{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:13:18Z","timestamp":1777443198080,"version":"3.51.4"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":1263,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["201439013C"],"award-info":[{"award-number":["201439013C"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sakakibara Clinical Research Grant for the Promotion of Science","award":["2012 to 2020"],"award-info":[{"award-number":["2012 to 2020"]}]},{"name":"Health Labour Science Research Grant","award":["14528506"],"award-info":[{"award-number":["14528506"]}]},{"name":"Grant-in-Aid from the Japanese Ministry of Health, Labor and Welfare","award":["H29-Refractory Disease-034"],"award-info":[{"award-number":["H29-Refractory Disease-034"]}]},{"name":"Grant-in-Aid for Clinical Research from the Japanese Circulation Society","award":["2019"],"award-info":[{"award-number":["2019"]}]},{"name":"Grant-in-Aid for Young Scientists","award":["18K15860"],"award-info":[{"award-number":["18K15860"]}]},{"name":"Grant-in-Aid for Scientific Research","award":["23591062"],"award-info":[{"award-number":["23591062"]}]},{"name":"Grant-in-Aid for Scientific Research","award":["26461088"],"award-info":[{"award-number":["26461088"]}]},{"name":"Grant-in-Aid for Scientific Research","award":["17K09526"],"award-info":[{"award-number":["17K09526"]}]},{"name":"Grant-in-Aid for Scientific Research","award":["18K08056"],"award-info":[{"award-number":["18K08056"]}]},{"name":"Grant-in-Aid for Scientific Research","award":["21K08142"],"award-info":[{"award-number":["21K08142"]}]},{"DOI":"10.13039\/501100006595","name":"Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii","doi-asserted-by":"publisher","award":["201439013C"],"award-info":[{"award-number":["201439013C"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Furosemide, a short-acting loop diuretic (SD), is the dominant agent prescribed for heart failure (HF) in clinical practice. However, accumulating data suggests that long-acting loop diuretics (LD), such as torsemide or azosemide, might have more favourable pharmacological profiles. This study aimed to investigate the relationship between the type of loop diuretics and long-term outcomes among patients hospitalized for acute HF enrolled in a contemporary multicentre registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Within the West Tokyo Heart Failure Registry from 2006 to 2017, a total of 2680 patients (60.1% men with a median age of 77 years) were analysed. The patients were characterized by the type of diuretics used at the time of discharge; 2073 (77.4%) used SD, and 607 (22.6%) used LD. The primary endpoint was composite of all-cause death or HF re-admission after discharge, and the secondary endpoints were all-cause death and HF re-admission, respectively. During the median follow-up period of 2.1 years, 639 patients died [n = 519 (25.0%) in the SD group; n = 120 (19.8%) in the LD group], and 868 patients were readmitted for HF [n = 697 (33.6%) in the SD group; n = 171 (28.2%) in the LD group]. After multivariable adjustment, the LD group had lower risk for the composite outcome [hazard ratio (HR), 0.80; 95% confidence interval (CI), 0.66\u20130.96; P = 0.017], including all-cause death (HR; 0.73; 95% CI; 0.54\u20130.99; P = 0.044) and HF re-admission (HR, 0.81; 95% CI, 0.66\u20130.99; P = 0.038), than the SD group. Propensity score matching yielded estimates that were consistent with those of the multivariable analyses, with sub-group analyses demonstrating that use of LD was associated with favourable outcomes predominantly in younger patients with reduced ejection fraction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LD was associated with lower risk of long-term outcomes in patients with HF and a recent episode of acute decompensation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.14030","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T02:45:36Z","timestamp":1655865936000},"page":"2967-2977","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Use of Short-Acting vs. Long-Acting Loop Diuretics After Heart Failure Hospitalization"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6211-1617","authenticated-orcid":false,"given":"Shohei","family":"Imaeda","sequence":"first","affiliation":[{"name":"Department of Cardiology, Keio University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Shiraishi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Keio University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Kohsaka","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Keio University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomi","family":"Niimi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Keio University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumi","family":"Goda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Kyorin University Fuculty of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Nagatomo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Defense Medical College Hospital , Tokorozawa ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Takei","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Saiseikai Central Hospital , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike","family":"Saji","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sakakibara Heart Institute , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Saitama Medical University International Medical Center , Saitama ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kohno","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Kyorin University Fuculty of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Keio University School of Medicine , Tokyo ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sakakibara Heart Institute , Tokyo 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