{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T14:36:05Z","timestamp":1793975765084,"version":"4.8.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":1179,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Data on the association between periodontitis and preclinical cardiac alterations remain scarce. The aim of the current study is to determine if periodontitis is associated with morphological and functional cardiac changes measured by transthoracic echocardiography as well as different heart failure (HF) phenotypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants from the population-based Hamburg City Health Study [ClinicalTrial.gov (NCT03934957)], who underwent transthoracic echocardiography and periodontal screening were included. Periodontitis was classified according to Eke and Page (none\/mild, moderate, severe). The 2021 ESC HF guidelines were applied and HF was classified into HF with preserved ejection fraction (HFpEF, ejection fraction \u226550%), HF with mid-range and reduced ejection fraction [HF(m)rEF, ejection fraction &amp;lt;50%], and HF in general [HFpEF and HF(m)rEF]. Due to limited size, all subjects with LVEF &amp;lt;50% and symptoms or signs of HF were classified as HF with reduced and mildly reduced ejection fraction [HF(m)rEF].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Within 6209 participants with full periodontal examination, we identified an overlap of n = 167 participants with periodontitis and HF. Participants with severe periodontitis showed a higher burden of cardiovascular risk factors (men at advanced age, diabetes mellitus, hypertension) when compared with participants with none\/mild periodontitis. After adjustment for age, sex, body mass index, smoking, diabetes, hypertension, atrial fibrillation, and coronary artery disease, severe periodontitis was significantly associated with HF(m)rEF (odds ratio: 3.16; 95% CI: 1.21, 8.22; P = 0.019), although no association was found for HFpEF and HF in general.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The current study demonstrated that severe periodontitis was significantly associated with HF(m)rEF, although no relevant associations were found with HFpEF and HF in general as well as echocardiographic variables. The results implicate a potential target group, who need special attention from cooperating physicians and dentists. Future studies are warranted to verify whether systemic inflammation could be the link between the two diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ehf2.14150","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T01:21:40Z","timestamp":1663118500000},"page":"4189-4197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Association Between Periodontitis and Heart Failure in the General Population"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1307-5672","authenticated-orcid":false,"given":"Carolin","family":"Walther","sequence":"first","affiliation":[{"name":"Department of Periodontics, Preventive and Restorative Dentistry, University Medical Center Hamburg-Eppendorf , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6302-8671","authenticated-orcid":false,"given":"Jan-Per","family":"Wenzel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart and Vascular Center Hamburg, UKE Hamburg , Hamburg ,","place":["Germany"]},{"name":"Epidemiological Study Center, University Medical Center Hamburg-Eppendorf (UKE) , Hamburg ,","place":["Germany"]},{"name":"Population Health Research Department, University Heart and Vascular Center, UKE Hamburg , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renate B.","family":"Schnabel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart and Vascular Center Hamburg, UKE Hamburg , Hamburg ,","place":["Germany"]},{"name":"Population Health Research Department, University Heart and Vascular Center, UKE Hamburg , Hamburg ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK) Partner Site Hamburg\/Kiel\/Luebeck , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Heydecke","sequence":"additional","affiliation":[{"name":"Department of Prosthetic Dentistry, Center for Dental and Oral Medicine, University Medical Center Hamburg-Eppendorf , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udo","family":"Seedorf","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Preventive and Restorative Dentistry, University Medical Center Hamburg-Eppendorf , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Beikler","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Preventive and Restorative Dentistry, University Medical Center Hamburg-Eppendorf , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Borof","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Preventive and Restorative Dentistry, University Medical Center Hamburg-Eppendorf , Hamburg ,","place":["Germany"]},{"name":"Population Health Research Department, University Heart and Vascular Center, UKE Hamburg , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius","family":"Nikorowitsch","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart and Vascular Center Hamburg, UKE Hamburg , Hamburg ,","place":["Germany"]},{"name":"Epidemiological Study Center, University Medical Center Hamburg-Eppendorf (UKE) , Hamburg ,","place":["Germany"]},{"name":"Population Health Research Department, University Heart and Vascular Center, UKE Hamburg , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"Schrage","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart and Vascular Center Hamburg, UKE Hamburg , Hamburg ,","place":["Germany"]},{"name":"Population Health Research Department, University Heart and Vascular Center, UKE Hamburg , Hamburg ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK) Partner Site Hamburg\/Kiel\/Luebeck , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Blankenberg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart and Vascular Center Hamburg, UKE Hamburg , Hamburg ,","place":["Germany"]},{"name":"Population Health Research Department, University Heart and Vascular Center, UKE Hamburg , Hamburg ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK) Partner Site Hamburg\/Kiel\/Luebeck , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Twerenbold","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart and Vascular Center Hamburg, UKE Hamburg , Hamburg ,","place":["Germany"]},{"name":"Epidemiological Study Center, University Medical Center Hamburg-Eppendorf (UKE) , Hamburg ,","place":["Germany"]},{"name":"Population Health Research Department, University Heart and Vascular Center, UKE Hamburg , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Zeller","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart and Vascular Center Hamburg, UKE Hamburg , Hamburg ,","place":["Germany"]},{"name":"University Center of Cardiovascular Science, University Heart and Vascular Center , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Magnussen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart and Vascular Center Hamburg, UKE Hamburg , Hamburg ,","place":["Germany"]},{"name":"Population Health Research Department, University Heart and Vascular Center, UKE Hamburg , Hamburg ,","place":["Germany"]},{"name":"German Center for Cardiovascular Research (DZHK) Partner Site Hamburg\/Kiel\/Luebeck , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghazal","family":"Aarabi","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Preventive and Restorative Dentistry, University Medical Center Hamburg-Eppendorf , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,13]]},"reference":[{"key":"2026012114140013700_ehf214150-bib-0001","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1177\/0022034520908533","article-title":"Global, regional, and national levels and trends in burden of oral conditions from 1990 to 2017: A systematic analysis for the global burden of disease 2017 study","volume":"99","author":"GBD 2017 Oral Disorders Collaborators","year":"2020","journal-title":"J Dent Res"},{"key":"2026012114140013700_ehf214150-bib-0002","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/prd.12147","article-title":"Microbial colonization of the periodontal pocket and its significance for periodontal therapy","volume":"76","author":"Mombelli","year":"2018","journal-title":"Periodontol 2000"},{"key":"2026012114140013700_ehf214150-bib-0003","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/art.41572","article-title":"Associations of antibodies targeting periodontal pathogens with subclinical coronary, carotid, and peripheral arterial atherosclerosis in rheumatoid arthritis","volume":"73","author":"Giles","year":"2020","journal-title":"Arthritis Rheum"},{"key":"2026012114140013700_ehf214150-bib-0004","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/prd.12297","article-title":"The role of inflammation and genetics in periodontal disease","volume":"83","author":"Loos","year":"2020","journal-title":"Periodontol 2000"},{"key":"2026012114140013700_ehf214150-bib-0005","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur Heart J"},{"key":"2026012114140013700_ehf214150-bib-0006","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/ejhf.483","article-title":"Epidemiology of heart failure: The prevalence of heart failure and ventricular dysfunction in older adults over time. A systematic review","volume":"18","author":"van Riet","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"2026012114140013700_ehf214150-bib-0007","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","article-title":"2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: The task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)developed with the special contribution of the Heart Failure Association (HFA) of the ESC","volume":"37","author":"Ponikowski","year":"2016","journal-title":"Eur Heart J"},{"key":"2026012114140013700_ehf214150-bib-0008","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3390\/cells9010242","article-title":"Cellular and molecular differences between HFpEF and HFrEF: A step ahead in an improved pathological understanding","volume":"9","author":"Simmonds","year":"2020","journal-title":"Cell"},{"key":"2026012114140013700_ehf214150-bib-0009","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41569-019-0315-x","article-title":"Reappraising the role of inflammation in heart failure","volume":"17","author":"Adamo","year":"2020","journal-title":"Nat Rev Cardiol"},{"key":"2026012114140013700_ehf214150-bib-0010","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jacc.2013.02.092","article-title":"A novel paradigm for heart failure with preserved ejection fraction","volume":"62","author":"Paulus","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"2026012114140013700_ehf214150-bib-0011","doi-asserted-by":"crossref","DOI":"10.1038\/srep05171","article-title":"Periodontitis-activated monocytes\/macrophages cause aortic inflammation","volume":"4","author":"Miyajima","year":"2014","journal-title":"Sci Rep"},{"key":"2026012114140013700_ehf214150-bib-0012","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1111\/febs.15486","article-title":"Mechanisms of vascular damage by systemic dissemination of the oral pathogen Porphyromonas gingivalis","volume":"288","author":"Farrugia","year":"2021","journal-title":"FEBS J"},{"key":"2026012114140013700_ehf214150-bib-0013","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41368-020-00096-z","article-title":"Porphyromonas gingivalis disrupts vascular endothelial homeostasis in a TLR-NF-\u03baB axis dependent manner","volume":"12","author":"Xie","year":"2020","journal-title":"Int J Oral Sci"},{"key":"2026012114140013700_ehf214150-bib-0014","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1536\/ihj.19-010","article-title":"Increased heart failure prevalence in patients with a high antibody level against periodontal pathogen","volume":"60","author":"Aoyama","year":"2019","journal-title":"Int Heart J"},{"key":"2026012114140013700_ehf214150-bib-0015","doi-asserted-by":"crossref","first-page":"297","DOI":"10.14503\/THIJ-15-5200","article-title":"Periodontitis in chronic heart failure","volume":"43","author":"Fr\u00f6hlich","year":"2016","journal-title":"Tex Heart Inst J"},{"key":"2026012114140013700_ehf214150-bib-0016","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s10654-019-00577-4","article-title":"Rationale and Design of the Hamburg City Health Study","volume":"35","author":"Jagodzinski","year":"2020","journal-title":"Eur J Epidemiol"},{"key":"2026012114140013700_ehf214150-bib-0017","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jclinepi.2007.11.008","article-title":"The strengthening the reporting of observational studies in epidemiology (STROBE) statement: Guidelines for reporting observational studies","volume":"61","author":"von Elm","year":"2008","journal-title":"J Clin Epidemiol"},{"key":"2026012114140013700_ehf214150-bib-0018","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1902\/jop.2012.110664","article-title":"Update of the case definitions for population-based surveillance of periodontitis","volume":"83","author":"Eke","year":"2012","journal-title":"J Periodontol"},{"key":"2026012114140013700_ehf214150-bib-0019","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/jcpe.12392","article-title":"Standards for reporting chronic periodontitis prevalence and severity in epidemiologic studies: Proposed standards from the Joint EU\/USA Periodontal Epidemiology Working Group","volume":"42","author":"Holtfreter","year":"2015","journal-title":"J Clin Periodontol"},{"key":"2026012114140013700_ehf214150-bib-0020","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1002\/ehf2.13948","article-title":"Heart failure in the general population and impact of the 2021 European Society of Cardiology Heart Failure Guidelines","volume":"9","author":"Wenzel","year":"2022","journal-title":"ESC Heart Fail"},{"key":"2026012114140013700_ehf214150-bib-0021","volume-title":"Classifying educational programmes: manual for ISCED-97 implementation in OECD countries","author":"Organisation for Economic Co-operation and Development","year":"1999"},{"key":"2026012114140013700_ehf214150-bib-0022","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nrcardio.2016.25","article-title":"Epidemiology and aetiology of heart failure","volume":"13","author":"Ziaeian","year":"2016","journal-title":"Nat Rev Cardiol"},{"key":"2026012114140013700_ehf214150-bib-0023","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/j.amjcard.2015.02.024","article-title":"Meta-analysis of the relation of body mass index to all-cause and cardiovascular mortality and hospitalization in patients with chronic heart failure","volume":"115","author":"Sharma","year":"2015","journal-title":"Am J Cardiol"},{"key":"2026012114140013700_ehf214150-bib-0024","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1177\/2047487318806658","article-title":"Tobacco smoking and the risk of heart failure: A systematic review and meta-analysis of prospective studies","volume":"26","author":"Aune","year":"2020","journal-title":"Eur J Prev Cardiol"},{"key":"2026012114140013700_ehf214150-bib-0025","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1161\/CIRCRESAHA.118.311371","article-title":"Heart failure in type 2 diabetes mellitus","volume":"124","author":"Kenny","year":"2019","journal-title":"Circ Res"},{"key":"2026012114140013700_ehf214150-bib-0026","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.jchf.2019.03.005","article-title":"Heart failure and atrial fibrillation, like fire and fury","volume":"7","author":"Carlisle","year":"2019","journal-title":"JACC Heart Fail"},{"key":"2026012114140013700_ehf214150-bib-0027","first-page":"531","article-title":"Epidemiology and pathogenesis of heart failure with preserved ejection fraction","volume":"21","author":"Nair","year":"2020","journal-title":"RCM"},{"key":"2026012114140013700_ehf214150-bib-0028","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/jre.12634","article-title":"Periodontitis links to exacerbation of myocardial dysfunction in subjects with type 2 diabetes","volume":"54","author":"Wang","year":"2019","journal-title":"J Periodontal Res"},{"key":"2026012114140013700_ehf214150-bib-0029","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1161\/01.HYP.0000056525.17476.D7","article-title":"Association between periodontal disease and left ventricle mass in essential hypertension","volume":"41","author":"Angeli","year":"2003","journal-title":"Hypertension"},{"key":"2026012114140013700_ehf214150-bib-0030","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/ajh.2008.330","article-title":"Association of chronic periodontitis with left ventricular mass and central blood pressure in treated patients with essential hypertension","volume":"22","author":"Franek","year":"2009","journal-title":"Am J Hypertens"},{"key":"2026012114140013700_ehf214150-bib-0031","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1177\/2047487319886018","article-title":"Improved oral hygiene care is associated with decreased risk of occurrence for atrial fibrillation and heart failure: A nationwide population-based cohort study","volume":"27","author":"Chang","year":"2020","journal-title":"Eur J Prev Cardiol"},{"key":"2026012114140013700_ehf214150-bib-0032","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1007\/s00392-019-01430-0","article-title":"Non-cardiac comorbidities and mortality in patients with heart failure with reduced vs. preserved ejection fraction: A study using the Swedish heart failure registry","volume":"108","author":"Ergatoudes","year":"2019","journal-title":"Clin Res Cardiol"},{"key":"2026012114140013700_ehf214150-bib-0033","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2017.1332710","article-title":"Comorbidity of periodontal disease: Two sides of the same coin? An introduction for the clinician","volume":"9","author":"Holmstrup","year":"2017","journal-title":"J Oral Microbiol"},{"key":"2026012114140013700_ehf214150-bib-0034","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s10741-019-09881-3","article-title":"Role of endothelial dysfunction in heart failure","volume":"25","author":"Zuchi","year":"2020","journal-title":"Heart Fail Rev"},{"key":"2026012114140013700_ehf214150-bib-0035","doi-asserted-by":"crossref","first-page":"16609","DOI":"10.18632\/aging.103864","article-title":"Autoantibodies against M(5)-muscarinic and beta(1)-adrenergic receptors in periodontitis patients","volume":"12","author":"Scherbaum","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"2026012114140013700_ehf214150-bib-0036","doi-asserted-by":"crossref","DOI":"10.1161\/circ.143.suppl_1.MP34","article-title":"Abstract MP34: The association between periodontal disease and incident heart failure: The atherosclerosis risk in communities study","volume":"143","author":"Molinsky","year":"2021","journal-title":"Circulation"},{"key":"2026012114140013700_ehf214150-bib-0037","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1161\/CIRCRESAHA.115.302922","article-title":"Heart failure with preserved ejection fraction: Mechanisms, clinical features, and therapies","volume":"115","author":"Sharma","year":"2014","journal-title":"Circ Res"}],"container-title":["ESC Heart Failure"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ehf2.14150","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ehf2.14150","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/9\/6\/4189\/65347646\/eschf_9_6_4189.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/eschf\/article-pdf\/9\/6\/4189\/65347646\/eschf_9_6_4189.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T19:16:37Z","timestamp":1769022997000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/eschf\/article\/9\/6\/4189\/8322833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,13]]},"references-count":37,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,9,13]]},"published-print":{"date-parts":[[2022,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/ehf2.14150","relation":{},"ISSN":["2055-5822"],"issn-type":[{"value":"2055-5822","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,12]]},"published":{"date-parts":[[2022,9,13]]},"assertion":[{"value":"2022-03-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}