{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:07:05Z","timestamp":1787162825020,"version":"build-2736575974"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":1296,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T00:00:00Z","timestamp":1652918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Trias Talents 2021 Grant from Germans Trias i Pujol Hospital and fons de recerca \"HER\u00c8NCIA JMC\u201d"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Prior studies have not fully characterized the haemodynamic effects of the angiotensin receptor-neprilysin inhibitor (ARNI) sacubitril\/valsartan in heart failure with preserved ejection fraction and pulmonary hypertension (HFpEF\u2013PH). The aim of the Treatment of PH With Angiotensin II Receptor Blocker and Neprilysin Inhibitor in HFpEF Patients With CardioMEMS Device (ARNIMEMS-HFpEF) study is to assess pulmonary artery pressure (PAP) dynamics by means of implanted PAP monitors in patients with HFpEF\u2013PH treated with sacubitril\/valsartan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>This single-arm, investigator-initiated, interventional study included 14 consecutive ambulatory symptomatic HFpEF\u2013PH patients who underwent CardioMEMS implantation prior to enrolment [mean ejection fraction 60.4 \u00b1 7.2%, baseline mean PAP (mPAP) 33.9 \u00b1 7.6 mmHg]. Daily PAP values were examined during three periods: a 6 week period after CardioMEMS implantation and before sacubitril\/valsartan treatment (pre-ARNI), a 6 week period with sacubitril\/valsartan treatment (ARNI ON), and a 6 week period of sacubitril\/valsartan withdrawal (ARNI OFF). The primary endpoint was change in mPAP with and without sacubitril\/valsartan. Secondary endpoints included changes in 6 min walking distance, B-line sum in lung ultrasound, and quality of life (QoL). During the study period, 1717 mPAP measurements were recorded. Between pre-ARNI vs. ARNI ON, mPAP significantly declined by \u22124.99 mmHg [95% confidence interval (CI) \u22125.55 to \u22124.43]. Between ARNI ON vs. ARNI OFF, mPAP significantly increased by +2.84 mmHg [95% CI +2.26 to +3.42]. Between pre-ARNI vs. ARNI ON, we found an improvement in 6 min walking distance, B-lines, and QoL. Mean loop diuretic management did not differ between periods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sacubitril\/valsartan significantly reduced mPAP in patients with HFpEF\u2013PH, independent of loop diuretic management, together with improvement in functional capacity, lung congestion, and QoL. Sacubitril\/valsartan may be a therapeutic alternative in HFpEF\u2013PH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13952","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T05:49:23Z","timestamp":1652939363000},"page":"2170-2180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Sacubitril\/Valsartan Affects Pulmonary Arterial Pressure in Heart Failure with Preserved Ejection Fraction and Pulmonary Hypertension"],"prefix":"10.1093","volume":"9","author":[{"given":"Pau","family":"Codina","sequence":"first","affiliation":[{"name":"Heart Institute, University Hospital Germans Trias i Pujol , Badalona ,","place":["Spain"]},{"name":"Department of Medicine, Universitat Autonoma de Barcelona , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar","family":"Domingo","sequence":"additional","affiliation":[{"name":"Heart Institute, University Hospital Germans Trias i Pujol , Badalona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Barcel\u00f3","sequence":"additional","affiliation":[{"name":"Heart Institute, University Hospital Germans Trias i Pujol , Badalona ,","place":["Spain"]},{"name":"ICREC Research Program, Fundaci\u00f3 Institut d'Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol (IGTP) , Barcelona ,","place":["Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Gastelurrutia","sequence":"additional","affiliation":[{"name":"ICREC Research Program, Fundaci\u00f3 Institut d'Investigaci\u00f3 en Ci\u00e8ncies de la Salut Germans Trias i Pujol (IGTP) , Barcelona ,","place":["Spain"]},{"name":"Institut d'Investigaci\u00f3 Biom\u00e8dica de Bellvitge-IDIBELL , L'Hospitalet de Llobregat 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