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We report on a 25-year-old man presenting with fever, rash, abdominal pain, diarrhoea and vomiting following prior asymptomatic COVID-19 infection. He developed refractory shock and type 1 respiratory insufficiency requiring mechanical ventilation. Diagnostic testing revealed significant inflammation, anemia, thrombocytopenia, acute kidney injury, hepatosplenomegaly, colitis, lymphadenopathy and myocarditis necessitating inotropy. Ventilatory, vasopressor and inotropic support was weaned following pulse corticosteroids and intravenous immunoglobulins. Heart failure therapy was started. Short-term follow-up shows resolution of inflammation and cardiac dysfunction.<\/jats:p>","DOI":"10.1002\/ehf2.14126","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T05:14:06Z","timestamp":1661922846000},"page":"4315-4324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["SARS-CoV-2-Related Multisystem Inflammatory Syndrome in Adult Complicated by Myocarditis and Cardiogenic Shock"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1885-7606","authenticated-orcid":false,"given":"M.A.J.","family":"De Smet","sequence":"first","affiliation":[{"name":"Department of Cardiology, Ghent University Hospital , Ghent ,","place":["Belgium"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Fierens","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Ghent University Hospital , Ghent 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