFrEF who used Sac\/Val between June 2017 and October 2019 were retrospectively enrolled. Patients were grouped into the earlier use group (initiation of Sac\/Val &amp;lt; 3 months after the first HFrEF diagnosis) and the later use group (initiation of Sac\/Val \u2265 3 months after the first HFrEF diagnosis). Primary outcome was a composite of HF hospitalization and cardiac death. Secondary outcomes were HF hospitalization, cardiac death, all-cause death, significant ventricular arrhythmia (ventricular tachycardia or ventricular fibrillation), and echocardiographic evidence of cardiac reverse remodelling including left ventricular ejection fraction (LVEF) change during follow-up. Among 115 enrolled patients, 67 were classified in the earlier use group, and 48 were classified in the later use group. Mean period of HFrEF diagnosis to Sac\/Val use was 52.1 \u00b1 14.3 days in the earlier use group, and 201.8 \u00b1 127.3 days in the later use group. During the median follow-up of 721 days, primary outcome occurred in 21 patients (18.3%). The earlier use group experienced significantly fewer primary outcome than the later use group (10.4% vs. 29.2%, P = 0.010). The Kaplan\u2013Meier survival curve showed better event-free survival in the earlier use group than in the later use group (log rank = 0.017). There were no significant differences in cardiac death, all-cause death, and ventricular arrhythmia between two groups (1.5% vs. 2.1%, P = 0.811; 1.5% vs. 4.2%, P = 0.375; 3.0% vs. 0%, P = 0.227, respectively). Despite a significantly lower baseline LVEF in the earlier use group (21.3 \u00b1 6.4% vs. 24.8 \u00b1 7.9%, P = 0.012), an early prominent increase of LVEF was noted before 6 months (35.2 \u00b1 11.9% vs. 27.8 \u00b1 8.8%, P = 0.007). A delayed improvement of LVEF in the later use group resulted in similar LVEF at last follow-up in both groups (40.7 \u00b1 13.4% vs. 39.4 \u00b1 10.9%, P = 0.686). Although the trajectory of left ventricular remodelling showed similar pattern in two groups, left atrial (LA) reverse remodelling was less prominent in the later use group during the follow-up period (final LA volume index: 43.6 \u00b1 14.3 mL\/m2 vs. 55.2 \u00b1 17.1 mL\/m2, P = 0.011).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Earlier use of Sac\/Val was related with better clinical outcome and earlier left ventricular reverse remodelling. Remodelling of LA was less prominent in the later use group implying delayed response in diastolic function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13940","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T02:55:32Z","timestamp":1651200932000},"page":"2435-2444","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Benefits of the Earlier Use of Sacubitril\/Valsartan in De Novo Heart Failure with Reduced Ejection Fraction Patients"],"prefix":"10.1093","volume":"9","author":[{"given":"Ji-Hye","family":"Oh","sequence":"first","affiliation":[{"name":"Department of Cardiology, School of Medicine, and Institute for Medical Science, Keimyung University , Daegu ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Man","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiology, School of Medicine, and Institute for Medical Science, Keimyung University , Daegu ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee-Jung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiology, School of Medicine, and Institute for Medical Science, Keimyung University , Daegu ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jongmin","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, School of Medicine, and Institute for Medical Science, Keimyung University , Daegu ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheol Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiology, School of Medicine, and Institute for Medical Science, Keimyung University , Daegu ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-Kyeong","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Cardiology, School of Medicine, and Institute for Medical Science, Keimyung University , Daegu ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyoung-Seob","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Cardiology, School of Medicine, and Institute for Medical Science, Keimyung University , Daegu ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyuck-Jun","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Cardiology, School of Medicine, and Institute for Medical Science, Keimyung University , Daegu ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Wook","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Cardiology, School of Medicine, and Institute for Medical Science, Keimyung University , Daegu ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyungseop","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Cardiology, School of Medicine, and Institute for Medical Science, Keimyung University , Daegu ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Wook","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Cardiology, School of Medicine, and Institute for Medical Science, Keimyung University , Daegu ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seongwook","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Cardiology, School of Medicine, and Institute for Medical Science, Keimyung University , Daegu 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