{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T03:49:30Z","timestamp":1781840970759,"version":"3.54.5"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":1286,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T00:00:00Z","timestamp":1653782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC1301001"],"award-info":[{"award-number":["2016YFC1301001"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC1301001"],"award-info":[{"award-number":["2016YFC1301001"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate the impact of intra-aortic balloon pump (IABP) on the regional haemodynamics of patients with severe cardiogenic shock undergoing femoro-femoral veno-arterial extracorporeal membrane oxygenation (VA-ECMO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>From July 2017 to April 2018, a total of 39 adult patients with cardiogenic shock receiving both IABP and ECMO for circulatory support were enrolled consecutively in a university-affiliated cardiac surgery intensive care unit. The blood flow rates (BFRs) of the bilateral femoral artery (IABP side: iFA, ECMO side: eFA) and carotid artery (left: LCA, right: RCA) and the velocity time integral (VTI) of aortic root were assessed by ultrasonography and compared when IABP was on and off. Seventeen of 39 (43.6%) patients survived to discharge, and 29 (74.4%) survived on ECMO. A total of 172 pairs of data (IABP on and off) were collected in this study, measured on the median of 2.0 (1.0, 4.5) days after patients received VA-ECMO. The BFR on both sides of FA (iFA: 176.4 \u00b1 104.5 vs. 152.2 \u00b1 139.8 mL\/min, P &amp;lt; 0.01; eFA: 299.3 \u00b1 279.9 vs. 242.4 \u00b1 258.8 mL\/min, P &amp;lt; 0.01) and the aortic VTI (10.1 \u00b1 4.4 vs. 8.5 \u00b1 4.4 cm, P &amp;lt; 0.01) decreased significantly when turning the IABP off, while the BFR on both sides of CA remained unchanged (LCA: 555.7 \u00b1 326.9 vs. 578.6 \u00b1 328.0 mL\/min, P = 0.27; RCA: 550.0 \u00b1 331.1 vs. 533.0 \u00b1 303.5 mL\/min, P = 0.30). The LCA BFR dramatically increased after turning the IABP off (296.8 \u00b1 129.7 vs. 401.4 \u00b1 278.1 mL\/min, P = 0.02) in patients with cardiac stunning (defined as pulse pressure \u2264 5 mmHg). However, there was no significant difference in LCA BFR between IABP-On and IABD-Off (359.6 \u00b1 105.4 mL\/min vs. 389.6 \u00b1 139.3 mL\/min, P = 0.31) in patients with cardiac stunning receiving a higher ECMO blood flow (&amp;gt; 3.5 L\/min).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Concomitant IABP used in patients undergoing femoro-femoral VA-ECMO was associated with increased aortic VTI and BFR in bilateral FA. The change in CA BFR depended on cardiac function. A decreased LCA BFR was observed in patients with cardiac stunning when IABP was turned on, which might be compensated by a higher ECMO blood flow. Further study is needed to confirm the relationship between BFR and extremities and neurological complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.13981","type":"journal-article","created":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T21:14:25Z","timestamp":1653858865000},"page":"2610-2617","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Intra-Aortic Balloon Pump Impacts the Regional Haemodynamics of Patients with Cardiogenic Shock Treated with Femoro-Femoral Veno-Arterial Extracorporeal Membrane Oxygenation"],"prefix":"10.1093","volume":"9","author":[{"given":"Bo","family":"Xu","sequence":"first","affiliation":[{"name":"Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University , Beijing ,","place":["P.R. 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China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongtao","family":"Du","sequence":"additional","affiliation":[{"name":"Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University , Beijing ,","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiushi","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Public Health, Capital Medical University , Beijing ,","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Guo","sequence":"additional","affiliation":[{"name":"Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University , Beijing ,","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjing","family":"Jiang","sequence":"additional","affiliation":[{"name":"Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University , Beijing ,","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichen","family":"Xing","sequence":"additional","affiliation":[{"name":"Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University , Beijing ,","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Xin","sequence":"additional","affiliation":[{"name":"Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University , Beijing ,","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengcheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University , Beijing ,","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangshan","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University , Beijing ,","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Yang","sequence":"additional","affiliation":[{"name":"Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University , Beijing ,","place":["P.R. China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Jia","sequence":"additional","affiliation":[{"name":"Center for Cardiac Intensive Care, Beijing Anzhen Hospital, Capital Medical University , Beijing ,","place":["P.R. 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