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Although the harmful effects of opioid abuse and overdose are well understood, little is known about the long-term cardiovascular (CV) effects of prescribed opioids. The aim of this study was to investigate the CV effects associated with prescribed opioid use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>A post hoc analysis of participants in the Aspirin in Reducing Events in the Elderly (ASPREE) trial was conducted. Participants in the ASPREE trial included community-dwelling older adults without a prior history of CV disease (CVD). Prescribed opioid use was defined as opioid use at baseline and\/or at the first annual visit (AV1). Cox proportional hazards regression was used to calculate hazard ratios and 95% confidence intervals (95% CI) for associations between opioid use and CVD events following AV1. Of the 17\u2009701 participants included (mean age 75.2 years, 58.2% female), 813 took opioids either at baseline or at AV1. Over a median follow-up period of 3.58 years (IQR 2.50\u20134.62), CVD events, most notably heart failure hospitalization, occurred in 7% (n = 57) amongst opioid users and 4% (n = 680) amongst non-opioid users. After adjustment for multiple covariates, opiate use was associated with a 1.67-fold (CI 1.26\u20132.23, P &amp;lt; 0.001) increase in the hazard ratio for CVD events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings identify opioid use as a non-traditional risk factor for CVD events in community-dwelling older adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.14101","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T20:40:27Z","timestamp":1660941627000},"page":"3973-3984","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Prescribed Opioid Use is Associated with Adverse Cardiovascular Outcomes in Community-Dwelling Older Persons"],"prefix":"10.1093","volume":"9","author":[{"given":"Stephanie M.","family":"Liew","sequence":"first","affiliation":[{"name":"Cardiology Department, Alfred Hospital , Melbourne, VIC ,","place":["Australia"]},{"name":"Department of Cardiology, University Hospital Geelong , Geelong, VIC ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enayet K.","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine, Monash University , Melbourne, VIC ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Ernst","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice and Science, College of Pharmacy and Department of Family Medicine, Carver College of Medicine, The University of Iowa , Iowa City, IA ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Gilmartin-Thomas","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine, Monash University , Melbourne, VIC ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Reid","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine, Monash University , Melbourne, VIC ,","place":["Australia"]},{"name":"School of Population Health, Curtin University , Perth, WA ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Tonkin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine, Monash University , Melbourne, VIC ,","place":["Australia"]},{"name":"Department of Cardiology, Austin Health , Melbourne, VIC ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Neumann","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine, Monash University , Melbourne, VIC ,","place":["Australia"]},{"name":"Department of Cardiology, University Medical Centre Hamburg , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"McNeil","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine, Monash University , Melbourne, VIC ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Kaye","sequence":"additional","affiliation":[{"name":"Cardiology Department, Alfred Hospital , Melbourne, VIC ,","place":["Australia"]},{"name":"Department of Cardiology, University Medical Centre Hamburg , Hamburg ,","place":["Germany"]},{"name":"Baker Heart and Diabetes Institute , Melbourne 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