{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:45:21Z","timestamp":1769085921623,"version":"3.49.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":1205,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:00:00Z","timestamp":1660780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Heart failure with preserved ejection fraction (HFpEF) is one of the most rapidly growing cardiovascular health burden worldwide, but there is still a lack of understanding about the HFpEF pathophysiology. The nitric oxide (NO) signalling pathway has been identified as a potential key element. The aim of our study was to investigate markers of NO metabolism [l-arginine (l-Arg), homoarginine (hArg), and asymmetric and symmetric dimethylarginine (ADMA and SDMA)], additional biomarkers [N-terminal pro-B-type natriuretic peptide (NT-proBNP), endothelin-1 (ET-1), mid-regional pro-adrenomedullin (MR-proADM), copeptin, and high-sensitivity C-reactive protein (hsCRP)], and the endothelial function in an integrated approach focusing on associations with clinical characteristics in patients with HFpEF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Seventy-three patients, prospectively enrolled in the \u2018German HFpEF Registry\u2019, were analysed. Inclusion criteria were left ventricular ejection fraction (LVEF) \u2265 50%; New York Heart Association functional class \u2265 II; elevated levels of NT-proBNP &amp;gt; 125 pg\/mL; and at least one additional criterion for structural heart disease or diastolic dysfunction. All patients underwent transthoracic echocardiography, cardiopulmonary exercise testing, and pulse amplitude tonometry (EndoPAT\u2122). Patients were categorized in two groups based on their retrospectively calculated HFA-PEFF score. Serum concentrations of l-Arg, hArg, ADMA, SDMA, NT-proBNP, ET-1, MR-proADM, copeptin, and hsCRP were determined. Patients had a median age of 74 years, 47% were female, and median LVEF was 57%. Fifty-two patients (71%) had an HFA-PEFF score \u2265 5 (definitive HFpEF), and 21 patients (29%) a score of 3 to 4 (risk for HFpEF). Overall biomarker concentrations were 126 \u00b1 32 \u03bcmol\/L for l-Arg, 1.67 \u00b1 0.55 \u03bcmol\/L for hArg, 0.74 (0.60;0.85) \u03bcmol\/L for SDMA, and 0.61 \u00b1 0.10 \u03bcmol\/L for ADMA. The median reactive hyperaemia index (RHI) was 1.55 (1.38;1.87). SDMA correlated with NT-proBNP (r = 0.291; P = 0.013), ET-1 (r = 0.233; P = 0.047), and copeptin (r = 0.381; P = 0.001). ADMA correlated with ET-1 (r = 0.250; P = 0.033) and hsCRP (r = 0.303; P = 0.009). SDMA was associated with the left atrial volume index (\u03b2 = 0.332; P = 0.004), also after adjustment for age, sex, and comorbidities. Biomarkers were non-associated with the RHI. A principal component analysis revealed two contrary clusters of biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest an impaired NO metabolism as one possible key pathogenic determinant in at least a subgroup of patients with HFpEF. We argue for further evaluation of NO-based therapies. Upcoming studies should clarify whether subgroups of HFpEF patients can take more benefit from therapies that are targeting NO metabolism and pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.14116","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T07:01:45Z","timestamp":1660806105000},"page":"3961-3972","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Nitric Oxide Metabolites: Associations with Cardiovascular Biomarkers and Clinical Parameters in Patients with HFpEF"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8825-5929","authenticated-orcid":false,"given":"Karsten","family":"Piatek","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Virchow Klinikum , Augustenburger Platz 1, Berlin, 13353 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Feuerstein","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Virchow Klinikum , Augustenburger Platz 1, Berlin, 13353 ,","place":["Germany"]},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronika","family":"Zach","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Virchow Klinikum , Augustenburger Platz 1, Berlin, 13353 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Rozados da Conceicao","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Virchow Klinikum , Augustenburger Platz 1, Berlin, 13353 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amelie","family":"Beblo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Virchow Klinikum , Augustenburger Platz 1, Berlin, 13353 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgeny","family":"Belyavskiy","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Virchow Klinikum , Augustenburger Platz 1, Berlin, 13353 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Pieske-Kraigher","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Virchow Klinikum , Augustenburger Platz 1, Berlin, 13353 ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Krannich","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Research Center (ECRC), Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edzard","family":"Schwedhelm","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf , Hamburg ,","place":["Germany"]},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg\/Kiel\/L\u00fcbeck , Hamburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Hinz","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf , Hamburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burkert","family":"Pieske","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Virchow Klinikum , Augustenburger Platz 1, Berlin, 13353 ,","place":["Germany"]},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin , Berlin ,","place":["Germany"]},{"name":"Department of Cardiology, Deutsches Herzzentrum Berlin (DHZB) , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Edelmann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin, Campus Virchow Klinikum , Augustenburger Platz 1, Berlin, 13353 ,","place":["Germany"]},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,8,18]]},"reference":[{"key":"2026012114140590500_ehf214116-bib-0001","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1161\/CIRCULATIONAHA.111.080770","article-title":"Trends in patients hospitalized with heart failure and preserved left ventricular ejection fraction: prevalence, therapies, and outcomes","volume":"126","author":"Steinberg","year":"2012","journal-title":"Circulation"},{"key":"2026012114140590500_ehf214116-bib-0002","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) with the special contribution of the Heart Failure Association (HFA) of the ESC","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur Heart J"},{"key":"2026012114140590500_ehf214116-bib-0003","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jacc.2013.02.092","article-title":"A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation","volume":"62","author":"Paulus","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"2026012114140590500_ehf214116-bib-0004","doi-asserted-by":"crossref","first-page":"13725","DOI":"10.1016\/S0021-9258(17)36703-0","article-title":"Regulation of biosynthesis of nitric oxide","volume":"269","author":"Nathan","year":"1994","journal-title":"J Biol Chem"},{"key":"2026012114140590500_ehf214116-bib-0005","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/S0008-6363(99)00162-5","article-title":"Biological significance of endogenous methylarginines that inhibit nitric oxide synthases","volume":"43","author":"Leiper","year":"1999","journal-title":"Cardiovasc Res"},{"key":"2026012114140590500_ehf214116-bib-0006","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1007\/s00726-015-1993-2","article-title":"Homoarginine in the renal and cardiovascular systems","volume":"47","author":"Pilz","year":"2015","journal-title":"Amino Acids"},{"key":"2026012114140590500_ehf214116-bib-0007","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1161\/CIRCULATIONAHA.109.883777","article-title":"Uncoupled cardiac nitric oxide synthase mediates diastolic dysfunction","volume":"121","author":"Silberman","year":"2010","journal-title":"Circulation"},{"key":"2026012114140590500_ehf214116-bib-0008","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41586-019-1100-z","article-title":"Nitrosative stress drives heart failure with preserved ejection fraction","volume":"568","author":"Schiattarella","year":"2019","journal-title":"Nature"},{"key":"2026012114140590500_ehf214116-bib-0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mayocpiqo.2018.12.006","article-title":"Rethinking endothelial dysfunction as a crucial target in fighting heart failure","volume":"3","author":"Premer","year":"2019","journal-title":"Mayo Clin Proc Innov Qual Outcomes"},{"key":"2026012114140590500_ehf214116-bib-0010","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.cardfail.2015.09.003","article-title":"Vascular and microvascular endothelial function in heart failure with preserved ejection fraction","volume":"22","author":"Mar\u00e9chaux","year":"2016","journal-title":"J Card Fail"},{"key":"2026012114140590500_ehf214116-bib-0011","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1016\/j.jacc.2012.07.036","article-title":"Incremental prognostic significance of peripheral endothelial dysfunction in patients with heart failure with normal left ventricular ejection fraction","volume":"60","author":"Akiyama","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"2026012114140590500_ehf214116-bib-0012","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9123975","article-title":"Transport of L-arginine related cardiovascular risk markers","volume":"9","author":"Banjarnahor","year":"2020","journal-title":"J Clin Med"},{"key":"2026012114140590500_ehf214116-bib-0013","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1016\/j.jacc.2009.02.036","article-title":"Diminished global arginine bioavailability and increased arginine catabolism as metabolic profile of increased cardiovascular risk","volume":"53","author":"Tang","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"2026012114140590500_ehf214116-bib-0014","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0165811","article-title":"Asymmetric and symmetric dimethylarginine as risk markers for total mortality and cardiovascular outcomes: a systematic review and meta-analysis of prospective studies","volume":"11","author":"Schlesinger","year":"2016","journal-title":"PLoS ONE"},{"key":"2026012114140590500_ehf214116-bib-0015","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1161\/CIRCULATIONAHA.109.908988","article-title":"Homoarginine, cardiovascular risk, and mortality","volume":"122","author":"M\u00e4rz","year":"2010","journal-title":"Circulation"},{"key":"2026012114140590500_ehf214116-bib-0016","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1001\/jama.2018.14852","article-title":"Effect of inorganic nitrite vs placebo on exercise capacity among patients with heart failure with preserved ejection fraction: the INDIE-HFpEF randomized clinical trial","volume":"320","author":"Borlaug","year":"2018","journal-title":"JAMA"},{"key":"2026012114140590500_ehf214116-bib-0017","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1056\/NEJMoa1510774","article-title":"Isosorbide mononitrate in heart failure with preserved ejection fraction","volume":"373","author":"Redfield","year":"2015","journal-title":"N Engl J Med"},{"key":"2026012114140590500_ehf214116-bib-0018","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1001\/jama.2020.15922","article-title":"Effect of vericiguat vs placebo on quality of life in patients with heart failure and preserved ejection fraction: the VITALITY-HFpEF randomized clinical trial","volume":"324","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"key":"2026012114140590500_ehf214116-bib-0019","doi-asserted-by":"crossref","DOI":"10.3390\/toxins9030092","article-title":"Toxic dimethylarginines: asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA)","volume":"9","author":"Tain","year":"2017","journal-title":"Toxins (Basel)"},{"key":"2026012114140590500_ehf214116-bib-0020","first-page":"612","article-title":"Effect of L-arginine or L-citrulline oral supplementation on blood pressure and right ventricular function in heart failure patients with preserved ejection fraction","volume":"17","author":"Orozco-Guti\u00e9rrez","year":"2010","journal-title":"Cardiol J"},{"key":"2026012114140590500_ehf214116-bib-0021","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1159\/000501100","article-title":"Endothelin 1 is associated with heart failure hospitalization and long-term mortality in patients with heart failure with preserved ejection fraction and pulmonary hypertension","volume":"143","author":"Chowdhury","year":"2019","journal-title":"Cardiology"},{"key":"2026012114140590500_ehf214116-bib-0022","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1007\/s10741-020-09927-x","article-title":"Diagnostic and prognostic value of serum C-reactive protein in heart failure with preserved ejection fraction: a systematic review and meta-analysis","volume":"26","author":"Lakhani","year":"2020","journal-title":"Heart Fail Rev"},{"key":"2026012114140590500_ehf214116-bib-0023","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0053560","article-title":"Utility of biomarkers in the differential diagnosis of heart failure in older people: findings from the Heart Failure in Care Homes (HFinCH) diagnostic accuracy study","volume":"8","author":"Mason","year":"2013","journal-title":"PLoS ONE"},{"key":"2026012114140590500_ehf214116-bib-0024","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ijcard.2015.03.381","article-title":"Adaptive cardiovascular hormones in a spectrum of heart failure phenotypes","volume":"189","author":"Zabarovskaja","year":"2015","journal-title":"Int J Cardiol"},{"key":"2026012114140590500_ehf214116-bib-0025","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/332411a0","article-title":"A novel potent vasoconstrictor peptide produced by vascular endothelial cells","volume":"332","author":"Yanagisawa","year":"1988","journal-title":"Nature"},{"key":"2026012114140590500_ehf214116-bib-0026","doi-asserted-by":"crossref","first-page":"3718","DOI":"10.1093\/eurheartj\/ehz765","article-title":"Targeting the endothelin system: a step towards a precision medicine approach in heart failure with preserved ejection fraction?","volume":"40","author":"Omland","year":"2019","journal-title":"Eur Heart J"},{"key":"2026012114140590500_ehf214116-bib-0027","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1751-7133.2010.00177.x","article-title":"Copeptin: a biomarker of cardiovascular and renal function","volume":"16","author":"Morgenthaler","year":"2010","journal-title":"Congest Heart Fail"},{"key":"2026012114140590500_ehf214116-bib-0028","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1006\/bbrc.1994.1827","article-title":"Endothelial cells actively synthesize and secrete adrenomedullin","volume":"201","author":"Sugo","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"key":"2026012114140590500_ehf214116-bib-0029","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.jchromb.2006.11.052","article-title":"High-throughput liquid chromatographic-tandem mass spectrometric determination of arginine and dimethylated arginine derivatives in human and mouse plasma","volume":"851","author":"Schwedhelm","year":"2007","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"2026012114140590500_ehf214116-bib-0030","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1016\/j.jchromb.2011.06.016","article-title":"Stable isotope dilution assay for liquid chromatography-tandem mass spectrometric determination of L-homoarginine in human plasma","volume":"879","author":"Atzler","year":"2011","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"2026012114140590500_ehf214116-bib-0031","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1093\/eurheartj\/ehz641","article-title":"How to diagnose heart failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)","volume":"40","author":"Pieske","year":"2019","journal-title":"Eur Heart J"},{"key":"2026012114140590500_ehf214116-bib-0032","volume-title":"EndoPAT 2000 Device User Manual","author":"Itamar Medical Ltd","year":"2019"},{"key":"2026012114140590500_ehf214116-bib-0033","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1161\/CIR.0b013e3181e52e69","article-title":"Clinician's guide to cardiopulmonary exercise testing in adults: a scientific statement from the American Heart Association","volume":"122","author":"Balady","year":"2010","journal-title":"Circulation"},{"key":"2026012114140590500_ehf214116-bib-0034","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.006000","article-title":"Prognostic value of cardiopulmonary exercise testing in heart failure with reduced, midrange, and preserved ejection fraction","volume":"6","author":"Nadruz","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"2026012114140590500_ehf214116-bib-0035","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.cardfail.2021.02.005","article-title":"Generalizability of HFA-PEFF and H2FPEF diagnostic algorithms and associations with heart failure indices and proteomic biomarkers: insights from PROMIS-HFpEF","volume":"27","author":"Faxen","year":"2021","journal-title":"J Card Fail"},{"key":"2026012114140590500_ehf214116-bib-0036","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1002\/ehf2.13302","article-title":"Prognostic significance of the HFA-PEFF score in patients with heart failure with preserved ejection fraction","volume":"8","author":"Sotomi","year":"2021","journal-title":"ESC Heart Fail"},{"key":"2026012114140590500_ehf214116-bib-0037","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.cardfail.2014.09.004","article-title":"Associations of methylarginines and homoarginine with diastolic dysfunction and cardiovascular risk factors in patients with preserved left ventricular ejection fraction","volume":"20","author":"Pilz","year":"2014","journal-title":"J Card Fail"},{"key":"2026012114140590500_ehf214116-bib-0038","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2183\/pjab.82.17","article-title":"Endothelin and endothelial dysfunction","volume":"82","author":"Masaki","year":"2006","journal-title":"Proc Jpn Acad Ser B Phys Biol Sci"},{"key":"2026012114140590500_ehf214116-bib-0039","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/00005344-200307000-00020","article-title":"Effects of arginine vasopressin on growth of rat cardiac fibroblasts: role of V1 receptor","volume":"42","author":"Yang","year":"2003","journal-title":"J Cardiovasc Pharmacol"},{"key":"2026012114140590500_ehf214116-bib-0040","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.2215\/CJN.01720211","article-title":"Symmetric dimethylarginine as a proinflammatory agent in chronic kidney disease","volume":"6","author":"Schepers","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"2026012114140590500_ehf214116-bib-0041","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1093\/ndt\/gfn670","article-title":"Role of symmetric dimethylarginine in vascular damage by increasing ROS via store-operated calcium influx in monocytes","volume":"24","author":"Schepers","year":"2009","journal-title":"Nephrol Dial Transplant"},{"key":"2026012114140590500_ehf214116-bib-0042","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1002\/ehf2.12700","article-title":"Myeloperoxidase and related biomarkers are suggestive footprints of endothelial microvascular inflammation in HFpEF patients","volume":"7","author":"Hage","year":"2020","journal-title":"ESC Heart Fail"},{"key":"2026012114140590500_ehf214116-bib-0043","first-page":"577","article-title":"Endothelial function testing and cardiovascular disease: focus on peripheral arterial tonometry","volume":"10","author":"Bruno","year":"2014","journal-title":"Vasc Health Risk Manag"},{"key":"2026012114140590500_ehf214116-bib-0044","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1152\/japplphysiol.01285.2005","article-title":"Role of nitric oxide in the regulation of digital pulse volume amplitude in humans","volume":"101","author":"Nohria","year":"2006","journal-title":"J Appl Physiol (1985)"},{"key":"2026012114140590500_ehf214116-bib-0045","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1016\/j.jacc.2004.08.062","article-title":"Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia","volume":"44","author":"Bonetti","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"2026012114140590500_ehf214116-bib-0046","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1002\/ejhf.2171","article-title":"Targeting the nitrate-nitrite-nitric oxide pathway in heart failure with preserved ejection fraction: too soon to say no to nitric oxide?","volume":"23","author":"Wan","year":"2021","journal-title":"Eur J Heart Fail"},{"key":"2026012114140590500_ehf214116-bib-0047","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1002\/ejhf.2093","article-title":"Peripheral and pulmonary effects of inorganic nitrite during exercise in heart failure with preserved ejection fraction","volume":"23","author":"Reddy","year":"2021","journal-title":"Eur J Heart Fail"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ehf2.14116","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ehf2.14116","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/9\/6\/3961\/65347831\/eschf_9_6_3961.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/9\/6\/3961\/65347831\/eschf_9_6_3961.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T19:16:47Z","timestamp":1769023007000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/9\/6\/3961\/8322840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,18]]},"references-count":47,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,8,18]]},"published-print":{"date-parts":[[2022,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ehf2.14116","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,12]]},"published":{"date-parts":[[2022,8,18]]},"assertion":[{"value":"2022-04-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}