{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:42:27Z","timestamp":1786977747311,"version":"build-2736575974"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":1183,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Major Project of the Science and Technology Department in Sichuan province China","award":["2022YFS0112"],"award-info":[{"award-number":["2022YFS0112"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>During the coronavirus disease 2019 (COVID-19) pandemic, it has become difficult to provide centre-based cardiac rehabilitation for heart failure patients. Digital therapeutics is a novel concept proposed in recent years that refers to the use of evidence-based therapeutic interventions driven by high-quality software programs to treat, manage, or prevent a medical condition. However, little is known about the use of this technology in heart failure patients. This study aims to explore the safety and efficacy of digital therapeutics-based cardiac rehabilitation in heart failure patients and to provide new insights into a new cardiac rehabilitation model during the COVID-19 era. To identify technologies related to digital therapeutics, such as the use of medical applications, wearable devices, and the Internet, all relevant studies published on PubMed, EMBASE, Cochrane database, and China National Knowledge Internet were searched from the time the database was established until October 2021. The PEDro was used to assess the quality of included studies. We ultimately identified five studies, which included 1119 patients. The mean age was 66.37, the mean BMI was 25.9, and the NYHA classification ranged from I to III (I = 232, II = 157, III = 209). The mean 6-min walk distance was 397.7 m. The PEDro scores included in the study ranged from 4 to 8, with a mean of 5.8. Exercise training was performed in four studies, and psychological interventions were conducted in three studies. No death or serious adverse events were observed. Adherence was reported in three studies, and all exceeded 85%. The results of most studies showed that digital therapeutics-based cardiac rehabilitation significantly increases exercise capacity and quality of life in heart failure patients. Overall, although this study suggests that digital therapeutics-based cardiac rehabilitation may be a viable intervention for heart failure patients during the COVID-19 era, the efficacy of this new model in routine clinical practice needs to be further validated in a large clinical trial.<\/jats:p>","DOI":"10.1002\/ehf2.14145","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T21:39:45Z","timestamp":1662759585000},"page":"3751-3760","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Efficacy and Safety of Digital Therapeutics-Based Cardiac Rehabilitation in Heart Failure Patients: A Systematic Review"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7451-8035","authenticated-orcid":false,"given":"Xiu","family":"Zhang","sequence":"first","affiliation":[{"name":"Rehabilitation Medicine Center, West China Hospital, Sichuan University , Chengdu, Sichuan Province ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeruxin","family":"Luo","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine Center, West China Hospital, Sichuan University , Chengdu, Sichuan Province ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine Center, West China Hospital, Sichuan University , Chengdu, Sichuan Province ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine Center, West China Hospital, Sichuan University , Chengdu, Sichuan Province ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengming","family":"Yu","sequence":"additional","affiliation":[{"name":"Rehabilitation Medicine Center, West China Hospital, 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