{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:48:12Z","timestamp":1791510492340,"version":"4.3.4"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":1214,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005937","name":"Cheng Hsin General Hospital","doi-asserted-by":"publisher","award":["CHGH111-(N)10"],"award-info":[{"award-number":["CHGH111-(N)10"]}],"id":[{"id":"10.13039\/501100005937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010101","name":"Taichung Veteran General Hospital","doi-asserted-by":"publisher","award":["TCVGH-1093103C"],"award-info":[{"award-number":["TCVGH-1093103C"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010101","name":"Taichung Veteran General Hospital","doi-asserted-by":"publisher","award":["TCVGH-1103103C"],"award-info":[{"award-number":["TCVGH-1103103C"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005937","name":"Cheng Hsin General Hospital Foundation","doi-asserted-by":"publisher","award":["CHGH111\u2010(N)10"],"award-info":[{"award-number":["CHGH111\u2010(N)10"]}],"id":[{"id":"10.13039\/501100005937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"publisher","award":["TCVGH\u20101093103C"],"award-info":[{"award-number":["TCVGH\u20101093103C"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"publisher","award":["TCVGH\u20101103103C"],"award-info":[{"award-number":["TCVGH\u20101103103C"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Sacubitril\/valsartan (SAC\/VAL) has been used in patients with heart failure and reduced ejection fraction (HFrEF), and cardiac resynchronization therapy (CRT) could benefit the HFrEF patients with wide QRS durations. This study aimed to evaluate the clinical impacts of SAC\/VAL on reverse cardiac remodelling in CRT-eligible and CRT-ineligible HFrEF patients with different QRS durations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>The TAROT-HF study was a multicentre, observational study enrolling patients who initiated SAC\/VAL from 10 hospitals since 2017. Patients with baseline left ventricular ejection fraction (LVEF) \u2264 35% were classified into two groups: (i) Group 1: CRT-eligible group, patients with left bundle branch block (LBBB) morphology plus QRS duration \u2265130 ms or non-LBBB morphology plus QRS duration \u2265150 ms; and (ii) Group 2: CRT-ineligible group. Propensity score matching was performed to adjust for confounders, and 1168 patients were analysed. Baseline characteristics were comparable between the two groups. The improvements in LVEF and left ventricular end-systolic volume index (LVESVi) were more significant in Group 2 than in Group 1 after 1 year SAC\/VAL treatment (LVEF: 8.4% \u00b1 11.3% vs. 4.5% \u00b1 8.1%, P &amp;lt; 0.001; change percentages in LVESVi: \u221214.4% \u00b1 25.9% vs. \u22129.6% \u00b1 23.1%, P = 0.004). LVEF improving to \u226550% in Groups 1 and 2 constituted 5.2% and 20.2% after 1 year SAC\/VAL treatment (P &amp;lt; 0.001). Multivariate analyses showed that wide QRS durations were negatively associated with the reverse cardiac remodelling in these HFrEF patients with SAC\/VAL treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite SAC\/VAL treatment, wide QRS durations are associated with lower degrees of left ventricular improvement than narrow ones in the HFrEF patients. Optimal intervention timing for the CRT-eligible patients requires further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.14107","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T01:09:15Z","timestamp":1660093755000},"page":"3825-3835","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Clinical Impacts of Sacubitril\/Valsartan on Patients Eligible for Cardiac Resynchronization Therapy"],"prefix":"10.1093","volume":"9","author":[{"given":"Hsin-Ti","family":"Huang","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine and Medical Education, Taichung Veterans General Hospital , Taichung ,","place":["Taiwan"]},{"name":"Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Long","family":"Huang","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University , Taipei ,","place":["Taiwan"]},{"name":"Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University , Taichung ,","place":["Taiwan"]},{"name":"Department of Medical Education, Taichung Veterans General Hospital , Taichung ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Lin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medicine, MacKay Medical College , New Taipei ,","place":["Taiwan"]},{"name":"Division of Cardiology, Department of Internal Medicine, Hsinchu MacKay Memorial Hospital , Hsinchu ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Hsiang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, MacKay Medical College , New Taipei ,","place":["Taiwan"]},{"name":"Cardiovascular Center, MacKay Memorial Hospital , Taipei ,","place":["Taiwan"]},{"name":"Department of Artificial Intelligence and Medical Application, MacKay Junior College of Medicine, Nursing, and Management , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Yi","family":"Hsu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University , Taipei ,","place":["Taiwan"]},{"name":"Division of Cardiology and Cardiovascular Research Center, Department of Internal Medicine, Taipei Medical University Hospital , Taipei ,","place":["Taiwan"]},{"name":"Taipei Heart Institute, Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fa-Po","family":"Chung","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University , Taipei ,","place":["Taiwan"]},{"name":"Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Te","family":"Liao","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Chi-Mei Medical Center , Tainan ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Ru","family":"Chiou","sequence":"additional","affiliation":[{"name":"Department of Medicine, MacKay Medical College , New Taipei ,","place":["Taiwan"]},{"name":"Division of Cardiology, Taitung MacKay Memorial Hospital , Taitung ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Yu","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huai-Wen","family":"Liang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, E-Da Hospital; I-Shou University , Kaohsiung ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Yu","family":"Chang","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University , Taipei ,","place":["Taiwan"]},{"name":"Heart Center, Cheng Hsin General Hospital , Taipei ,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,8,9]]},"reference":[{"key":"2026012114135270500_ehf214107-bib-0001","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/ehf2.12005","article-title":"Heart failure: Preventing disease and death worldwide","volume":"1","author":"Ponikowski","year":"2014","journal-title":"ESC Heart Fail"},{"key":"2026012114135270500_ehf214107-bib-0002","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1161\/CIRCULATIONAHA.106.666016","article-title":"REVERT study group. 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