{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:20:09Z","timestamp":1769084409734,"version":"3.49.0"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":1317,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T00:00:00Z","timestamp":1651104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A 70-year-old woman who had cardiac sarcoidosis and severe tethering mitral regurgitation (MR) and had been implanted with a biventricular pacemaker experienced recurrent hospitalisation due to decompensated heart failure (HF). Application of MultiPoint\u2122 pacing reduced the MR volume and maintained the symptoms under control; however, the predicted longevity of the device significantly decreased because of the very high threshold of the added pacing site. Transcatheter mitral valve repair (TMVR) using MitraClip\u00ae was performed to further diminish the severe MR, thereby enabling the switch from highly consumptive multipoint pacing (MPP) to energy-saving single-point pacing. MPP could further reduce MR compared to the conventional single-point pacing, and this could be a bridging therapy to TMVR in some patients implanted with a biventricular pacemaker. This is the first case to report that switching from conventional single-point pacing to MPP decreased the MR, to some extent, resulting in the improvement of HF symptoms.<\/jats:p>","DOI":"10.1002\/ehf2.13944","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T05:43:20Z","timestamp":1651124600000},"page":"2724-2727","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Potential Efficacy of Multipoint Pacing in the Reduction of Mitral Regurgitation Volume: A Case Report"],"prefix":"10.1093","volume":"9","author":[{"given":"Masato","family":"Wada","sequence":"first","affiliation":[{"name":"Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University , Yufu ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2451-5845","authenticated-orcid":false,"given":"Hidekazu","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University , Yufu ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University , Yufu ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kunisaki City Hospital , Kunisaki ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirochika","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University , Yufu ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Yonezu","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University , Yufu ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Uemura","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University , Yufu ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University , Yufu ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shotaro","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University , Yufu ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Shuto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Faculty of Medicine, Oita University , Yufu ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Faculty of Medicine, Oita University , Yufu ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunio","family":"Yufu","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University , Yufu ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiki","family":"Nobe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kunisaki City Hospital , Kunisaki ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Faculty of Medicine, Oita University , Yufu ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohiko","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Clinical Examination, Faculty of Medicine, Oita University , Yufu ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,4,28]]},"reference":[{"key":"2026012114143381400_ehf213944-bib-0001","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1136\/hrt.2011.225789","article-title":"Independent prognostic value of functional mitral regurgitation in patients with heart failure. A quantitative analysis of 1256 patients with ischaemic and non-ischaemic dilated cardiomyopathy","volume":"97","author":"Rossi","year":"2011","journal-title":"Heart"},{"key":"2026012114143381400_ehf213944-bib-0002","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1093\/eurheartj\/ehab086","article-title":"The management of secondary mitral regurgitation in patients with heart failure: a joint position statement from the heart failure association (HFA), European Association of Cardiovascular Imaging (EACVI), European heart rhythm association (EHRA), and European Association of Percutaneous Cardiovascular Interventions (EAPCI) of the ESC","volume":"42","author":"Coats","year":"2021","journal-title":"Eur Heart J"},{"key":"2026012114143381400_ehf213944-bib-0003","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1161\/CIRCULATIONAHA.110.009803","article-title":"Cardiac resynchronization therapy as a therapeutic option in patients with moderate-severe functional mitral regurgitation and high operative risk","volume":"124","author":"van Bommel","year":"2011","journal-title":"Circulation"},{"key":"2026012114143381400_ehf213944-bib-0004","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.1002\/ehf2.13585","article-title":"Suppression of acute heart failure rehospitalization by biventricular pacing in wide QRS and mid-range ejection fraction","volume":"8","author":"Akamine","year":"2021","journal-title":"ESC Heart Fail"},{"key":"2026012114143381400_ehf213944-bib-0005","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.013352","article-title":"Transcatheter mitral valve replacement in the transcatheter aortic valve replacement era","volume":"8","author":"Testa","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"2026012114143381400_ehf213944-bib-0006","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s10840-014-9891-1","article-title":"Improvement in acute contractility and hemodynamics with multipoint pacing via a left ventricular quadripolar pacing lead","volume":"40","author":"Rinaldi","year":"2014","journal-title":"J Interv Card Electrophysiol"},{"key":"2026012114143381400_ehf213944-bib-0007","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1093\/europace\/euv211","article-title":"The use of multisite left ventricular pacing via quadripolar lead improves acute haemodynamics and mechanical dyssynchrony assessed by radial strain speckle tracking: Initial results","volume":"18","author":"Osca","year":"2016","journal-title":"Europace"},{"key":"2026012114143381400_ehf213944-bib-0008","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.hrthm.2015.02.008","article-title":"Improving cardiac resynchronization therapy response with multipoint left ventricular pacing: twelve-month follow-up study","volume":"12","author":"Pappone","year":"2015","journal-title":"Heart Rhythm"},{"key":"2026012114143381400_ehf213944-bib-0009","first-page":"1170","article-title":"Multipoint pacing via a quadripolar left-ventricular lead: preliminary results from the Italian registry on multipoint left-ventricular pacing in cardiac resynchronization therapy (IRON-MPP)","volume":"19","author":"Forleo","year":"2017","journal-title":"Europace"},{"key":"2026012114143381400_ehf213944-bib-0010","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.120.008680","article-title":"Left ventricular enlargement, cardiac resynchronization therapy efficacy, and impact of multipoint pacing","volume":"13","author":"Varma","year":"2020","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2026012114143381400_ehf213944-bib-0011","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.hrthm.2015.04.029","article-title":"Characterization of ventricular activation pattern and acute hemodynamics during multipoint left ventricular pacing","volume":"12","author":"Menardi","year":"2015","journal-title":"Heart Rhythm"},{"key":"2026012114143381400_ehf213944-bib-0012","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.jacep.2017.06.022","article-title":"Safety and efficacy of multipoint pacing in cardiac resynchronization therapy: the multipoint pacing trial","volume":"3","author":"Niazi","year":"2017","journal-title":"JACC Clin Electrophysiol"},{"key":"2026012114143381400_ehf213944-bib-0013","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1093\/eurheartj\/ehz109","article-title":"Cardiac resynchronization therapy non-responder to responder conversion rate in the more response to cardiac resynchronization therapy with multipoint pacing (MORE-CRT MPP) study: results from phase I","volume":"40","author":"Leclercq","year":"2019","journal-title":"Eur Heart J"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ehf2.13944","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ehf2.13944","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/9\/4\/2724\/65349207\/eschf_9_4_2724.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/9\/4\/2724\/65349207\/eschf_9_4_2724.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T19:17:13Z","timestamp":1769023033000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/9\/4\/2724\/8322938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,28]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,4,28]]},"published-print":{"date-parts":[[2022,8,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ehf2.13944","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,8]]},"published":{"date-parts":[[2022,4,28]]},"assertion":[{"value":"2022-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}