{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:20:05Z","timestamp":1769084405767,"version":"3.49.0"},"reference-count":9,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":1329,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T00:00:00Z","timestamp":1650067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology of Japan","doi-asserted-by":"crossref","award":["21K16050"],"award-info":[{"award-number":["21K16050"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pulmonary arterial hypertension (PAH) is a progressively life-threatening disease that causes right heart failure (RHF). Renal dysfunction frequently complicates PAH with RHF and is associated with a worse prognosis. Renal replacement therapy (RRT) may be a therapeutic option, although its efficacy and safety are unclear. We describe a 30-year-old male with severe PAH who developed renal insufficiency and diuretic-refractory volume overload complicated with RHF but was successfully managed with intermittent RRT via a subcutaneously fixed superficial artery for 4 years. RRT led to haemodynamic stability, which enabled us to carefully de-titrate parenteral PAH drugs without worsening RHF. This case highlights that RRT may be a potential alternative for haemodynamic and volume control of refractory fluid retention complicated with RHF in severe PAH cases. Further studies are warranted to gain more insight into patient selection and the optimal timing of RRT in PAH patients with deteriorating RHF.<\/jats:p>","DOI":"10.1002\/ehf2.13945","type":"journal-article","created":{"date-parts":[[2022,4,16]],"date-time":"2022-04-16T03:39:32Z","timestamp":1650080372000},"page":"2728-2731","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Renal Replacement Therapy as a Therapeutic Option for Right Heart Failure in Severe Pulmonary Arterial Hypertension"],"prefix":"10.1093","volume":"9","author":[{"given":"Mai","family":"Shimbo","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Tokyo Hospital , Tokyo ,","place":["Japan"]},{"name":"Department of Computational Diagnostic Radiology and Preventive Medicine, The University of Tokyo Hospital , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Hatano","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Tokyo Hospital , Tokyo ,","place":["Japan"]},{"name":"Department of Advanced Medical Center for Heart Failure, The University of Tokyo Hospital , 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Tokyo Hospital , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihito","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Tokyo Hospital , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Yagi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Tokyo Hospital , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Minatsuki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Tokyo Hospital , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisataka","family":"Maki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Tokyo Hospital , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eisuke","family":"Amiya","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Tokyo Hospital , Tokyo ,","place":["Japan"]},{"name":"Department of Therapeutic Strategy for Heart Failure, The University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norifumi","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Tokyo Hospital , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Issei","family":"Komuro","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Tokyo Hospital , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,4,16]]},"reference":[{"key":"2026012114143271500_ehf213945-bib-0001","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.jacc.2008.01.024","article-title":"Pulmonary arterial hypertension","volume":"51","author":"Chin","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"2026012114143271500_ehf213945-bib-0002","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.cardfail.2011.03.003","article-title":"Incidence, correlates, and consequences of acute kidney injury in patients with pulmonary arterial hypertension hospitalized with acute right-side heart failure","volume":"17","author":"Haddad","year":"2011","journal-title":"J Card Fail"},{"key":"2026012114143271500_ehf213945-bib-0003","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.jacc.2020.06.070","article-title":"Contemporary management of severe acute kidney injury and refractory cardiorenal syndrome","volume":"76","author":"Jentzer","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"2026012114143271500_ehf213945-bib-0004","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1161\/CIRCULATIONAHA.107.719500","article-title":"Association of serum creatinine with abnormal hemodynamics and mortality in pulmonary arterial hypertension","volume":"117","author":"Shah","year":"2008","journal-title":"Circulation"},{"key":"2026012114143271500_ehf213945-bib-0005","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1159\/000339346","article-title":"Renal replacement therapy in patients with severe precapillary pulmonary hypertension with acute right heart failure","volume":"85","author":"Sztrymf","year":"2013","journal-title":"Respiration"},{"key":"2026012114143271500_ehf213945-bib-0006","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s41030-018-0052-z","article-title":"Volume management in pulmonary arterial hypertension patients: an expert pulmonary hypertension clinician perspective","volume":"4","author":"Hansen","year":"2018","journal-title":"Pulm Ther"},{"key":"2026012114143271500_ehf213945-bib-0007","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1183\/09031936.00070209","article-title":"Prognostic factors of acute heart failure in patients with pulmonary arterial hypertension","volume":"35","author":"Sztrymf","year":"2010","journal-title":"Eur Respir J"},{"key":"2026012114143271500_ehf213945-bib-0008","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1513\/AnnalsATS.201305-115LE","article-title":"Massive ascites in pulmonary arterial hypertension: caution with epoprostenol","volume":"10","author":"Kataoka","year":"2013","journal-title":"Ann Am Thorac Soc"},{"key":"2026012114143271500_ehf213945-bib-0009","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.jacc.2016.05.043","article-title":"High-output heart failure: a 15-year experience","volume":"68","author":"Reddy","year":"2016","journal-title":"J Am Coll Cardiol"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ehf2.13945","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ehf2.13945","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/9\/4\/2728\/65349204\/eschf_9_4_2728.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/9\/4\/2728\/65349204\/eschf_9_4_2728.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T19:17:14Z","timestamp":1769023034000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/9\/4\/2728\/8322937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,16]]},"references-count":9,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,4,16]]},"published-print":{"date-parts":[[2022,8,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ehf2.13945","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,8]]},"published":{"date-parts":[[2022,4,16]]},"assertion":[{"value":"2022-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}