{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:28:06Z","timestamp":1790616486739,"version":"4.1.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":1302,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T00:00:00Z","timestamp":1652400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Heart failure may lead to brain functional alterations related to cognitive impairment. This study aimed to detect alterations of static functional network connectivity (FNC) and dynamic FNC in heart failure with preserved ejection fraction (HFpEF) and to estimate the association between the altered FNC and clinical features related to HFpEF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>The clinical and resting-state functional magnetic resonance imaging (fMRI) data of HFpEF patients (n = 35) and healthy controls (HCs) (n = 35) were acquired at baseline. Resting-state networks (RSNs) were established based on independent component analysis (ICA) and FNC analyses were performed. The associations between the FNC abnormalities and clinical features related to HFpEF were analysed. Compared with HCs, HFpEF patients showed decreased functional connectivity within the default mode network, left frontoparietal network, and right frontoparietal network and increased functional connectivity within the right frontoparietal network and visual network. Negative correlations were observed between decreased dynamic FNC and the left ventricular end-diastolic diameter (LVDd) (r = \u22120.435, P = 0.015) as well as the left ventricular end-systolic diameter (LVDs) (r = \u22120.443, P = 0.013).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The FNC disruption and altered temporal properties of functional dynamics in HFpEF patients may reflect the neural mechanisms of brain injury after HFpEF, which may deepen our understanding of the disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13967","type":"journal-article","created":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T05:40:52Z","timestamp":1652420452000},"page":"2558-2566","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Aberrant Static and Dynamic Functional Network Connectivity in Heart Failure with Preserved Ejection Fraction"],"prefix":"10.1093","volume":"9","author":[{"given":"Liang","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Radiology, Nanjing First Hospital, Nanjing Medical University , Nanjing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nanjing First Hospital, Nanjing Medical University , Nanjing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Echocardiography, Nanjing First Hospital, Nanjing Medical University , Nanjing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nanjing First Hospital, Nanjing Medical University , Nanjing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongping","family":"Ai","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nanjing First Hospital, Nanjing Medical University , Nanjing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyou","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nanjing First Hospital, Nanjing Medical University , Nanjing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xindao","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nanjing First Hospital, Nanjing Medical University , Nanjing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Nanjing First Hospital, Nanjing Medical University , Nanjing ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,5,13]]},"reference":[{"key":"2026012114151478700_ehf213967-bib-0001","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nrcardio.2017.65","article-title":"Epidemiology of heart failure with preserved ejection fraction","volume":"14","author":"Dunlay","year":"2017","journal-title":"Nat Rev Cardiol"},{"key":"2026012114151478700_ehf213967-bib-0002","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1177\/0898264313505111","article-title":"Longitudinal differences in cognitive functioning among older adults with and without heart failure","volume":"25","author":"Alwerdt","year":"2013","journal-title":"J Aging Health"},{"key":"2026012114151478700_ehf213967-bib-0003","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s10741-015-9488-5","article-title":"Structural brain alterations in heart failure: a review of the literature and implications for risk of Alzheimer's disease","volume":"20","author":"Alosco","year":"2015","journal-title":"Heart Fail Rev"},{"key":"2026012114151478700_ehf213967-bib-0004","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1016\/j.jacc.2020.03.053","article-title":"Associations between cardiovascular risk, structural brain changes, and cognitive decline","volume":"75","author":"Song","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"2026012114151478700_ehf213967-bib-0005","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.jchf.2018.03.010","article-title":"Cognitive deficits and related brain lesions in patients with chronic heart failure","volume":"6","author":"Frey","year":"2018","journal-title":"JACC Heart Fail"},{"key":"2026012114151478700_ehf213967-bib-0006","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1093\/eurheartj\/ehab003","article-title":"Temporal changes in total and hippocampal brain volume and cognitive function in patients with chronic heart failure\u2014the COGNITION.MATTERS-HF cohort study","volume":"42","author":"Frey","year":"2021","journal-title":"Eur Heart J"},{"key":"2026012114151478700_ehf213967-bib-0007","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cardfail.2012.12.001","article-title":"Visual assessment of brain magnetic resonance imaging detects injury to cognitive regulatory sites in patients with heart failure","volume":"19","author":"Pan","year":"2013","journal-title":"J Card Fail"},{"key":"2026012114151478700_ehf213967-bib-0008","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1093\/eurjhf\/hft029","article-title":"Brain and mood changes over 2 years in healthy controls and adults with heart failure and ischaemic heart disease","volume":"15","author":"Almeida","year":"2013","journal-title":"Eur J Heart Fail"},{"key":"2026012114151478700_ehf213967-bib-0009","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1093\/eurheartj\/ehr467","article-title":"Cognitive and brain changes associated with ischaemic heart disease and heart failure","volume":"33","author":"Almeida","year":"2012","journal-title":"Eur Heart J"},{"key":"2026012114151478700_ehf213967-bib-0010","article-title":"Lateralized resting-state functional brain network organization changes in heart failure","volume":"11","author":"Park","year":"2016","journal-title":"PLoS ONE"},{"key":"2026012114151478700_ehf213967-bib-0011","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.neuroimage.2005.08.035","article-title":"fMRI resting state networks define distinct modes of long-distance interactions in the human brain","volume":"29","author":"De Luca","year":"2006","journal-title":"Neuroimage"},{"key":"2026012114151478700_ehf213967-bib-0012","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nrn2201","article-title":"Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging","volume":"8","author":"Fox","year":"2007","journal-title":"Nat Rev Neurosci"},{"key":"2026012114151478700_ehf213967-bib-0013","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7058953","article-title":"Functional connectivity alterations in children with spastic and dyskinetic cerebral palsy","volume":"2018","author":"Qin","year":"2018","journal-title":"Neural Plast"},{"key":"2026012114151478700_ehf213967-bib-0014","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/ejhf.592","article-title":"2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC","volume":"18","author":"Ponikowski","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"2026012114151478700_ehf213967-bib-0015","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.acvd.2013.11.002","article-title":"Baseline characteristics of patients with heart failure and preserved ejection fraction included in the Karolinska Rennes (KaRen) study","volume":"107","author":"Donal","year":"2014","journal-title":"Arch Cardiovasc Dis"},{"key":"2026012114151478700_ehf213967-bib-0016","first-page":"458","article-title":"The Modified Mini-Mental State Examination test: normative data for Singapore Chinese older adults and its performance in detecting early cognitive impairment","volume":"53","author":"Feng","year":"2012","journal-title":"Singapore Med J"},{"key":"2026012114151478700_ehf213967-bib-0017","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jns.2010.08.051","article-title":"The Montreal Cognitive Assessment (MoCA) is superior to the Mini-Mental State Examination (MMSE) for the detection of vascular cognitive impairment after acute stroke","volume":"299","author":"Dong","year":"2010","journal-title":"J Neurol Sci"},{"key":"2026012114151478700_ehf213967-bib-0018","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.neuroimage.2005.02.018","article-title":"Unified segmentation","volume":"26","author":"Ashburner","year":"2005","journal-title":"Neuroimage"},{"key":"2026012114151478700_ehf213967-bib-0019","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1002\/hbm.20359","article-title":"Estimating the number of independent components for functional magnetic resonance imaging data","volume":"28","author":"Li","year":"2007","journal-title":"Hum Brain Mapp"},{"key":"2026012114151478700_ehf213967-bib-0020","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1002\/hbm.1048","article-title":"A method for making group inferences from functional MRI data using independent component analysis","volume":"14","author":"Calhoun","year":"2001","journal-title":"Hum Brain Mapp"},{"key":"2026012114151478700_ehf213967-bib-0021","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8894868","article-title":"Large-scale internetwork functional connectivity mediates the relationship between serum triglyceride and working memory in young adulthood","volume":"2020","author":"Wang","year":"2020","journal-title":"Neural Plast"},{"key":"2026012114151478700_ehf213967-bib-0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejrad.2020.109324","article-title":"Aberrant dynamic functional network connectivity in cirrhotic patients without overt hepatic encephalopathy","volume":"132","author":"Jiang","year":"2020","journal-title":"Eur J Radiol"},{"key":"2026012114151478700_ehf213967-bib-0023","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.nicl.2014.07.003","article-title":"Dynamic functional connectivity analysis reveals transient states of dysconnectivity in schizophrenia","volume":"5","author":"Damaraju","year":"2014","journal-title":"Neuroimage Clin"},{"key":"2026012114151478700_ehf213967-bib-0024","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.schres.2015.11.021","article-title":"Interaction among subsystems within default mode network diminished in schizophrenia patients: a dynamic connectivity approach","volume":"170","author":"Du","year":"2016","journal-title":"Schizophr Res"},{"key":"2026012114151478700_ehf213967-bib-0025","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1192\/bjp.2019.10","article-title":"Resting-state neural network disturbances that underpin the emergence of emotional symptoms in adolescent girls: resting-state fMRI study","volume":"215","author":"Malhi","year":"2019","journal-title":"Br J Psychiatry"},{"key":"2026012114151478700_ehf213967-bib-0026","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1111\/j.1532-5415.2007.01395.x","article-title":"Profile of cognitive impairment in chronic heart failure","volume":"55","author":"Vogels","year":"2007","journal-title":"J Am Geriatr Soc"},{"key":"2026012114151478700_ehf213967-bib-0027","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.amjcard.2010.10.017","article-title":"Patient perception versus medical record entry of health-related conditions among patients with heart failure","volume":"107","author":"Malik","year":"2011","journal-title":"Am J Cardiol"},{"key":"2026012114151478700_ehf213967-bib-0028","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1177\/1073858412446202","article-title":"Emerging roles of the brain's default network","volume":"19","author":"Mantini","year":"2013","journal-title":"Neuroscientist"},{"key":"2026012114151478700_ehf213967-bib-0029","doi-asserted-by":"crossref","first-page":"133","DOI":"10.31887\/DCNS.2018.20.2\/smarek","article-title":"The frontoparietal network: function, electrophysiology, and importance of individual precision mapping","volume":"20","author":"Marek","year":"2018","journal-title":"Dialogues Clin Neurosci"},{"key":"2026012114151478700_ehf213967-bib-0030","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.cardfail.2008.10.020","article-title":"Brain injury in autonomic, emotional, and cognitive regulatory areas in patients with heart failure","volume":"15","author":"Woo","year":"2009","journal-title":"J Card Fail"},{"key":"2026012114151478700_ehf213967-bib-0031","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.1002\/hbm.24183","article-title":"Altered intra- and inter-network functional coupling of resting-state networks associated with motor dysfunction in stroke","volume":"39","author":"Zhao","year":"2018","journal-title":"Hum Brain Mapp"},{"key":"2026012114151478700_ehf213967-bib-0032","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3389\/fnins.2016.00199","article-title":"Effects of aging and adult-onset hearing loss on cortical auditory regions","volume":"10","author":"Cardin","year":"2016","journal-title":"Front Neurosci"},{"key":"2026012114151478700_ehf213967-bib-0033","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/chf.12001","article-title":"Cognitive profile in persons with systolic and diastolic heart failure","volume":"19","author":"Athilingam","year":"2013","journal-title":"Congest Heart Fail"},{"key":"2026012114151478700_ehf213967-bib-0034","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.jacc.2017.01.022","article-title":"Heart failure-induced brain injury","volume":"69","author":"Havakuk","year":"2017","journal-title":"J Am Coll Cardiol"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ehf2.13967","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ehf2.13967","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/9\/4\/2558\/65349371\/eschf_9_4_2558.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/9\/4\/2558\/65349371\/eschf_9_4_2558.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T19:18:02Z","timestamp":1769023082000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/9\/4\/2558\/8322992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,13]]},"references-count":34,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,5,13]]},"published-print":{"date-parts":[[2022,8,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ehf2.13967","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,8]]},"published":{"date-parts":[[2022,5,13]]},"assertion":[{"value":"2021-07-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}